Imiterere n'imikorere ya HPMC

HPMC yitwa hydroxypropyl methylcellulose.

Ibicuruzwa bya HPMC bihitamo cellulose y’ipamba nziza cyane nk'ibikoresho fatizo kandi bikorwa hakoreshejwe uburyo bwihariye bwo gupima ubushyuhe mu gihe cy’ubushyuhe bwa alkaline. Igikorwa cyose kirangira mu gihe cy’ubushyuhe bwa GMP no kugenzura mu buryo bwikora, nta bintu bikora nk'ingingo z'inyamaswa n'amavuta.

Imiterere ya HPMC:

Umusaruro wa HPMC ni eteri idakoresha ioni ya cellulose, igaragara nk'ifu yera, nta mpumuro igira, irashonga mu mazi no mu bintu byinshi biyungurura ibinyabuzima (nk'ikinyabutabire cya dichloroethane) kandi ingana neza na ethanol/amazi, propyl alcohol/amazi, nibindi. Umuti w'amazi ufite imikorere yo hejuru, umucyo mwinshi kandi uhoraho. HPMC ifite imiterere ya gel y'ubushyuhe, umuti w'amazi y'umusaruro ushyuha kugira ngo ukore gel, hanyuma ugashonga nyuma yo gukonja, imiterere itandukanye y'ubushyuhe bwa gel y'umusaruro iratandukanye. Imiterere y'umusaruro ihinduka bitewe n'ubushyuhe, uko ubushyuhe bugabanuka, uko gushonga kwiyongera, imiterere itandukanye ya HPMC ifite itandukaniro runaka mu miterere yayo, HPMC mu mazi ntigira ingaruka ku gaciro ka PH. Ingano y'uduce: Igipimo cyo gusohoka kwa mesh 100 kiri hejuru ya 100%. Ubucucike bw'umubumbe: 0.25-0.70g/ (ubusanzwe hafi 0.5g/), uburemere bwihariye 1.26-1.31. Ubushyuhe bwo guhindagurika kw'ibara: 190-200℃, ubushyuhe bwa karubone: 280-300℃. Ubushyuhe bw'ubuso: 42-56dyn/cm mu gisubizo cy'amazi cya 2%. Uko ingano ya methoxyl yiyongeraga, urugero rwa gel rwaragabanutse, ubushobozi bwo gushonga bw'amazi bwariyongereye, kandi imikorere y'ubuso nayo yariyongereye. HPMC ifite imiterere yo gukomera, gushyiramo umunyu, ivu rike, PH idahindagurika, kubika amazi, kudahindagurika, gukora filime nziza no kurwanya cyane enzyme, gutandukana no guhuza.

Porogaramu za HPMC:

1. Gusiga ibinini: HPMC ikoreshwa nk'ibikoresho byo gusiga mu buryo bw'urumuri mu gutegura neza, ishobora gukora firime ikomeye, yoroshye kandi nziza, ikoreshwa ikaba 2%-8%. Nyuma yo gusiga, ubushobozi bwo gusiga urumuri, ubushyuhe n'ubushuhe buriyongera; Nta buryohe kandi nta mpumuro, byoroshye gufata, hamwe n'ibara rya HPMC, amavuta yo kwisiga izuba, amavuta n'ibindi bikoresho bihuye neza. Gusiga bisanzwe: amazi cyangwa ethanol 30-80% yo gushonga HPMC, hamwe n'umuti wa 3-6%, wongeramo ibintu by'inyongera (nk'ubushyuhe bw'ubutaka -80, amavuta ya castor, PEG400, talc, nibindi).

2. Agace ko gutwikira ibintu mu buryo bushongesha mu mubiri: hejuru y'ibinini n'uduce duto, agace ko gutwikira ka HPMC kabanza gukoreshwa nk'agace ko gutwikira ibintu mu buryo bushongesha mu mubiri, hanyuma gashyirwamo agace ko gutwikira ibintu mu buryo bushongesha mu mubiri ka HPMCP. Agace ko gutwikira ibintu mu buryo bushongesha mu mubiri gashobora kunoza uburyo bwo gutwikira ibintu mu buryo bushongesha mu mubiri mu gihe bibitswe.

3. Gutegura irekurwa ry’uturemangingo mu buryo burambye: hakoreshejwe HPMC nk'ikintu gitera imyenge kandi hifashishijwe ethyl cellulose nk'ibikoresho by'amagufwa, ibinini birekurwa by’uturemangingo mu buryo burambye bishobora gukorwa.

4. Ingufu zo gufunga n'uburinzi bwa koloyide n'ibitonyanga by'amaso: HPMC yo gufunga ikoreshwa cyane mu gufunga ni 0.45-1%.

5. Kole: HPMC nk'igipimo rusange cya 2%-5%, gikoreshwa mu kunoza uburyo kole idashobora guhindagurika mu mazi, igipimo gisanzwe cya 0.5-1.5%.

6. Ikoreshwa mu gutinda, ikoreshwa mu gusohora ibintu mu buryo bugenzurwa n'ikoreshwa mu guhagarika ibintu. Ikoreshwa mu guhagarika ibintu: igipimo gisanzwe cy'ikoreshwa mu guhagarika ibintu ni 0.5-1.5%.

7. Ibiribwa: HPMC nk'ikintu cyongera ubushyuhe cyongewe mu binyobwa bitandukanye, ibikomoka ku mata, ibirungo, ibiryo by'intungamubiri, nk'ikintu cyongera ubushyuhe, ikintu gifunga, ikintu gihindura ubushyuhe, ikintu gihagarika amazi, ikintu gikomeza ubushyuhe, nibindi.

8. Ikoreshwa mu kwisiga nk'imitako, ibinyabutabire, ibikoresho bikora filime, nibindi.