Okwangoku, izinto ezivuthiweyo ze-capsules zezityalo ikakhulu yi-hydroxypropyl methylcellulose (HPMC) kunye ne-pullulan, kwaye i-hydroxypropyl starch ikwasetyenziswa njengezinto eziluhlaza.
Ukususela ekuqaleni kweminyaka yoo-2010,I-HPMCIsetyenziswe kwishishini lokuvelisa iikhaphu zezityalo zaseTshayina, kwaye ngokusekelwe ekusebenzeni kwayo okuhle, iikhaphu ezingenanto zeHPMC zithathe indawo eqinileyo kwimarike yeekhaphu, zibonisa ukwanda okukhulu kwemfuno kwiminyaka elishumi edlulileyo.
Ngokwedatha yeshishini, ngo-2020, umthamo wentengiso yasekhaya yeekhaphu eziqinileyo ezingenanto uza kuba malunga neekhaphu ezingama-200 eebhiliyoni (ishishini lemveliso yamayeza kunye nezempilo zidibene), apho umthamo wentengiso yeekhaphu zeHPMC uza kuba malunga neekhaphu ezili-11.3 eebhiliyoni (kuquka nokuthunyelwa kwamanye amazwe), ukunyuka kwe-4.2% ngaphezulu kowama-2019. %, oku kuthetha malunga ne-5.5%. Ishishini elingengolamayeza libandakanya i-93.0% yokusetyenziswa kweekhaphu zeHPMC eTshayina, kwaye ukukhula kweshishini lemveliso yezempilo kuqhuba ukuthengiswa kweekhaphu zeHPMC.
Ukususela ngo-2020 ukuya ku-2025, i-CAGR yeekhaphu ze-HPMC ezinee-gelling agents kulindeleke ukuba ibe yi-6.7%, nto leyo ephezulu kunezinga lokukhula le-3.8% kwiikhaphu ze-gelatin. Ngaphezu koko, imfuno yeekhaphu ze-HPMC kwishishini leemveliso zempilo zasekhaya iphezulu kuneyo kwishishini lamayeza.I-HPMCIikhaphu zinokunceda kwimingeni kagqirha kwaye zilungelelanise iinkcubeko kunye nokutya okuthandwayo ngabathengi kwihlabathi liphela. Nangona imfuno yangoku yeekhaphu zeHPMC isephantsi kakhulu kuneyeekhaphu zegelatin, izinga lokukhula kwemfuno liphezulu kuneleekhaphu zegelatin.
1) Ukwenziwa kunye nenkqubo yophuhliso, ngaphandle kwe-gelling agent; inokunyibilika okungcono, ukuziphatha kokunyibilika okuhlala kusenzeka kwiindawo ezahlukeneyo, akuchaphazeleki yi-pH kunye namandla e-ionic, kwaye ihlangabezana neemfuno ze-pharmacopoeia zamazwe amakhulu kunye nemimandla;
2) Ukuba kukho i-alkaline encinci, phucula ukufumaneka kwayo kwaye uphucule ukwenziwa kakuhle kwedosi;
3) Imbonakalo intle, kwaye ukhetho lwemibala luninzi.
I-capsule ethambileyo yilungiselelo elenziwe ngokutywina ioyile okanye i-oyile exutywe neoyile kwiqokobhe le-capsule, kwaye imilo yalo ingqukuva, imile okwe-olive, imile okwentlanzi encinci, imile okwe-drop, njl. Ibonakaliswa ngokunyibilikisa okanye ukuxhoma izithako ezisebenzayo kwioyile, eqala ukusebenza ngokukhawuleza kwaye ifumaneka kakhulu kwi-bioavailability kunokwenza isithako esifanayo esisebenzayo kwiipilisi, kwaye isetyenziswa kakhulu ekulungiseleleni iimveliso zonyango kunye namayeza. Kule mihla, ii-capsules ezithambileyo ezineempawu ezahlukeneyo ezifana ne-enteric-coated, chewable, osmotic pump, sustainable-release, kunye ne-soft suppositories sele zithengiswa. Iqokobhe le-capsule ethambileyo lenziwe nge-colloid kunye nezongezo ezincedisayo. Phakathi kwazo, ii-colloids ezifana ne-gelatin okanye i-vegetable gum zezona zinto ziphambili, kwaye umgangatho wazo uchaphazela ngokuthe ngqo ukusebenza kwee-capsules ezithambileyo. Umzekelo, ukuvuza kwe-capsule shell, ukunamathela, ukuhamba kwezinto, ukubola kancinci, kunye nokunyibilika kwee-capsules ezithambileyo kwenzeka ngexesha lokugcina. Iingxaki ezifana nokungathobeli zinxulumene nayo.
Okwangoku, uninzi lwezinto zekhaphu zekhaphu zekhaphu ezithambileyo zamayeza kwilizwe lam ziyigelatin yezilwanyana, kodwa ngophuhliso olunzulu kunye nokusetyenziswa kweekhaphu ezithambileyo zegelatin, ukusilela kwayo kunye nokusilela kwayo kuye kwabonakala ngakumbi, njengemithombo enzima yezinto eziluhlaza, kunye neempendulo ezilula zokudibanisa kunye neekhompawundi ze-aldehyde Iingxaki zomgangatho ezifana nexesha elifutshane lokugcina kunye "nenkunkuma ezintathu" eziveliswa kwinkqubo yokucoca igelatin zinempembelelo enkulu kukhuseleko lokusingqongileyo. Ukongeza, kukwakho nengxaki yokuqina ebusika, okunempembelelo embi kumgangatho wokulungiselela. Kwaye iikhaphu ezithambileyo zegum yemifuno zinempembelelo encinci kwindalo esingqongileyo. Ngokuqhambuka kwezifo ezosulelayo ezivela kwizilwanyana kwihlabathi liphela, uluntu lwamazwe ngamazwe luxhalabile ngakumbi malunga nokhuseleko lweemveliso zezilwanyana. Xa kuthelekiswa neekhaphu zegelatin yezilwanyana, iikhaphu zezityalo zinezibonelelo ezibalaseleyo ngokubhekiselele ekusebenzeni, ukhuseleko, uzinzo, kunye nokhuseleko lokusingqongileyo.
Yongezai-hydroxypropyl methylcelluloseukumanzisa nokuchithachitha ukuze kufunyanwe isisombululo A; yongeza i-gelling agent, i-coagulant, i-plasticizer, i-opacifier kunye ne-colorant emanzini uze uchithe ukuze kufunyanwe isisombululo B; xuba izisombululo A kunye ne-B, uze ufudumale ukuya kuthi ga kwi-90 ~ 95°C, uvuselele kwaye ugcine ushushu kangangeeyure eziyi-0.5 ~ 2, uphole ukuya kuthi ga kwi-55 ~ 70°C, ugcine ushushu uze ume ukuze kukhutshwe iglu;
Indlela yokufumana ulwelo lweglue ngokukhawuleza, inkqubo ngokubanzi kukufudumala kancinci kwiketile yokusabela ixesha elide,
Abanye abavelisi badlula ngokukhawuleza kwi-colloid mill besebenzisa iglue yamakhemikhali
Ixesha leposi: Epreli-25-2024