Parizvino, zvinhu zvakakura zvemacapsule emiti zvinonyanya kuve hydroxypropyl methylcellulose (HPMC) uye pullulan, uye hydroxypropyl starch inoshandiswawo sezvinhu zvisina kubikwa.
Kubva pakutanga kwema2010,HPMCYakashandiswa muindasitiri yekugadzira makapisi ezvirimwa zvemuChina, uye zvichibva pakushanda kwayo kwakanaka, makapisi eHPMC asina chinhu akatorwa zvakanyanya mumusika wemakapupisi, zvichiratidza kudiwa kwakawanda mumakore gumi apfuura.
Zvichienderana nedata reindasitiri, muna 2020, huwandu hwekutengesa hwemacapsules akaomarara emuno huchava macapsules angangoita mabhiriyoni mazana maviri (makambani emishonga nezvigadzirwa zvehutano zvakabatanidzwa), ayo huwandu hwekutengesa hwemacapsules eHPMC huchava macapsules angangoita mabhiriyoni gumi nerimwe nehafu (kusanganisira kunze kwenyika), kuwedzera kwe4.2% kupfuura 2019. %, zvichiita kuti ive neinenge 5.5%. Indasitiri isiri yemishonga inoita 93.0% yekushandiswa kwemacapsules eHPMC muChina, uye kukura kweindasitiri yezvigadzirwa zvehutano ndiko kunotungamira kutengeswa kwemacapsules eHPMC.
Kubva muna 2020 kusvika 2025, CAGR yemacapsules eHPMC ane ma gelling agents inotarisirwa kuva 6.7%, iyo iri pamusoro pekukura kwe3.8% yemacapsules egelatin. Uyezve, kudiwa kwemacapsules eHPMC muindasitiri yezvigadzirwa zvehutano hwemumba kwakakwira kupfuura kuri muindasitiri yemishonga.HPMCMakapisi anogona kubatsira nematambudziko ekurapwa nechiremba uye kugadzirisa zvinodiwa netsika nekudya nevatengi pasi rese. Kunyangwe kudiwa kwemakapupisi eHPMC kuri kushoma pane kwemakapisi egelatin, kuwedzera kwekudiwa kwacho kwakakwira kupfuura kwemakapisi egelatin.
1) Kugadzirwa kwemvura nekugadzirwa kwayo, isina chinhu chinobatsira pakunyunguduka kwemvura; ine kunyunguduka kuri nani, ine maitiro ekunyunguduka kwakafanana munzvimbo dzakasiyana, isingakanganiswi ne pH uye simba re ionic, uye inosangana nezvinodiwa zve pharmacopoeia zvenyika huru nenzvimbo;
2) Kana paine alkaline shoma, wedzera kuwanikwa kwemvura mumuviri uye wedzera kugona kwekushandisa mushonga;
3) Chitarisiko chacho chakanaka, uye sarudzo dzemavara dzawanda.
Kapusule yakapfava mushonga unogadzirwa nekuvhara mafuta kana mafuta muganda rekapusule, uye chimiro chayo chakaita denderedzwa, chakaita semuorivhi, chakaita sehove diki, chakaita sedonhwe, nezvimwewo. Inoratidzwa nekunyungudutsa kana kumisa zvinhu zvinoshanda mumafuta, izvo zvinokurumidza kushanda uye zvinowanikwa zvakanyanya kupfuura kugadzira chinhu chimwe chete chinoshanda mumapiritsi, uye zvave zvichishandiswa zvakanyanya mukugadzira zvigadzirwa zvehutano nemishonga. Mazuva ano, makapusule akapfava ane hunhu hwakasiyana senge enteric-coated, chewable, osmotic pump, sustained-release, uye soft suppositories atove kutengeswa. Kapusule yakapfava inoumbwa necolloid uye assistant additives. Pakati pawo, macolloid akadai segelatin kana vegetable gum ndiwo zvikamu zvikuru, uye hunhu hwavo hunokanganisa zvakananga mashandiro emakapusule akapfava. Semuenzaniso, kudonha kweganda rekapusule, kunamira, kufamba kwezvinhu, kuputsika zvishoma nezvishoma, uye kunyungudika kwemakapusule akapfava kunoitika panguva yekuchengetedza Matambudziko akadai sekusatevedzera mitemo ane chekuita nazvo.
Parizvino, zvinhu zvakawanda zvemacapsule emishonga yakapfava mumacapsules munyika yangu igelatin yemhuka, asi nekugadzirwa kwakadzama uye kushandiswa kwemacapsules akapfava egelatin, zvikanganiso zvayo nekushomeka kwave kuonekwa zvakanyanya, senge manyuko akaomarara ezvigadzirwa, uye nyore nyore kubatanidza macompounds ealdehyde Matambudziko emhando dzakadai senguva pfupi yekuchengetedza uye "marara matatu" anogadzirwa mukugadzirisa gelatin ane simba guru pakuchengetedzwa kwezvakatipoteredza. Pamusoro pezvo, kunewo dambudziko rekuomarara munguva yechando, izvo zvine simba rakaipa pamhando yekugadzirira. Uye macapsules akapfava emagum emuriwo haana simba rakawanda panharaunda yakapoteredza. Nekubuda kwezvirwere zvinotapukira zvinobva kumhuka pasi rese, nharaunda yepasi rose iri kunetseka zvakanyanya nezvekuchengetedzwa kwezvigadzirwa zvemhuka. Zvichienzaniswa nemacapsules egelatin emhuka, macapsules emiti ane mabhenefiti makuru maererano nekushanda, kuchengetedzeka, kugadzikana, uye kuchengetedzwa kwezvakatipoteredza.
Wedzerahydroxypropyl methylcellulosekudiridza wobva waparadzira kuti uwane mhinduro A; wedzera gelling agent, coagulant, plasticizer, opacifier uye colorant mumvura wobva waparadzira kuti uwane mhinduro B; sanganisa mhinduro A naB, wodziisa kusvika 90 ~ 95°C, kurunga wobva wadziisa kwe0.5 ~ 2awa, tonhodza kusvika 55 ~ 70°C, ramba uchidziisa womira kuti ubvise glue kuti uwane guruu;
Maitiro ekukurumidza kuwana mvura yeglue, maitiro ese ndeekupisa zvishoma nezvishoma mukettle ye reaction kwenguva yakareba,
Vamwe vagadziri vanokurumidza kupfuura nemuchina wekugadzira colloid kuburikidza neglue remakemikari
Nguva yekutumira: Kubvumbi-25-2024