HPMC inonzi hydroxypropyl methylcellulose.
Chigadzirwa cheHPMC chinosarudza donje rakanyatsonaka secellulose sechinhu chisina kugadzirwa uye chinogadzirwa ne etherification chaiyo pasi pemamiriro e alkaline. Maitiro ese anopedzwa pasi pemamiriro e GMP uye kutariswa otomatiki, pasina zvinhu zvinoshanda zvakaita senhengo dzemhuka nemafuta.
Hunhu hweHPMC:
Chigadzirwa cheHPMC hachisi cheionic cellulose ether, chitarisiko chayo ihupfu chena, hachina hwema, hachinyungudike mumvura uye mune zvakawanda zvinonyungudutsa (senge dichloroethane) uye chikamu chakakodzera cheethanol/mvura, propyl alcohol/mvura, nezvimwewo. Mhinduro yemvura ine basa repamusoro, yakajeka uye inoshanda zvakatsiga. HPMC ine hunhu hwe thermal gel, mhinduro yemvura yechigadzirwa inopiswa kuti igadzire gel precipitation, uye yozonyungudika mushure mekutonhora, zvirevo zvakasiyana zvetembiricha yegel yechigadzirwa zvakasiyana. Kunyungudika kunochinja ne viscosity, viscosity yakaderera, kunyungudika kukuru, zvirevo zvakasiyana zveHPMC zvine musiyano muhunhu hwayo, HPMC mumvura haikanganisike nePH value. Saizi yezvikamu: 100 mesh pass rate yakakura kupfuura 100%. Kuwanda kwehuwandu: 0.25-0.70g/ (kazhinji inenge 0.5g/), dhiravhiti chaiyo 1.26-1.31. Tembiricha yekuchinja ruvara: 190-200℃, tembiricha ye carbonization: 280-300℃. Kusimba kwemvura: 42-56dyn/cm mu 2% yemvura. Nekuwedzera kwehuwandu hwemethoxyl, gel point yakaderera, mvura inonyunguduka yakawedzera, uye kushanda kwemvura kwakawedzerawo. HPMC ine hunhu hwekukora, kuisa munyu, dota shoma, PH yakasimba, kuchengetedza mvura, kugadzikana kwemativi, kugadzira firimu rakanaka uye kuramba zvakanyanya enzyme, kupararira uye kubatana.
Mashandisirwo eHPMC:
1. Kuputira mapiritsi: HPMC inoshandiswa sechishongo chepurasitiki mukugadzirwa kwakasimba, inogona kugadzira firimu rakasimba, rakatsetseka uye rakanaka, huwandu hwekushandiswa kwe 2%-8%. Mushure mekuputira, kugadzikana kwemushonga kuchiedza, kupisa uye hunyoro kunowedzerwa; Haina kunaka uye haina hwema, iri nyore kutora, uye HPMC pigment, sunscreen, mafuta ekuzora nezvimwe zvinhu zvinoenderana zvakanaka. Kuputira kwakajairika: mvura kana 30-80% ethanol yekunyungudutsa HPMC, ine 3-6% solution, ichiwedzera zvimwe zvinhu (zvakaita se: tembiricha yevhu -80, mafuta emushonga, PEG400, talc, nezvimwewo).
2. Chidzitiro chekuparadzanisa chepurasitiki chinonyungudika: pamusoro pemapiritsi nemagranules, chidzitiro cheHPMC chinotanga chashandiswa sechidzitiro chekuparadzanisa chepurasitiki, uye chozoputirwa nechikamu cheHPMCP chinonyungudika chepurasitiki. Firimu reHPMC rinogona kuvandudza kugadzikana kwechinhu chinonyungudika chepurasitiki chinonyungudika chiri mudura.
3. Kugadzirira kusunungurwa kwenguva refu: uchishandisa HPMC sechinhu chinokonzera maburi uye uchishandisa ethyl cellulose sezvinhu zvemapfupa, mapiritsi anoshanda kwenguva refu anogona kugadzirwa.
4. Chinhu chinokora uye chinonamira chinodzivirira checolloid uye madonhwe emaziso: HPMC yechinhu chinokora inowanzo shandiswa nehuwandu hwe0.45-1%.
5. Namira: HPMC sechikamu chekubatanidza che2%-5%, chinoshandiswa kuvandudza kugadzikana kwenamira ye hydrophobic, chikamu chinowanzo shandiswa che0.5-1.5%.
6. Mushonga wekunonoka, mushonga wekusunungura unodzorwa uye mushonga wekumisa. Mushonga wekumisa: muyero wemushonga wekumisa i0.5-1.5%.
7. Chikafu: HPMC sechinhu chinosimbisa kukora chinowedzerwa kune zvakasiyana-siyana zvezvinwiwa, zvigadzirwa zvemukaka, zvinonhuhwirira, chikafu chinovaka muviri, sechinhu chinosimbisa kukora, chinosunga, chinosanganisa, chinomisa kukora, chinosimbisa kukora, chinochengetedza mvura, chinobvisa kukora, nezvimwewo.
8. Inoshandiswa muzvizoro semaglues, emulsifiers, agents dzinogadzira mafirimu, nezvimwewo.
Nguva yekutumira: Ndira-14-2022