Hydroxypropyl methyl cellulose HPMC, e mōhiotia ana ko te hydroxypromellose, he paura, he kirikiri rānei mai i te cellulose ether mā ki te mā, he rite te wairewa ki te wai matao, ā, he rite te kore wairewa ki te methyl cellulose i roto i te wai wera. Ko te rōpū hydroxypropyl me te rōpū methyl he hononga ether me te mowhiti hukahuka anhydrous o te cellulose kua whakakotahihia, he momo cellulose kore-ionic kua whakaranua ki te ether. He polymer viscoelastic haurua-hanga, kore mahi, e whakamahia whānuitia ana hei hinu whakahinuhinu i roto i te ophthalmology, hei excipient rānei i roto i ngā rongoā ā-waha.
1. Te tukanga whakaputa
I rumakina te penupenu Kraft me te ihirangi αcellulose o te 97%, te matotoru ā-roto o te 720mL/g me te roa muka toharite o te 2.6mm ki roto i te otinga 49% NaOH i te 40℃ mō te 50 hēkona. Kātahi ka whakaputahia te penupenu hei tango i te otinga 49% NaOH taikaha hei tiki i te cellulose alkali. Ko te ōwehenga taumaha o te (49% otinga wai NaOH) ki (te wāhanga totoka o te penupenu) i te taahiraa whakakī he 200. Ko te ōwehenga taumaha o te NaOH i roto i te cellulose alkali ki te totoka i roto i te penupenu he 1.49. Ko te cellulose alkali i whiwhihia (20kg) ka whakanohoia ki roto i te tauhohenga pēhanga kua whakapikohia me te whakaoho ā-roto, kātahi ka whakakorengia, ka horoia ki te hauota hei tango tika i te hāora mai i te tauhohenga. Kātahi ka whakahaeretia te pāmahana i roto i te tauhohenga ki te 60℃ i te wā e whakahaerehia ana te whakaoho ā-roto.
Kātahi ka tāpirihia he 2.4kg dME, ā, ka whakahaeretia te pāmahana i roto i te tauhohenga ki te 60℃. Whai muri i te tāpiritanga o te dimethyl ether, ka tāpirihia te methylene chloride kia puta ai te ōwehenga molar o te methylene chloride ki te NaOH i roto i te cellulose alkaline 1.3, ka tāpirihia te propylene oxide kia puta ai te ōwehenga taumaha o te propylene oxide ki te totoka i roto i te penupenu 1.97, ā, ka whakahaeretia te pāmahana i roto i te tauhohenga mai i te 60℃ ki te 80℃. Whai muri i te tāpiritanga o te chloromethane me te propylene oxide, ka whakahaeretia te pāmahana i roto i te tauhohenga mai i te 80℃ ki te 90℃. Hei tāpiritanga, i roa te tauhohenga mō te 20 meneti i te 90℃.
Kātahi ka ringihia te hau mai i te tauhohenga, ā, ka tangohia te hydroxypropyl methyl cellulose mata mai i te tauhohenga. Ko te pāmahana o te hydroxypropyl methyl cellulose mata he 62℃. Inehia te 50% o te rahi matūriki i roto i te taumaha whakaemi i runga i te tohatoha rahi matūriki i runga i te ōwehenga o te hydroxypropyl methyl cellulose mata mā roto i ngā pūaha o ngā tātari e rima, he rerekē te rahi o te pūaha o ia pūaha.
Nō reira, ko te rahi toharite o ngā matūriki matotoru he 6.2mm. Ko te hydroxypropyl methyl cellulose mata i whiwhihia i whakaurua ki roto i te mīhini pokepoke biaxial tonu (KRC kneader S1, L/D = 10.2, rōrahi ā-roto 0.12 L, tere hurihuri 150rpm) i te tere o te 10kg/hr, ā, i whiwhihia te hydroxypropyl methyl cellulose mata kua pirau. Nā ngā inenga ōrite mā te whakamahi i ngā mata e 5 me ngā rahi whakatuwheratanga rerekē, ko te rahi toharite o te matūriki he 1.4mm. Mā te tāpiri i te wai wera 80℃ ki te hydroxypropyl methyl cellulose mata kua pirau i roto i te tāke me te whakahaere pāmahana o te koti. Ko te nui o te ōwehenga taumaha o te hydroxypropyl methyl cellulose mata kua pirau ki te nui katoa o te paru he 0.1, ā, ka whiwhihia te paru. I whakaohokia te paru i te pāmahana pumau o te 80℃ mō te 60 meneti.
Kātahi ka tukuna te paru ki te tere hurihuri o te 0.5 RPM me te tātari pēhanga hurihuri kua whakamahanahia (ngā hua BHS Sonthofen). Ko te pāmahana o te kūmara he 93℃. Whakamahia he papu hei tuku i te paru, ko te pēhanga tukunga papu he 0.2mpa. Ko te rahi whakatuwheratanga o te tātari pēhanga hurihuri he 80μm, ā, ko te horahanga tātari he 0.12m2. Ko te paru e tukuna ana ki te tātari pēhanga hurihuri ka tātarihia mā te tātari ka hurihia hei keke tātari. Ko te keke tātari hua ka tukuna ki te mamaoa 0.3mpa me te wai wera 95℃ me te ōwehenga taumaha o te 10.0 ki te wāhanga totoka o te HYDROXYpropyl methyl cellulose kua horoia, kātahi ka tātarihia mā te tātari.
Ka tukuna te wai wera mā te papu i te pēhanga tukunga o te 0.2mpa. I muri i te tukuna o te wai wera, ka tukuna te mamaoa 0.3mpa. Kātahi, i muri i te horoinga, ka tangohia ngā hua mai i te mata tātari mā te waru, ka tukuna ki waho o te mīhini horoi. Ka mahia tonutia ngā mahi mai i te tuku i te paru ki te tuku i ngā hua kua horoia. E ai ki te ine mā te whakamahi i te hygrometer whakamaroke wera, ko te nui o te wai o te hua kua horoia i tukuna ko te 52.8%. Ko ngā hua kua horoia i tukuna mai i te tātari pēhanga hurihuri i whakamarokehia e te whakamaroke hau i te 80℃, ā, i kuruhia ki roto i te mira Victory kia whiwhi ai i te hydroxypropyl methyl cellulose.
2. Tono
HPMCE whakamahia ana te hua hei whakamātotoru, hei whakamarara, hei here, hei whakapūmau me te whakau i roto i te umanga kakahu. E whakamahia whānuitia ana hoki i roto i te kapia hangai, te hinu matū, te uku, te pepa, te hiako, te rongoā, te kai, ngā mea whakapaipai me ētahi atu umanga.
Wā tuku: Paenga-whāwhā-26-2024