I-Hydroxypropyl methylcellulose (HPMC)yi-non-ionic cellulose ether esetyenziswa kakhulu kwizixhobo zokwakha, amayeza, ukutya, izinto zokuthambisa kunye neminye imboni. Izalathisi eziphambili zobugcisa ze-HPMC ziquka iipropati zomzimba nezekhemikhali, ukunyibilika, i-viscosity, inqanaba lokutshintshwa, njl.
1. Inkangeleko kunye neempawu ezisisiseko
I-HPMC idla ngokuba ngumgubo omhlophe okanye omhlophe qhwa, ayinavumba, ayinancasa, ayinatyhefu, inomnyibiliko olungileyo wamanzi kunye nozinzo. Ingasasazeka ngokukhawuleza kwaye inyibilike emanzini abandayo ukuze yenze isisombululo se-colloidal esicacileyo okanye esinamafu kancinci, kwaye ayinakunyibilika kakuhle kwizinyibilikisi zendalo.
2. Ukuxinana
Ukuqina koxinzelelo lolwelo yenye yezona mpawu zibalulekileyo zobugcisa ze-HPMC, nto leyo emisela ukusebenza kwe-AnxinCel®HPMC kwiindlela ezahlukeneyo zokusebenza. Ukuqina koxinzelelo lolwelo lwe-HPMC ngokuqhelekileyo kulinganiswa njengesisombululo samanzi esiyi-2% kwi-20°C, kwaye uluhlu oluqhelekileyo lokuqina koxinzelelo luqala kwi-5 mPa·s ukuya kwi-200,000 mPa·s. Okukhona ukuqina koxinzelelo kolwelo kuphezulu, kokukhona isiphumo sokuqina koxinzelelo lolwelo lwelo lolwelo siqina kwaye kokukhona i-rheology ingcono. Xa isetyenziswa kumashishini afana nokwakha kunye namayeza, umgangatho ofanelekileyo wokuqina koxinzelelo kufuneka ukhethwe ngokweemfuno ezithile.
3. Umxholo weMethoxy kunye neHydroxypropoxy
Iipropati zeekhemikhali ze-HPMC zimiselwa ikakhulu zii-degrees zayo zokutshintshwa kwe-methoxy (–OCH₃) kunye ne-hydroxypropoxy (–OCH₂CHOHCH₃). I-HPMC enama-degrees ahlukeneyo okutshintshwa ibonisa ukunyibilika okwahlukileyo, umsebenzi womphezulu kunye nobushushu be-gelation.
Umxholo weMethoxy: Ngokwesiqhelo phakathi kwe-19.0% kunye ne-30.0%.
Umxholo weHydroxypropoxy: Ngokwesiqhelo phakathi kwe-4.0% kunye ne-12.0%.
4. Umxholo wobumanzi
Umthamo wokufuma we-HPMC ngokubanzi ulawulwa kwi-≤5.0%. Umthamo wokufuma ophezulu uya kuchaphazela uzinzo kunye nefuthe lokusetyenziswa kwemveliso.
5. Umxholo wothuthu
Uthuthu yintsalela emva kokuba i-HPMC itshisiwe, ikakhulu evela kwiityuwa ezingaphiliyo ezisetyenziswa kwinkqubo yokuvelisa. Umxholo wothuthu uhlala ulawulwa kwi-≤1.0%. Umxholo ophezulu kakhulu wothuthu unokuchaphazela ukucaca kunye nobunyulu be-HPMC.
6. Ukunyibilika kunye nokungafihli nto
I-HPMC inokunyibilika kakuhle emanzini kwaye inokunyibilika ngokukhawuleza emanzini abandayo ukuze yenze isisombululo esifanayo se-colloidal. Ukucaca kwesisombululo kuxhomekeke kubunyulu be-HPMC kunye nenkqubo yayo yokunyibilika. Isisombululo se-HPMC esisemgangathweni ophezulu sidla ngokucaca okanye sibe nobisi kancinci.
7. Ubushushu beGel
Isisombululo samanzi se-HPMC siya kwenza ijeli kubushushu obuthile. Ubushushu bayo bejeli buhlala buphakathi kwama-50 nama-90°C, kuxhomekeke kubungakanani be-methoxy kunye ne-hydroxypropoxy. I-HPMC enomxholo ophantsi we-methoxy inobushushu obuphezulu bejeli, ngelixa i-HPMC enomxholo ophezulu we-hydroxypropoxy inobushushu obuphantsi bejeli.
8. Ixabiso le-pH
Ixabiso le-pH yesisombululo samanzi se-AnxinCel®HPMC lidla ngokuba phakathi kwe-5.0 kunye ne-8.0, esingathathi cala okanye esingena-alkaline kwaye sifanelekile kwiindawo ezahlukeneyo zokusetyenziswa.
9. Ubungakanani beParticles
Ubunzima be-HPMC buchazwa njengepesenti edlula kwisikrini se-80-mesh okanye se-100-mesh. Ngokuqhelekileyo kufuneka ukuba i-≥98% idlule kwisikrini se-80-mesh ukuqinisekisa ukuba inokusasazeka kakuhle kwaye iyanyibilika xa isetyenziswa.
10. Umxholo wesinyithi esinzima
Umxholo wesinyithi esinzima (njenge-lead kunye ne-arsenic) ye-HPMC kufuneka ihambelane nemigangatho efanelekileyo yoshishino. Ngokwesiqhelo, umxholo wesinyithi yi-≤10 ppm kwaye umxholo we-arsenic yi-≤3 ppm. Ingakumbi kwi-HPMC yokutya kunye ne-pharmacy grade, iimfuno zomxholo wesinyithi esinzima zingqongqo ngakumbi.
11. Izalathisi zeMicrobial
Kwi-AnxinCel®HPMC yamayeza kunye neyodidi lokutya, ungcoliseko lweentsholongwane kufuneka lulawulwe, kubandakanya inani elipheleleyo leekholoni, ukungunda, igwele, i-E. coli, njl.njl., ezidla ngokufuna:
Inani lilonke leekoloni ≤1000 CFU/g
Inani elipheleleyo lesikhunta kunye nemvubelo ≤100 CFU/g
I-E. coli, iSalmonella, njl. akufuneki zifunyanwe
12. Iindawo eziphambili zokusetyenziswa
I-HPMC isetyenziswa kakhulu kumashishini amaninzi ngenxa yokuba iqine, igcina amanzi, iyenza ifilimu, iyenza ithambe, iyenza i-emulsification kunye nezinye iimpawu:
Ishishini lokwakha: Njengesixhobo sokutyebisa nokugcina amanzi kwisamente, umgubo we-putty, i-tile adhesive, kunye ne-waterproof coating ukuphucula ukusebenza kolwakhiwo.
Ishishini leMithi: Lisetyenziswa njenge-glue, into ekhulula ixesha elide, kunye ne-capsule shell zixhobo zokwenza iipilisi zamayeza.
Ishishini lokutya: lisetyenziswa njenge-emulsifier, i-stabilizer, i-thickener, isetyenziswa kwi-jelly, iziselo, izinto ezibhakiweyo, njl.njl.
Ishishini leekhemikhali lemihla ngemihla: lisetyenziswa njengesithambisi kunye nesiqinisi se-emulsifier kwiimveliso zokhathalelo lolusu, iisepha, kunye neeshampu.
Izalathi zobugcisa zeI-HPMCziquka i-viscosity, inqanaba lokutshintsha (umxholo weqela ofakwe i-hydrolyzed), ukufuma, umxholo womlotha, ixabiso le-pH, ubushushu bejeli, ubuncinci, umxholo wesinyithi esinzima, njl. Ezi zibonakaliso zimisela ukusebenza kwayo kwiinkalo ezahlukeneyo. Xa ukhetha i-HPMC, abasebenzisi kufuneka bamisele iinkcukacha ezifanelekileyo ngokweemfuno ezithile zesicelo ukuqinisekisa isiphumo esifanelekileyo sokusetyenziswa.
Ixesha leposi: Feb-11-2025