Njengamanje, izinto zokusetshenziswa ezivuthiwe zama-capsule ezitshalo ikakhulukazi i-hydroxypropyl methylcellulose (HPMC) kanye ne-pullulan, kanti isitashi se-hydroxypropyl naso sisetshenziswa njengezinto zokusetshenziswa.
Kusukela ekuqaleni kweminyaka yama-2010,I-HPMCiye yasetshenziswa embonini yokukhiqiza ama-capsule ezitshalo zaseShayina, futhi ngokusekelwe ekusebenzeni kwayo okuhle, ama-capsule angenalutho e-HPMC athathe indawo eqinile emakethe yama-capsule, ekhombisa ukwanda okukhulu kwesidingo eminyakeni eyishumi edlule.
Ngokusho kwedatha yemboni, ngo-2020, inani lokuthengisa lasekhaya lama-capsule aqinile angenalutho lizoba cishe ama-capsule ayizigidigidi ezingama-200 (izimboni zemithi nemikhiqizo yezempilo zihlangene), lapho inani lokuthengisa lama-capsule e-HPMC lizoba cishe ama-capsule ayizigidigidi eziyi-11.3 (kufaka phakathi ukuthunyelwa kwamanye amazwe), ukwanda ngo-4.2% ngaphezu kuka-2019. %, okulinganiselwa cishe ku-5.5%. Imboni engeyona eyemithi ibiza u-93.0% wokusetshenziswa kwama-capsule e-HPMC eShayina, kanti ukukhula kwemboni yemikhiqizo yezempilo kuqhubekisela phambili ukuthengiswa kwama-capsule e-HPMC.
Kusukela ngo-2020 kuya ku-2025, i-CAGR yama-capsule e-HPMC anama-gelling agents kulindeleke ukuthi ibe ngu-6.7%, okuphakeme kunezinga lokukhula elingu-3.8% lama-capsule e-gelatin. Ngaphezu kwalokho, isidingo sama-capsule e-HPMC embonini yemikhiqizo yezempilo yasekhaya siphakeme kunesembonini yemithi.I-HPMCAma-capsule angasiza kokubili ngezinselele zikadokotela futhi avumelane nezintandokazi zamasiko nezokudla zabathengi emhlabeni wonke. Nakuba isidingo samanje sama-capsule e-HPMC sisephansi kakhulu kunesama-capsule e-gelatin, izinga lokukhula kwesidingo liphakeme kunele-capsule ye-gelatin.
1) Ukwakheka kanye nenqubo ephumelelayo, ngaphandle kwe-ejenti ye-gelling; inokuncibilika okungcono, ukuziphatha okuhlala njalo kokuncibilika ezindaweni ezahlukene, okungathinteki yi-pH kanye namandla e-ionic, futhi kuhlangabezana nezidingo ze-pharmacopoeia zamazwe amakhulu nezifunda;
2) Ngokuqukethwe kwe-alkaline ebuthakathaka, thuthukisa ukutholakala kwe-bioavailability futhi uthuthukise ukwenziwa kahle kwefomu lomthamo;
3) Ukubukeka kuhle, futhi imibala ekhethiwe iyanda kakhulu.
I-capsule ethambile iyilungiselelo elakhiwe ngokuvala uwoyela noma ukumiswa okusekelwe ku-oyela egobolondweni le-capsule, futhi ukuma kwalo kuyindilinga, kufana nomnqumo, kufana nenhlanzi encane, kufana nokuwa, njll. Libonakala ngokuncibilikisa noma ukuxhuma izithako ezisebenzayo ku-oyela, eliqala ngokushesha ukusebenza kanye nokutholakala okuphezulu kwe-bioavailability kunokwenza isithako esifanayo esisebenzayo sibe amaphilisi, futhi lisetshenziswe kabanzi ekulungiseleleni imikhiqizo yezempilo nemithi. Namuhla, ama-capsule athambile anezici ezahlukene njenge-enteric-coated, chewable, osmotic pump, sustainable-release, kanye ne-soft suppositories asevele emakethe. I-capsule ethambile yakhiwe yizithasiselo ze-colloid nezengezo ezisizayo. Phakathi kwazo, ama-colloid afana ne-gelatin noma i-vegetable gum yizona zinto eziyinhloko, futhi ikhwalithi yawo ithinta ngqo ukusebenza kwama-capsule athambile. Isibonelo, ukuvuza kwe-capsule shell, ukunamathela, ukufuduka kwezinto, ukubola kancane, kanye nokuhlakazeka kwama-capsule athambile kwenzeka ngesikhathi sokugcina. Izinkinga ezifana nokungalandeli imithetho zihlobene nakho.
Njengamanje, izinto eziningi ze-capsule zama-capsule athambile emithi ezweni lakithi ziyi-gelatin yezilwane, kodwa ngokuthuthukiswa okujulile nokusetshenziswa kwama-capsule athambile e-gelatin, ukushiyeka kwawo kanye nokushiyeka kwawo kuye kwabonakala kakhulu, njengemithombo eyinkimbinkimbi yezinto zokusetshenziswa, kanye nokusabela okulula kokuxhumanisa nama-aldehyde compounds Izinkinga zekhwalithi ezifana nesikhathi esifushane sokugcina kanye "nemfucuza emithathu" ekhiqizwa enkambisweni yokucwenga i-gelatin inomthelela omkhulu ekuvikelweni kwemvelo. Ngaphezu kwalokho, kukhona nenkinga yokuqina ebusika, okunomthelela omubi ekhwalithini yokulungiselela. Futhi ama-capsule athambile e-gum yemifino anomthelela omncane emvelweni ezungezile. Ngokuqubuka kwezifo ezithathelwanayo ezivela ezilwaneni emhlabeni wonke, umphakathi wamazwe omhlaba ukhathazeka kakhulu ngokuphepha kwemikhiqizo yezilwane. Uma kuqhathaniswa nama-capsule e-gelatin yezilwane, ama-capsule ezitshalo anezinzuzo ezivelele maqondana nokusebenza, ukuphepha, ukuzinza, kanye nokuvikelwa kwemvelo.
Engezai-hydroxypropyl methylcelluloseukunisela nokuhlakaza ukuze kutholakale isisombululo A; engeza i-gelling agent, i-coagulant, i-plasticizer, i-opacifier kanye ne-colorant emanzini bese uhlakaza ukuze kutholakale isisombululo B; hlanganisa izixazululo A kanye no-B, bese ushisa kufika ku-90 ~ 95°C, uvuselele bese ugcina kufudumele amahora angu-0.5 ~ 2, uphole kufika ku-55 ~ 70°C, gcina kufudumele bese umela ukuhlanzwa ukuze kutholakale iglu;
Indlela yokuthola uketshezi lweglue ngokushesha, inqubo evamile ukushisa kancane eketheni lokusabela isikhathi eside,
Abanye abakhiqizi badlula ngokushesha emshinini wokugaya i-colloid ngeglue yamakhemikhali
Isikhathi sokuthunyelwe: Ephreli-25-2024