ʻO ka Hydroxypropyl methyl cellulose HPMC, i ʻike ʻia hoʻi ʻo hydroxypromellose, he pauka cellulose ether keʻokeʻo a keʻokeʻo paha i loaʻa ka solubility i ka wai anuanu a me ka insolubility i ka wai wela e like me ka methyl cellulose. ʻO ka hui Hydroxypropyl a me ka hui methyl he ether bond a me ke apo glucose anhydrous o ka cellulose i hui pū ʻia, he ʻano o ka hui cellulose non-ionic i hui ʻia me ka ether. He polymer semi-synthetic, hana ʻole, viscoelastic i hoʻohana pinepine ʻia ma ke ʻano he lubricant i ka ophthalmology, a i ʻole he excipient a excipient paha i nā lāʻau lapaʻau waha.
1. Ke kaʻina hana
Ua hoʻomoʻa ʻia ka pulp Kraft me ka nui o ka αcellulose o 97%, ka viscosity intrinsic o 720mL /g a me ka lōʻihi o ke fiber awelika o 2.6mm i loko o ka 49% NaOH solution ma 40℃ no 50 kekona. A laila ua hoʻopuka ʻia ka pulp e wehe i ka 49% NaOH solution keu e loaʻa ai ka cellulose alkali. ʻO ka lakio kaumaha o (49% NaOH aqueous solution) i (ka ʻāpana paʻa o ka pulp) i ke kaʻina impregnation he 200. ʻO ka lakio kaumaha o NaOH i loko o ka alkali cellulose i ka paʻa i loko o ka pulp he 1.49. ʻO ka cellulose alkali i loaʻa pēlā (20kg) ua waiho ʻia i loko o kahi reactor kaomi jacked me ka hoʻouluulu kūloko, a laila vacuumed a hoʻomaʻemaʻe ʻia me ka nitrogen e wehe pono i ka oxygen mai ka reactor. A laila, ua hoʻomalu ʻia ka mahana i loko o ka reactor ma 60℃ ʻoiai e hana ʻia ana ka hoʻouluulu kūloko.
A laila ua hoʻohui ʻia he 2.4kg dME a ua hoʻomalu ʻia ka mahana i loko o ka reactor i 60 ℃. Ma hope o ka hoʻohui ʻana o ka dimethyl ether, ua hoʻohui ʻia ka methylene chloride e hana i ka ratio molar o ka methylene chloride i NaOH i loko o ka alkaline cellulose 1.3, ua hoʻohui ʻia ka propylene oxide e hana i ka ratio kaumaha o ka propylene oxide i ka paʻa i loko o ka pulp 1.97, a ua hoʻomalu ʻia ka mahana i loko o ka reactor mai 60 ℃ a i 80 ℃. Ma hope o ka hoʻohui ʻana i ka chloromethane a me ka propylene oxide, ua hoʻomalu ʻia ka mahana i loko o ka reactor mai 80 ℃ a i 90 ℃. Eia kekahi, ua mau ka hopena no 20 mau minuke ma 90 ℃.
A laila hoʻokahe ʻia ke kinoea mai ka reactor a lawe ʻia ka hydroxypropyl methyl cellulose maka mai ka reactor. ʻO ka mahana o ka hydroxypropyl methyl cellulose maka he 62℃. E ana i ka nui o ka ʻāpana 50% i ka hoʻolaha nui ʻana o ka nui o ka ʻāpana i ke kaumaha kumulative e pili ana i ka lakio o ka hydroxypropyl methyl cellulose maka ma o nā puka o nā sieving ʻelima, he ʻokoʻa ka nui o ka puka o kēlā me kēia.
ʻO ka hopena, ʻo ka awelika o ka nui o nā ʻāpana ʻāwiliwili he 6.2mm. Ua hoʻokomo ʻia ka hydroxypropyl methyl cellulose maka i loaʻa i loko o kahi kneader biaxial hoʻomau (KRC kneader S1, L/D = 10.2, ka nui o loko 0.12 L, ka wikiwiki o ka hoʻohuli ʻana he 150rpm) ma ka wikiwiki o 10kg/hr, a ua loaʻa ka hydroxypropyl methyl cellulose maka i hoʻopau ʻia. Ma muli o nā ana like me ka hoʻohana ʻana i 5 mau pale me nā nui wehe like ʻole, ʻo ka awelika o ka nui o nā ʻāpana he 1.4mm. Ke hoʻohui nei i ka wai wela 80℃ i ka hydroxypropyl methyl cellulose maka i hoʻopau ʻia i loko o ka pahu me ka kaohi mahana o ka ʻaʻahu. ʻo ka nui o ka lakio kaumaha o ka hydroxypropyl methyl cellulose maka i hoʻopau ʻia i ka nui o ka slurry he 0.1, a ua loaʻa ka slurry. Ua hoʻoulu ʻia ka slurry ma kahi mahana mau o 80℃ no 60 mau minuke.
A laila, hoʻolako ʻia ka slurry i ka wikiwiki wili o 0.5 RPM a me ke kānana kaomi wili i hoʻomehana mua ʻia (nā huahana BHS Sonthofen). ʻO ka mahana o ka grout he 93 ℃. E hoʻohana i ka pamu e hoʻolako i ka slurry, ʻo ke kaomi hoʻokuʻu pamu he 0.2mpa. ʻO ka nui o ka wehe ʻana o ke kānana kaomi wili he 80μm, a ʻo ka ʻāpana kānana he 0.12m2. Kānana ʻia ka slurry i hoʻolako ʻia i ke kānana kaomi wili ma o ke kānana a hoʻololi ʻia i keke kānana. Hoʻolako ʻia ka keke kānana hopena me ka mahu 0.3mpa a me ka wai wela 95 ℃ me ka lakio kaumaha o 10.0 i ka ʻāpana paʻa o ka HYDROXYpropyl methyl cellulose i holoi ʻia, a laila kānana ʻia ma o kahi kānana.
Hoʻolako ʻia ka wai wela ma o kahi pamu ma ke kaomi hoʻokuʻu ʻana o 0.2mpa. Ma hope o ka hoʻolako ʻia ʻana o ka wai wela, hoʻolako ʻia ka mahu 0.3mpa. A laila, ma hope o ka holoi ʻana, wehe ʻia nā huahana mai ka ʻili kānana e kahi mea ʻoki a hoʻokuʻu ʻia mai ka mīkini holoi. Hoʻomau ʻia nā ʻanuʻu mai ka hoʻolako ʻana i ka slurry a hiki i ka hoʻokuʻu ʻana i nā huahana i holoi ʻia. E like me ke ana ʻana me ka hoʻohana ʻana i ka hygrometer hoʻomaloʻo wela, ʻo ka nui o ka wai o ka huahana i holoi ʻia i hoʻokuʻu ʻia pēlā he 52.8%. Ua hoʻomaloʻo ʻia nā huahana i holoi ʻia i hoʻokuʻu ʻia mai ke kānana kaomi wili e kahi mea hoʻomaloʻo ea ma 80℃, a ua kuʻi ʻia i loko o ka wili Victory e loaʻa ai ka hydroxypropyl methyl cellulose.
2. Noi
HPMCHoʻohana ʻia ka huahana ma ke ʻano he mea hoʻomānoanoa, hoʻolaha, mea hoʻopaʻa, emulsifier a me ka mea hoʻopaʻa i ka ʻoihana lole. Hoʻohana nui ʻia hoʻi i ka resin synthetic, petrochemical, ceramic, pepa, ʻili, lāʻau lapaʻau, meaʻai, mea hoʻonani a me nā ʻoihana ʻē aʻe.
Ka manawa hoʻouna: ʻApelila-26-2024