Tam sim no, cov khoom siv raw ntawm cov tshuaj ntsiav cog feem ntau yog hydroxypropyl methylcellulose (HPMC) thiab pullulan, thiab hydroxypropyl hmoov txhuv nplej siab kuj tseem siv ua cov khoom siv raw.
Txij li thaum pib ntawm xyoo 2010s.HPMCtau siv rau hauv kev lag luam tsim tshuaj ntsiav hauv Suav teb, thiab raws li nws qhov kev ua tau zoo, HPMC hollow capsules tau nyob ruaj khov hauv kev lag luam capsule, qhia txog kev thov muaj zog hauv kaum xyoo dhau los.
Raws li cov ntaub ntawv kev lag luam, xyoo 2020, qhov muag khoom hauv tsev ntawm cov tshuaj ntsiav tawv hollow yuav yog li ntawm 200 billion capsules (kev lag luam tshuaj thiab khoom noj qab haus huv ua ke), uas qhov muag khoom ntawm HPMC capsules yuav yog li ntawm 11.3 billion capsules (suav nrog kev xa khoom tawm), nce 4.2% dhau xyoo 2019.%, suav txog li 5.5%. Kev lag luam tsis yog tshuaj suav txog 93.0% ntawm kev siv HPMC capsules hauv Suav teb, thiab kev loj hlob ntawm kev lag luam khoom kho mob tsav kev muag khoom ntawm HPMC capsules.
Txij xyoo 2020 txog 2025, CAGR ntawm HPMC capsules nrog cov neeg sawv cev gelling yuav yog 6.7%, uas siab dua li qhov kev loj hlob ntawm 3.8% rau gelatin capsules. Ntxiv mus, qhov kev thov rau HPMC capsules hauv kev lag luam khoom kho mob hauv tsev yog siab dua li hauv kev lag luam tshuaj.HPMCCov tshuaj ntsiav tuaj yeem pab tau nrog cov teeb meem kev sau tshuaj thiab ua kom haum rau cov kev nyiam kab lis kev cai thiab kev noj haus ntawm cov neeg siv khoom thoob plaws ntiaj teb. Txawm hais tias qhov kev thov tam sim no rau HPMC capsules tseem qis dua li ntawm cov tshuaj gelatin capsules, qhov kev loj hlob ntawm kev thov siab dua li ntawm cov tshuaj gelatin capsules.
1) Kev tsim cov qauv thiab cov txheej txheem tshiab, tsis muaj tus neeg sawv cev gelling; nws muaj kev yaj zoo dua, tus cwj pwm yaj tas li hauv ntau yam xov xwm sib txawv, tsis cuam tshuam los ntawm pH thiab ionic zog, thiab ua tau raws li cov kev xav tau ntawm cov tshuaj pharmacopoeia ntawm cov teb chaws loj thiab thaj chaw;
2) Rau cov ntsiab lus alkaline tsis muaj zog, txhim kho bioavailability thiab txhim kho cov tshuaj noj kom zoo dua;
3) Cov tsos zoo nkauj heev, thiab cov xim xaiv ntau dua.
Cov tshuaj ntsiav mos yog ib qho kev npaj ua los ntawm kev kaw cov roj lossis cov roj-raws li kev ncua hauv lub plhaub tshuaj ntsiav, thiab nws cov duab yog puag ncig, zoo li txiv ntseej, zoo li ntses me me, zoo li poob, thiab lwm yam. Nws yog tus cwj pwm los ntawm kev yaj lossis ncua cov khoom xyaw ua haujlwm hauv roj, uas muaj kev pib ua haujlwm sai dua thiab muaj bioavailability siab dua li ua cov khoom xyaw ua haujlwm zoo ib yam rau hauv cov ntsiav tshuaj, thiab tau siv dav hauv kev npaj cov khoom kho mob thiab tshuaj. Niaj hnub no, cov tshuaj ntsiav mos nrog cov yam ntxwv sib txawv xws li enteric-coated, chewable, osmotic twj tso kua mis, sustained-release, thiab cov tshuaj suppositories mos twb muaj nyob rau hauv kev ua lag luam. Lub plhaub tshuaj ntsiav mos yog tsim los ntawm colloid thiab cov khoom ntxiv. Ntawm lawv, colloids xws li gelatin lossis zaub gum yog cov khoom tseem ceeb, thiab lawv qhov zoo cuam tshuam ncaj qha rau kev ua haujlwm ntawm cov tshuaj ntsiav mos. Piv txwv li, capsule plhaub xau, adhesion, cov khoom tsiv teb tsaws chaw, qeeb qeeb disintegration, thiab yaj ntawm cov tshuaj ntsiav mos tshwm sim thaum lub sijhawm khaws cia Cov teeb meem xws li tsis ua raws li txoj cai yog cuam tshuam nrog nws.
Tam sim no, feem ntau ntawm cov khoom siv tshuaj ntsiav ntawm cov tshuaj ntsiav mos hauv kuv lub tebchaws yog cov tsiaj gelatin, tab sis nrog kev txhim kho tob thiab kev siv cov tshuaj ntsiav mos gelatin, nws qhov tsis txaus thiab qhov tsis zoo tau dhau los ua qhov tseem ceeb, xws li cov khoom siv raw khoom nyuaj, thiab yooj yim sib txuas cov tshuaj aldehyde. Cov teeb meem zoo xws li lub sijhawm khaws cia luv luv thiab "peb qhov pov tseg" tsim tawm hauv cov txheej txheem refining gelatin muaj kev cuam tshuam ntau dua rau kev tiv thaiv ib puag ncig. Tsis tas li ntawd, kuj tseem muaj teeb meem ntawm kev tawv thaum lub caij ntuj no, uas muaj kev cuam tshuam tsis zoo rau qhov zoo ntawm kev npaj. Thiab cov tshuaj ntsiav mos ntawm cov zaub muaj kev cuam tshuam tsawg dua rau ib puag ncig ib puag ncig. Nrog rau kev sib kis ntawm cov kab mob sib kis ntawm cov tsiaj txhu thoob plaws ntiaj teb, lub zej zog thoob ntiaj teb txhawj xeeb ntau ntxiv txog kev nyab xeeb ntawm cov khoom tsiaj. Piv nrog cov tshuaj ntsiav gelatin tsiaj, cov tshuaj ntsiav cog muaj qhov zoo tshaj plaws hauv kev siv tau, kev nyab xeeb, kev ruaj khov, thiab kev tiv thaiv ib puag ncig.
Ntxivhydroxypropyl methylcelluloserau dej thiab tawg kom tau txais cov kua A; ntxiv cov neeg sawv cev gelling, coagulant, plasticizer, opacifier thiab colorant rau hauv dej thiab tawg kom tau txais cov kua B; sib tov cov kua A thiab B, thiab cua sov txog li 90 ~ 95 ° C, do thiab ua kom sov rau 0.5 ~ 2 teev, txias txog li 55 ~ 70 ° C, ua kom sov thiab sawv ntsug rau defoaming kom tau txais cov kua nplaum;
Yuav ua li cas kom tau cov kua nplaum sai sai, cov txheej txheem dav dav yog kom sov qeeb qeeb hauv lub lauj kaub tshuaj tiv thaiv ntev,
Qee cov chaw tsim khoom sai sai dhau los ntawm lub tshuab colloid los ntawm cov kua nplaum tshuaj lom neeg
Lub sijhawm tshaj tawm: Plaub Hlis-25-2024