I kēia manawa, ʻo nā mea maka oʻo o nā capsules mea kanu he hydroxypropyl methylcellulose (HPMC) a me ka pullulan, a hoʻohana ʻia hoʻi ka hydroxypropyl starch ma ke ʻano he mea maka.
Mai ka hoʻomaka ʻana o nā makahiki 2010,HPMCua hoʻopili ʻia ma ka ʻoihana hana capsule mea kanu Kina, a ma muli o kāna hana maikaʻi, ua noho paʻa nā capsules hakahaka HPMC i kahi ma ka mākeke capsule, e hōʻike ana i ka koi ikaika i ka piʻi ʻana o nā makahiki he ʻumi i hala.
Wahi a ka ʻikepili ʻoihana, i ka makahiki 2020, ʻo ka nui o ke kūʻai kūloko o nā capsules paʻakikī hakahaka e pili ana i 200 biliona capsules (ʻo nā ʻoihana lāʻau lapaʻau a me nā huahana olakino i hui pū ʻia), ʻo ia hoʻi ka nui o ke kūʻai aku o nā capsules HPMC e pili ana i 11.3 biliona capsules (me nā mea i hoʻokuʻu ʻia aku), he piʻi ʻana o 4.2% ma luna o 2019.%, e helu ana ma kahi o 5.5%. ʻO ka ʻoihana ʻaʻole lāʻau lapaʻau e helu ana no 93.0% o ka hoʻohana ʻana o nā capsules HPMC ma Kina, a ʻo ka ulu ʻana o ka ʻoihana huahana mālama ola e hoʻokele i ke kūʻai aku ʻana o nā capsules HPMC.
Mai 2020 a i 2025, ua manaʻo ʻia ka CAGR o nā capsules HPMC me nā mea hana gelling he 6.7%, ʻoi aku ka kiʻekiʻe ma mua o ka ulu ʻana o 3.8% no nā capsules gelatin. Eia kekahi, ʻoi aku ke kiʻekiʻe o ke koi no nā capsules HPMC i ka ʻoihana huahana mālama ola kino kūloko ma mua o ka ʻoihana lāʻau lapaʻau.HPMChiki i nā capsules ke kōkua i nā pilikia lapaʻau a hoʻokipa i nā makemake moʻomeheu a me nā meaʻai o nā mea kūʻai aku a puni ka honua. ʻOiai ʻoi aku ka haʻahaʻa o ke koi o kēia manawa no nā capsules HPMC ma mua o nā capsules gelatin, ʻoi aku ka kiʻekiʻe o ka ulu ʻana o ke koi ma mua o nā capsules gelatin.
1) Hoʻokumu a me ke kaʻina hana holomua, me ka ʻole o ka mea hana gelling; ʻoi aku ka maikaʻi o ka solubility, kūlike ka hana hoʻoheheʻe ʻana i nā ʻano media like ʻole, ʻaʻole i hoʻopilikia ʻia e ka pH a me ka ikaika ionic, a hoʻokō i nā koi pharmacopoeia o nā ʻāina nui a me nā ʻāina;
2) No ka ʻike alkaline nāwaliwali, hoʻomaikaʻi i ka bioavailability a hoʻomaikaʻi i ka hoʻonui ʻana i ke ʻano dosage;
3) He nani ke ʻano, a ʻoi aku ka nui o nā koho kala.
ʻO ke kāpule palupalu kahi hoʻomākaukau i hana ʻia ma ke sila ʻana i ka ʻaila a i ʻole ka hoʻokuʻu ʻana i ka ʻaila i loko o kahi pūpū kāpule, a he poepoe kona ʻano, ʻano ʻoliva, ʻano iʻa liʻiliʻi, ʻano kulu, a pēlā aku. Hōʻike ʻia ia ma ka hoʻoheheʻe ʻana a i ʻole ke kau ʻana i nā mea hana i loko o ka ʻaila, nona ka wikiwiki o ka hana a me ka bioavailability kiʻekiʻe ma mua o ka hana ʻana i ka mea hana like i loko o nā papa, a ua hoʻohana nui ʻia i ka hoʻomākaukau ʻana i nā huahana mālama ola kino a me nā lāʻau lapaʻau. I kēia mau lā, aia nā kāpule palupalu me nā ʻano like ʻole e like me ka uhi ʻia enteric, chewable, osmotic pump, sustained-release, a me nā suppositories palupalu ma ka mākeke. Hana ʻia ka pūpū kāpule palupalu me nā mea hoʻohui colloid a me nā mea kōkua. I waena o lākou, ʻo nā colloids e like me ka gelatin a i ʻole ka gum mea kanu nā mea nui, a pili pono ko lākou maikaʻi i ka hana o nā kāpule palupalu. No ka laʻana, ʻo ka leakage o ka pūpū kāpule, ka hoʻopili ʻana, ka neʻe ʻana o nā mea, ka lohi o ka disintegration, a me ka hoʻoheheʻe ʻana o nā kāpule palupalu i ka wā o ka mālama ʻana. Pili nā pilikia e like me ka hoʻokō ʻole.
I kēia manawa, ʻo ka hapa nui o nā mea capsule o nā capsules palupalu lāʻau lapaʻau ma koʻu ʻāina he gelatin holoholona, akā me ka hoʻomohala hohonu a me ka hoʻohana ʻana i nā capsules palupalu gelatin, ua ʻike nui ʻia kona mau hemahema a me nā hemahema, e like me nā kumu paʻakikī o nā mea maka, a me nā hopena maʻalahi o ka hoʻopili ʻana me nā hui aldehyde. ʻO nā pilikia maikaʻi e like me ka wā mālama pōkole a me nā "ʻōpala ʻekolu" i hana ʻia i ke kaʻina hana hoʻomaʻemaʻe gelatin he hopena nui aʻe i ka palekana o ke kaiapuni. Eia kekahi, aia kekahi pilikia o ka paʻakikī i ka hoʻoilo, kahi i loaʻa ai ka hopena maikaʻi ʻole i ka maikaʻi o ka hoʻomākaukau ʻana. A ʻoi aku ka liʻiliʻi o ka hopena o nā capsules palupalu gum mea kanu i ke kaiapuni a puni. Me nā maʻi lele o nā holoholona ma ka honua holoʻokoʻa, ke hopohopo nei ke kaiāulu honua e pili ana i ka palekana o nā huahana holoholona. Ke hoʻohālikelike ʻia me nā capsules gelatin holoholona, loaʻa i nā capsules mea kanu nā pono koʻikoʻi ma ke ʻano o ka hoʻohana ʻana, ka palekana, ke kūpaʻa, a me ka palekana o ke kaiapuni.
Hoʻohuihydroxypropyl methylcellulosei ka wai a hoʻopuehu e loaʻa ai ka hopena A; e hoʻohui i ka mea hana gelling, coagulant, plasticizer, opacifier a me ka colorant i ka wai a hoʻopuehu e loaʻa ai ka hopena B; e hoʻohui i nā hopena A a me B, a hoʻomehana a hiki i 90 ~ 95°C, e hoʻoulu a mālama i ka mahana no 0.5~2h, e hoʻomaʻalili i lalo i 55~70°C, e mālama i ka mahana a kū no ka defoaming e loaʻa ai ke kāpili;
Pehea e loaʻa koke ai ka wai lī, ʻo ke kaʻina hana maʻamau ka hoʻomehana mālie ʻana i loko o kahi ipu hoʻoheheʻe no ka manawa lōʻihi,
Hele koke kekahi mau mea hana ma o ka wili colloid ma o ke kāpili kemika
Ka manawa hoʻouna: ʻApelila-25-2024