Hydroxypropyl methylcellulose (HPMC)ndi ether ya cellulose yosakhala ionic yomwe imagwiritsidwa ntchito kwambiri mu zipangizo zomangira, mankhwala, chakudya, zodzoladzola ndi mafakitale ena. Zizindikiro zazikulu zaukadaulo za HPMC zimaphatikizapo katundu wakuthupi ndi wa mankhwala, kusungunuka, kukhuthala, kuchuluka kwa kusintha, ndi zina zotero.
1. Maonekedwe ndi makhalidwe oyambira
HPMC nthawi zambiri imakhala ufa woyera kapena wosakhala woyera, wopanda fungo, wopanda kukoma, wopanda poizoni, wokhala ndi madzi osungunuka bwino komanso wokhazikika. Imatha kufalikira mwachangu ndikusungunuka m'madzi ozizira kuti ipange yankho lowonekera kapena lopanda madzi pang'ono, ndipo imakhala ndi kusungunuka kochepa mu zosungunulira zachilengedwe.
2. Kukhuthala
Kukhuthala ndi chimodzi mwa zizindikiro zofunika kwambiri zaukadaulo za HPMC, zomwe zimatsimikiza momwe AnxinCel®HPMC imagwirira ntchito m'njira zosiyanasiyana. Kukhuthala kwa HPMC nthawi zambiri kumayesedwa ngati yankho lamadzi la 2% pa 20°C, ndipo kuchuluka kwa kukhuthala komwe kumapezeka nthawi zambiri kumakhala kuyambira 5 mPa·s mpaka 200,000 mPa·s. Kukhuthala komwe kumapezeka nthawi zambiri, mphamvu ya yankho imakula kwambiri ndipo rheology imakula bwino. Ikagwiritsidwa ntchito m'mafakitale monga zomangamanga ndi zamankhwala, kalasi yoyenera ya kukhuthala iyenera kusankhidwa malinga ndi zosowa zinazake.
3. Kuchuluka kwa Methoxy ndi Hydroxypropoxy
Kapangidwe ka mankhwala a HPMC kamadalira kwambiri madigiri ake osinthira a methoxy (–OCH₃) ndi hydroxypropoxy (–OCH₂CHOHCH₃). HPMC yokhala ndi madigiri osiyanasiyana osinthira imawonetsa kusungunuka kosiyana, ntchito ya pamwamba ndi kutentha kwa gelation.
Kuchuluka kwa Methoxy: Kawirikawiri pakati pa 19.0% ndi 30.0%.
Kuchuluka kwa Hydroxypropoxy: Kawirikawiri pakati pa 4.0% ndi 12.0%.
4. Kuchuluka kwa chinyezi
Chinyezi cha HPMC nthawi zambiri chimayendetsedwa pa ≤5.0%. Chinyezi chochuluka chimakhudza kukhazikika ndi momwe mankhwalawo amagwiritsidwira ntchito.
5. Phulusa
Phulusa ndi zotsalira za HPMC zikatenthedwa, makamaka kuchokera ku mchere wosapangidwa womwe umagwiritsidwa ntchito popanga. Kuchuluka kwa phulusa nthawi zambiri kumayendetsedwa pa ≤1.0%. Kuchuluka kwa phulusa kungakhudze kuwonekera bwino ndi kuyera kwa HPMC.
6. Kusungunuka ndi kuwonekera poyera
HPMC imasungunuka bwino m'madzi ndipo imatha kusungunuka mwachangu m'madzi ozizira kuti ipange yankho lofanana la colloidal. Kuwonekera bwino kwa yankho kumadalira kuyera kwa HPMC ndi njira yake yosungunukira. Yankho la HPMC labwino kwambiri nthawi zambiri limakhala lowonekera bwino kapena lofanana ndi mkaka pang'ono.
7. Kutentha kwa Gel
Madzi a HPMC amapanga gel pa kutentha kwina. Kutentha kwake kwa gel nthawi zambiri kumakhala pakati pa 50 ndi 90°C, kutengera kuchuluka kwa methoxy ndi hydroxypropoxy. HPMC yokhala ndi methoxy yochepa imakhala ndi kutentha kwakukulu kwa gel, pomwe HPMC yokhala ndi hydroxypropoxy yambiri imakhala ndi kutentha kochepa kwa gel.
8. pH mtengo
pH ya yankho lamadzi la AnxinCel®HPMC nthawi zambiri imakhala pakati pa 5.0 ndi 8.0, lomwe ndi lopanda mbali kapena lopanda mphamvu ya alkaline ndipo liyenera kugwiritsidwa ntchito m'malo osiyanasiyana.
9. Kukula kwa Tinthu
Kusalala kwa HPMC nthawi zambiri kumafotokozedwa ngati kuchuluka kwa madzi omwe amadutsa mu sikirini ya ma mesh 80 kapena ma mesh 100. Nthawi zambiri pamafunika kuti ≥98% idutse mu sikirini ya ma mesh 80 kuti zitsimikizire kuti imatha kusungunuka bwino ikagwiritsidwa ntchito.
10. Kuchuluka kwa zitsulo zolemera
Kuchuluka kwa zitsulo zolemera (monga lead ndi arsenic) za HPMC kuyenera kutsatira miyezo yoyenera yamakampani. Nthawi zambiri, kuchuluka kwa zitsulo zolemera ndi ≤10 ppm ndipo kuchuluka kwa arsenic ndi ≤3 ppm. Makamaka mu HPMC ya zakudya ndi mankhwala, zofunikira pa kuchuluka kwa zitsulo zolemera zimakhala zovuta kwambiri.
11. Zizindikiro za tizilombo toyambitsa matenda
Pa mankhwala ndi zakudya zamtundu wa AnxinCel®HPMC, kuipitsidwa kwa tizilombo toyambitsa matenda kuyenera kulamulidwa, kuphatikizapo kuchuluka kwa koloni, nkhungu, yisiti, E. coli, ndi zina zotero, zomwe nthawi zambiri zimafuna:
Chiwerengero chonse cha koloni ≤1000 CFU/g
Chiwerengero chonse cha nkhungu ndi yisiti ≤100 CFU/g
E. coli, Salmonella, ndi zina zotero siziyenera kupezeka
12. Malo ofunikira kwambiri
HPMC imagwiritsidwa ntchito kwambiri m'mafakitale ambiri chifukwa cha kukhuthala kwake, kusunga madzi, kupanga filimu, mafuta odzola, emulsification ndi zina zomwe zimapangitsa:
Makampani omanga: Monga chokhuthala komanso chosungira madzi mu simenti, ufa wa putty, guluu wa matailosi, ndi zokutira zosalowa madzi kuti ntchito yomanga iyende bwino.
Makampani opanga mankhwala: Amagwiritsidwa ntchito ngati guluu, chinthu chotulutsa zinthu nthawi zonse, komanso ngati chipolopolo cha kapisozi chomwe chimagwiritsidwa ntchito popanga mapiritsi a mankhwala.
Makampani azakudya: amagwiritsidwa ntchito ngati emulsifier, stabilizer, thickener, amagwiritsidwa ntchito mu jelly, zakumwa, zinthu zophikidwa, ndi zina zotero.
Makampani opanga mankhwala tsiku ndi tsiku: amagwiritsidwa ntchito ngati chowonjezera komanso chokhazikika cha emulsifier mu zinthu zosamalira khungu, sopo, ndi shampu.
Zizindikiro zaukadaulo zaHPMCkuphatikizapo kukhuthala, kuchuluka kwa kusintha (kuchuluka kwa gulu la hydrolyzed), chinyezi, kuchuluka kwa phulusa, pH, kutentha kwa gel, kusalala, kuchuluka kwa zitsulo zolemera, ndi zina zotero. Zizindikiro izi zimatsimikiza momwe imagwiritsidwira ntchito m'magawo osiyanasiyana. Posankha HPMC, ogwiritsa ntchito ayenera kudziwa zofunikira zoyenera malinga ndi zofunikira zinazake zogwiritsira ntchito kuti atsimikizire kuti ntchitoyo ndi yabwino kwambiri.
Nthawi yotumizira: Feb-11-2025