I-Hydroxypropyl methyl cellulose HPMC, eyaziwa nangokuthi i-hydroxypromellose, iyimpuphu noma i-granule ye-cellulose emhlophe kuya kwemhlophe enomswakama wamanzi abandayo kanye nokungancibiliki kwamanzi ashisayo okufana ne-methyl cellulose. Iqembu le-hydroxypropyl kanye neqembu le-methyl kuyisibopho se-ether kanye nendandatho ye-glucose engamanzi ye-cellulose ehlanganisiwe, uhlobo lwe-non-ionic cellulose mixed ether. Iyi-polymer ehlanganisiwe, engasebenzi, ene-viscoelastic evame ukusetshenziswa njenge-lubricant ku-ophthalmology, noma njenge-excipient noma i-excipient emithini yomlomo.
1. Inqubo yokukhiqiza
I-pulp ye-Kraft enokuqukethwe kwe-αcellulose okungu-97%, i-viscosity yangaphakathi engu-720mL /g kanye nobude obumaphakathi be-fiber obungu-2.6mm yacwiliswa kusisombululo se-NaOH esingu-49% ku-40℃ imizuzwana engu-50. Ngemuva kwalokho i-pulp yakhishwa ukuze kususwe isisombululo se-NaOH esingu-49% esengeziwe ukuze kutholakale i-alkali cellulose. Isilinganiso sesisindo (isisombululo samanzi esingu-49% se-NaOH) kuya (ingxenye eqinile ye-pulp) esinyathelweni sokufakwa sasingu-200. Isilinganiso sesisindo se-NaOH ku-alkali cellulose kuya ku-solid ku-pulp siyi-1.49. I-alkali cellulose etholakale ngaleyo ndlela (20kg) ifakwa ku-reactor yokucindezela eboshwe nge-internal agitation, bese ihlanzwa nge-vacuum futhi ihlanzwe nge-nitrogen ukuze kususwe umoya-mpilo ngokwanele ku-reactor. Ngemuva kwalokho, izinga lokushisa ku-reactor lalawulwa ku-60℃ ngenkathi kwenziwa ukuxubana kwangaphakathi.
Kwabe sekufakwa i-2.4kg dME futhi izinga lokushisa ku-reactor lalawulwa laya ku-60℃. Ngemva kokwengezwa kwe-dimethyl ether, kwafakwa i-methylene chloride ukuze kwenziwe isilinganiso se-molar se-methylene chloride ku-NaOH ku-alkaline cellulose 1.3, kwafakwa i-propylene oxide ukuze kwenziwe isilinganiso sesisindo se-propylene oxide ku-solid ku-pulp 1.97, kanti izinga lokushisa ku-reactor lalawulwa kusukela ku-60℃ kuya ku-80℃. Ngemva kokufaka i-chloromethane ne-propylene oxide, izinga lokushisa ku-reactor lalawulwa kusukela ku-80℃ kuya ku-90℃. Ngaphezu kwalokho, ukusabela kwahlala imizuzu engama-20 ku-90℃.
Igesi bese ikhishwa ku-reactor bese i-crude hydroxypropyl methyl cellulose isuswa ku-reactor. Izinga lokushisa le-crude hydroxypropyl methyl cellulose lalingu-62℃. Kala usayizi wezinhlayiya ezingu-50% ezihlanganisiwe ekusabalalisweni kosayizi wezinhlayiya ezisekelwe esisindweni esihlanganisiwe ngokusekelwe esilinganisweni se-crude hydroxypropyl methyl cellulose ngokusebenzisa izikhala ze-sieving ezinhlanu, ngayinye inosayizi ohlukile wokuvula.
Ngenxa yalokho, usayizi ojwayelekile wezinhlayiya zezinhlayiya eziqinile wawungu-6.2mm. I-crude hydroxypropyl methyl cellulose etholiwe yafakwa ku-continuous biaxial kneader (i-KRC kneader S1, L/D = 10.2, ivolumu yangaphakathi engu-0.12 L, isivinini sokujikeleza esingu-150rpm) ngesivinini esingu-10kg/hr, kwathi kwatholakala i-crude hydroxypropyl methyl cellulose ebolile. Ngenxa yokulinganisa okufanayo kusetshenziswa izikrini ezi-5 ezinobukhulu obuhlukene bokuvula, usayizi ojwayelekile wezinhlayiya wawungu-1.4mm. Ukwengeza amanzi ashisayo angu-80℃ ku-crude hydroxypropyl methyl cellulose ebolile ethangini ngokulawula izinga lokushisa kwejakethi. inani lesilinganiso sesisindo se-crude hydroxypropyl methyl cellulose ebolile enanini eliphelele le-slurry lingu-0.1, kanti i-slurry iyatholakala. I-slurry ivuselelwe ekushiseni okungaguquki okungu-80℃ imizuzu engama-60.
Ngemuva kwalokho, i-slurry inikezwa ngesivinini esijikelezayo esingu-0.5 RPM kanye nesihlungi sokucindezela esijikelezayo esishisiwe (imikhiqizo ye-BHS Sonthofen). Izinga lokushisa le-grout lingu-93℃. Sebenzisa iphampu ukuze unikeze i-slurry, ingcindezi yokukhipha iphampu ingu-0.2mpa. Usayizi wokuvula wesihlungi sokucindezela esijikelezayo ungu-80μm, kanti indawo yesihlungi ingu-0.12m2. I-slurry enikezwa kusihlungi sokucindezela esijikelezayo ihlungwa ngesihlungi bese iguqulwa ibe yikhekhe lesihlungi. Ikhekhe lesihlungi eliphumayo linikezwa umusi ongu-0.3mpa kanye namanzi ashisayo angu-95℃ anesilinganiso sesisindo esingu-10.0 engxenyeni eqinile ye-HYDROXYpropyl methyl cellulose ehlanziwe, bese ihlungwa ngesihlungi.
Amanzi ashisayo anikezwa ngepompo ngomfutho wokukhipha ongu-0.2mpa. Ngemva kokunikezwa kwamanzi ashisayo, kunikezwa umusi ongu-0.3mpa. Ngemuva kwalokho, ngemva kokukhishwa kwemikhiqizo yokuwasha isuswa endaweni yesihlungi ngesikrufu bese ikhishwa emshinini wokuwasha. Izinyathelo kusukela ekuhlinzekeni i-slurry kuya ekukhipheni imikhiqizo ehlanziwe zenziwa njalo. Njengoba kulinganiswa kusetshenziswa i-hygrometer yokushisa-yokomisa, okuqukethwe kwamanzi komkhiqizo ohlanziwe ngaleyo ndlela kwakungu-52.8%. Imikhiqizo ehlanziwe ekhishwe esihlungini sokucindezela esijikelezayo yomiswa nge-air dryer ku-80℃, yabe isichotshozwa e-Victory mill ukuze kutholakale i-hydroxypropyl methyl cellulose.
2. Isicelo
I-HPMCUmkhiqizo usetshenziswa njengesithambisi, isihlakazi, isihlanganisi, i-emulsifier kanye nesiqinisi embonini yezindwangu. Usetshenziswa kabanzi futhi ku-resin yokwenziwa, i-petrochemical, i-ceramic, iphepha, isikhumba, imithi, ukudla, izimonyo kanye neminye imboni.
Isikhathi sokuthunyelwe: Ephreli-26-2024