Tam sim no, cov ntaub ntawv nyoos ntawm cov tshuaj ntsiav tshuaj yog hydroxypropyl methylcellulose (HPMC) thiab rubulan, thiab hydroxypropyl starch kuj tseem siv los ua raw khoom.
Txij li thaum pib xyoo 2010,HPMCtau siv nyob rau hauv Suav cog tshuaj ntsiav tshuaj kev lag luam, thiab raws li nws cov kev ua tau zoo, HPMC hollow capsules tau ruaj khov nyob rau hauv ib qho chaw nyob rau hauv lub capsule kev ua lag luam, qhia tau hais tias muaj zog thov nyob rau hauv lub xyoo caum dhau los nce.
Raws li cov ntaub ntawv kev lag luam, xyoo 2020, kev muag khoom hauv tsev ntim ntawm hollow hard capsules yuav yog li ntawm 200 billion capsules (kev lag luam tshuaj thiab kev noj qab haus huv cov khoom lag luam ua ke), ntawm qhov muag ntim ntawm HPMC capsules yuav yog kwv yees li 11.3 billion capsules (suav nrog kev xa tawm), nce ntawm 4.2% tshaj 2019. 5%. Kev lag luam tsis yog tshuaj suav nrog 93.0% ntawm kev noj HPMC cov tshuaj ntsiav hauv Suav teb, thiab kev loj hlob ntawm kev lag luam khoom noj khoom haus ua rau kev muag khoom ntawm HPMC capsules.
Los ntawm 2020 txog 2025, CAGR ntawm HPMC capsules nrog cov tshuaj gelling yuav tsum yog 6.7%, uas yog siab dua qhov kev loj hlob ntawm 3.8% rau gelatin capsules. Ntxiv mus, qhov kev thov rau HPMC capsules nyob rau hauv domestic kev kho mob cov khoom lag luam kev lag luam yog siab dua li nyob rau hauv kev lag luam tshuaj.HPMCcapsules tuaj yeem pab nrog cov kev sib tw ntawm cov ntawv sau tshuaj thiab ua raws li kev cai thiab kev noj haus nyiam ntawm cov neeg siv khoom thoob ntiaj teb. Txawm hais tias qhov kev thov tam sim no rau HPMC capsules tseem qis dua li ntawm gelatin capsules, qhov kev loj hlob ntawm kev thov yog siab dua li ntawm gelatin capsules.
1) Kev tsim thiab txheej txheem, tsis muaj gelling tus neeg sawv cev; nws muaj kev zoo dua solubility, zoo ib yam dissolution tus cwj pwm nyob rau hauv sib txawv xov xwm, tsis cuam tshuam los ntawm pH thiab ionic zog, thiab ua tau raws li lub pharmacopoeia yuav tsum tau ntawm lub teb chaws loj thiab cheeb tsam;
2) Rau cov ntsiab lus tsis muaj zog alkaline, txhim kho bioavailability thiab txhim kho daim ntawv ntau npaum li cas;
3) Lub ntsej muag zoo nkauj, thiab kev xaiv xim muaj ntau dua.
Mos capsule yog ib qho kev npaj tsim los ntawm sealing roj los yog roj-raws li ncua kev kawm ntawv nyob rau hauv lub capsule plhaub, thiab nws cov duab yog puag ncig, txiv ntseej-puab, me me ntses-puab, poob-shaped, thiab lwm yam. Niaj hnub no, cov tshuaj ntsiav mos uas muaj cov yam ntxwv sib txawv xws li enteric-coated, chewable, osmotic twj tso kua mis, sustained-tso tawm, thiab cov suppositories mos twb muaj nyob rau hauv kev ua lag luam. Cov mos mos capsule plhaub yog tsim los ntawm colloid thiab auxiliary additives. Ntawm lawv, colloids xws li gelatin lossis zaub pos hniav yog cov khoom tseem ceeb, thiab lawv qhov zoo cuam tshuam ncaj qha rau kev ua haujlwm ntawm cov tshuaj ntsiav mos. Piv txwv li, capsule plhaub to, adhesion, cov khoom tsiv teb tsaws, qeeb disintegration, thiab dissolution ntawm mos capsules tshwm sim thaum lub sij hawm cia cov teeb meem xws li tsis ua raws li nws muaj feem xyuam rau.
Tam sim no, feem ntau ntawm cov khoom siv tshuaj ntsiav tshuaj hauv kuv lub teb chaws yog tsiaj gelatin, tab sis nrog rau qhov kev loj hlob thiab kev siv cov gelatin mos capsules, nws qhov tsis zoo thiab qhov tsis zoo tau dhau los ua qhov tseem ceeb, xws li cov khoom siv raw, thiab kev sib txuas yooj yim nrog cov aldehyde compounds Cov teeb meem zoo xws li cov txheej txheem gelatin luv luv thiab cov txheej txheem reth. ntawm kev tiv thaiv ib puag ncig. Tsis tas li ntawd, tseem muaj qhov teeb meem ntawm hardening nyob rau lub caij ntuj no, uas muaj kev cuam tshuam tsis zoo rau qhov zoo ntawm kev npaj. Thiab zaub cov pos hniav mos capsules muaj kev cuam tshuam tsawg dua rau ib puag ncig ib puag ncig. Nrog rau kev ua tiav ntawm cov kab mob sib kis ntawm cov tsiaj keeb kwm thoob ntiaj teb, cov zej zog thoob ntiaj teb tau txhawj xeeb ntxiv txog kev nyab xeeb ntawm cov khoom tsiaj. Piv nrog rau tsiaj gelatin capsules, cov tshuaj ntsiav tshuaj muaj qhov zoo tshaj plaws ntawm kev siv tau, kev nyab xeeb, ruaj khov, thiab kev tiv thaiv ib puag ncig.
NtxivHydroxypropyl methylcellulose yog tsim los ntawm cov tshuajdej thiab tawg mus kom tau txais kev daws A; ntxiv gelling tus neeg sawv cev, coagulant, plasticizer, opacifier thiab colorant rau dej thiab disperse kom tau cov tshuaj B; sib tov cov ntsiab lus A thiab B, thiab kub txog 90 ~ 95 ° C, do thiab ua kom sov li 0.5 ~ 2h, txias rau 55 ~ 70 ° C, kom sov thiab sawv ntsug rau defoaming kom tau cov kua nplaum;
Yuav ua li cas kom tau cov kua nplaum sai sai, cov txheej txheem dav dav yog kom sov maj mam hauv cov tshuaj tiv thaiv kab mob rau lub sijhawm ntev,
Qee cov tuam txhab lag luam sai dhau los ntawm lub tshuab colloid los ntawm cov kua nplaum tshuaj
Lub sij hawm xa tuaj: Plaub Hlis-25-2024