Kuri ubu, ibikoresho fatizo by’ibimera bikuze cyane cyane hifashishijwe hydroxypropyl methylcellulose (HPMC) na pullulan, naho hydroxypropyl starch nayo ikoreshwa nk’ibikoresho fatizo.
Kuva mu ntangiriro z'imyaka ya 2010,HPMCyakoreshejwe mu nganda zikora capsule z’inganda zo mu Bushinwa, kandi hashingiwe ku mikorere yayo myiza, capsule zidafite aho zihuriye na HPMC zafashe umwanya ukomeye ku isoko rya capsule, zigaragaza ko abaguzi benshi biyongereye mu myaka icumi ishize.
Dukurikije amakuru y’inganda, mu 2020, ingano y’ibicuruzwa by’ubudozi bw’imbere mu gihugu bizaba miliyari 200 z’ibicuruzwa by’imiti n’ibicuruzwa by’ubuzima bishyizwe hamwe, aho ingano y’ibicuruzwa by’ubudozi bw’imiti ya HPMC izaba miliyari 11.3 z’ibicuruzwa by’imiti (harimo n’ibyoherezwa mu mahanga), ubwiyongere bwa 4.2% ugereranyije n’umwaka wa 2019, bungana na 5.5%. Inganda zitari iz’imiti zigize 93.0% by’ikoreshwa rya HPMC mu Bushinwa, kandi iterambere ry’inganda zikora ibijyanye n’ubuvuzi rituma HPMC igurishwa.
Kuva mu 2020 kugeza 2025, igipimo cya CAGR cya capsules za HPMC zifite ibikoresho bya gelling biteganijwe kuba 6.7%, kirenze igipimo cy’ubwiyongere bwa 3.8% bya capsules za gelatin. Byongeye kandi, icyifuzo cya capsules za HPMC mu nganda zikora ibikoresho by’ubuvuzi mu gihugu kiri hejuru kurusha icyo mu nganda zikora imiti.HPMCIbinini bya capsule bishobora gufasha mu bibazo byo kwa muganga no kwakira ibyo abaguzi bakunda mu muco no mu mirire yabo hirya no hino ku isi. Nubwo ubusanzwe ibinini bya capsule za HPMC bikiri hasi cyane ugereranyije n’ibinini bya gelatin, igipimo cy’ubwiyongere bw’ibinini bya gelatin kiri hejuru ugereranyije n’ibinini bya gelatin.
1) Uburyo bwo gukora no gutunganya ibintu, nta kintu kiyitera gushonga; ifite ubushobozi bwo gushonga neza, imyitwarire ihoraho yo gushonga mu buryo butandukanye, idahungabanyijwe na pH na ionic strength, kandi ihuye n'ibisabwa na pharmacopoeia mu bihugu bikomeye n'uturere;
2) Ku bijyanye n'ingano y'ibinure ifite alkaline nkeya, ongera ubushobozi bwo kuboneka no kunoza uburyo bwo gukoresha ingano y'ibinure;
3) Isura ni nziza, kandi amabara menshi ni menshi.
Kapsule yoroshye ni umuti ukorwa no gufunga amavuta cyangwa amavuta mu gishishwa cya kapsule, kandi imiterere yayo ni uruziga, isa n'umuzenguruko, isa n'ifi nto, isa n'igitonyanga, nibindi. Irangwa no gushonga cyangwa gushyira ibintu bikora mu mavuta, ifite imbaraga zo gutangira gukora vuba kandi ikaba ifite ubuzima bwinshi kurusha gukora ikintu kimwe gikora mu binini, kandi yakoreshejwe cyane mu gutegura imiti n'imiti. Muri iki gihe, kapsule zoroshye zifite imiterere itandukanye nka enteric-coated, chewing, osmotic pump, suppositories zoroshye zisanzwe ziri ku isoko. Kapsule yoroshye igizwe n'inyongera za colloid n'izindi. Muri zo, kapsule zoroshye nka gelatin cyangwa vegetable gum ni byo bigize ingenzi, kandi ubwiza bwazo bugira ingaruka zitaziguye ku mikorere ya kapsule zoroshye. Urugero, gushonga kwa kapsule, gufatana, kwimuka kw'ibintu, gushonga buhoro buhoro, no gushonga kwa kapsule zoroshye bibaho mu gihe cyo kubika. Ibibazo nko kutubahiriza amategeko bifitanye isano nabyo.
Muri iki gihe, ibikoresho byinshi bya capsule bya capsule zoroshye zo mu miti mu gihugu cyanjye ni gelatin y'amatungo, ariko bitewe n'iterambere ryimbitse ry'udupira tworoshye twa gelatin, inenge n'intege nke byayo byarushijeho kugaragara, nko kubona ibikoresho by'ibanze bigoye, no guhuza byoroshye n'ibinyabutabire bya aldehyde Ibibazo by'ubwiza nko kubika igihe gito n'"imyanda itatu" ikorwa mu gutunganya gelatin bigira ingaruka zikomeye ku kurengera ibidukikije. Byongeye kandi, hari n'ikibazo cyo gukomera mu gihe cy'itumba, bigira ingaruka mbi ku bwiza bw'itegurwa. Kandi udupira tworoshye twa gum y'imboga bigira ingaruka nke ku bidukikije. Hamwe n'icyorezo cy'indwara zandura zikomoka ku matungo hirya no hino ku isi, umuryango mpuzamahanga ukomeje guhangayikishwa n'umutekano w'ibikomoka ku matungo. Ugereranyije na capsule za gelatin y'amatungo, udupira tw'ibimera dufite inyungu zidasanzwe mu bijyanye no gukoresha, umutekano, ituze, no kurengera ibidukikije.
Ongerahohydroxypropyl methylcellulosekuvomera no gukwirakwiza kugira ngo ubone umuti A; ongeramo icyuma gitera gushonga, coagulant, plasticizer, opacifer n'umuti utera ibara mu mazi hanyuma uvange kugira ngo ubone umuti B; vanga umuti A na B, hanyuma ushyushye kugeza kuri 90 ~ 95°C, uvange kandi ubishyire mu bushyuhe amasaha 0.5 ~ 2, ukonje kugeza kuri 55 ~ 70°C, ubishyire mu bushyuhe hanyuma ubihagarike kugira ngo ubikuremo kole;
Uburyo bwo kubona kole vuba, igikorwa rusange ni ugushyushya buhoro buhoro mu isafuriya ikoresha uburyo bwo kuyishyushya igihe kirekire,
Bamwe mu bakora urusyo rwa colloid banyura vuba muri kole y'ubutabire
Igihe cyo kohereza: 25 Mata 2024