Hydroxypropyl methyl cellulose HPMC, yomwe imadziwikanso kuti hydroxypromellose, ndi ufa wa ether wa cellulose woyera kapena wosakhala woyera womwe uli ndi kusungunuka kwa madzi ozizira komanso kusasungunuka kwa madzi otentha kofanana ndi methyl cellulose. Gulu la Hydroxypropyl ndi gulu la methyl ndi ether bond ndi anhydrous glucose ring ya cellulose yophatikizidwa, ndi mtundu wa non-ionic cellulose mixed ether. Ndi semi-synthetic, interactive, viscoelastic polymer yomwe imagwiritsidwa ntchito kwambiri ngati mafuta mu ophthalmology, kapena ngati excipient kapena excipient mu mankhwala omwa.
1. Njira yopangira
Kraft pulp yokhala ndi αcellulose ya 97%, kukhuthala kwamkati kwa 720mL /g ndi ulusi wapakati wa 2.6mm inanyowetsedwa mu yankho la 49% NaOH pa 40℃ kwa masekondi 50. Kenako pulp inatulutsidwa kuti ichotse yankho la 49% NaOH lowonjezera kuti ipeze alkali cellulose. Chiŵerengero cha kulemera kwa (49% NaOH aqueous solution) ku (gawo lolimba la pulp) mu gawo la impregnation chinali 200. Chiŵerengero cha kulemera kwa NaOH mu alkali cellulose ku cholimba mu pulp ndi 1.49. Alkali cellulose yomwe imapezeka (20kg) imayikidwa mu jacket pressure reactor yokhala ndi internal agnition, kenako imatsukidwa ndi vacuum ndikutsukidwa ndi nayitrogeni kuti ichotse mpweya wokwanira mu reactor. Kenako, kutentha kwa reactor kunayang'aniridwa pa 60℃ pamene internal agnition inkachitika.
Kenako 2.4kg dME inawonjezedwa ndipo kutentha mu reactor kunawongoleredwa kufika pa 60℃. Pambuyo powonjezera dimethyl ether, methylene chloride inawonjezedwa kuti ipange chiŵerengero cha molar cha methylene chloride ku NaOH mu alkaline cellulose 1.3, propylene oxide inawonjezedwa kuti ipange chiŵerengero cha kulemera kwa propylene oxide ku cholimba mu pulp 1.97, ndipo kutentha mu reactor kunawongoleredwa kuyambira 60℃ mpaka 80℃. Pambuyo powonjezera chloromethane ndi propylene oxide, kutentha mu reactor kunawongoleredwa kuyambira 80℃ mpaka 90℃. Kuphatikiza apo, kuyankhako kunatenga mphindi 20 pa 90℃.
Mpweyawo umachotsedwa mu reaktara ndipo crude hydroxypropyl methyl cellulose imachotsedwa mu reaktara. Kutentha kwa crude hydroxypropyl methyl cellulose kunali 62℃. Yesani kukula kwa tinthu tating'onoting'ono ta 50% mu kugawa kwa tinthu tating'onoting'ono tomwe timagawika potengera chiŵerengero cha crude hydroxypropyl methyl cellulose kudzera m'mabowo a sieving asanu, iliyonse ili ndi kukula kosiyana.
Zotsatira zake, kukula kwa tinthu tating'onoting'ono ta tinthu tating'onoting'ono ta coarse timene tinkapezeka kunali 6.2mm. Crude hydroxypropyl methyl cellulose yomwe inapezeka inalowetsedwa mu continuous biaxial kneader (KRC kneader S1, L/D = 10.2, internal volume 0.12 L, rotation speed 150rpm) pa liwiro la 10kg/hr, ndipo crude hydroxypropyl methyl cellulose yomwe inawonongeka inapezeka. Chifukwa cha miyeso yofanana pogwiritsa ntchito ma screen 5 okhala ndi kukula kosiyanasiyana, crude hydroxypropyl methyl cellulose yomwe inawonongeka inali 1.4mm. Kuwonjezera madzi otentha a 80℃ ku crude hydroxypropyl methyl cellulose yomwe inawonongeka mu thanki ndi kutentha kwa jekete. Kuchuluka kwa kulemera kwa crude hydroxypropyl methyl cellulose yomwe inawonongeka ndi kuchuluka konse kwa crude ndi 0.1, ndipo crude imapezedwa. Crude inasunthidwa pa kutentha kosasintha kwa 80℃ kwa mphindi 60.
Kenako, slurry imaperekedwa ku liwiro lozungulira la 0.5 RPM ndi fyuluta yozungulira yotenthedwa kale (zogulitsa za BHS Sonthofen). Kutentha kwa grout ndi 93℃. Gwiritsani ntchito pampu kuti mupereke slurry, kuthamanga kwa kutulutsa kwa pampu ndi 0.2mpa. Kukula kotsegulira kwa fyuluta yozungulira ndi 80μm, ndipo malo osungiramo fyuluta ndi 0.12m2. Slurry yomwe imaperekedwa ku fyuluta yozungulira imasefedwa kudzera mu fyuluta ndikusandulika keke yosefedwa. Keke yotulutsira yomwe imachokera imaperekedwa ndi nthunzi ya 0.3mpa ndi madzi otentha a 95℃ okhala ndi chiŵerengero cha kulemera cha 10.0 ku gawo lolimba la HYDROXYpropyl methyl cellulose yotsukidwa, yomwe kenako imasefedwa kudzera mu fyuluta.
Madzi otentha amaperekedwa kudzera mu pampu pa mphamvu yotulutsa ya 0.2mpa. Madzi otentha akaperekedwa, nthunzi ya 0.3mpa imaperekedwa. Kenako, zinthu zotsukira zimachotsedwa pamwamba pa fyuluta ndi chotsukira ndikutulutsidwa mu makina ochapira. Masitepe kuyambira popereka slurry mpaka kutulutsa zinthu zotsukira zimachitika mosalekeza. Monga momwe zimayesedwera pogwiritsa ntchito heat-dryer hygrometer, kuchuluka kwa madzi mu chinthu chotsukiracho komwe kumatulutsidwa kunali 52.8%. Zinthu zotsukira zomwe zimatulutsidwa mu fyuluta yozungulira zimaumitsidwa ndi chowumitsira mpweya pa 80℃, ndikuphwanyidwa mu Victory mill kuti mupeze hydroxypropyl methyl cellulose.
2. Kugwiritsa Ntchito
HPMCChogulitsachi chimagwiritsidwa ntchito ngati chokhuthala, chosungunula, chomangirira, chosakaniza ndi chokhazikika m'makampani opanga nsalu. Chimagwiritsidwanso ntchito kwambiri mu utomoni wopangidwa, petrochemical, ceramic, mapepala, chikopa, mankhwala, chakudya, zodzoladzola ndi mafakitale ena.
Nthawi yotumizira: Epulo-26-2024