Hydroxypropyl methyl cellulose HPMC, tseem hu ua hydroxypromellose, yog ib qho dawb rau dawb-dawb cellulose ether hmoov lossis granule uas muaj dej txias solubility thiab dej kub insolubility zoo ib yam li methyl cellulose. Hydroxypropyl pawg thiab methyl pawg yog ether bond thiab anhydrous glucose nplhaib ntawm cellulose ua ke, yog ib hom non-ionic cellulose sib xyaw ether. Nws yog ib qho semi-synthetic, inactive, viscoelastic polymer feem ntau siv ua lubricant hauv ophthalmology, lossis ua ib qho excipient lossis excipient hauv cov tshuaj noj.
1. Cov txheej txheem tsim khoom
Cov ntaub ntawv Kraft pulp nrog cov ntsiab lus αcellulose ntawm 97%, intrinsic viscosity ntawm 720mL / g thiab qhov nruab nrab fiber ntev ntawm 2.6 hli tau muab tso rau hauv 49% NaOH kua ntawm 40 ℃ rau 50 vib nas this. Tom qab ntawd cov ntaub ntawv raug extruded kom tshem tawm cov tshuaj NaOH ntau dhau kom tau txais alkali cellulose. Qhov hnyav piv ntawm (49% NaOH aqueous kua) rau (khoom khov ntawm cov ntaub ntawv) hauv kauj ruam impregnation yog 200. Qhov hnyav piv ntawm NaOH hauv alkali cellulose rau khoom khov hauv cov ntaub ntawv yog 1.49. Cov alkali cellulose tau txais (20kg) yog muab tso rau hauv lub tshuab hluav taws xob jacked nrog kev sib xyaw sab hauv, tom qab ntawd nqus tsev thiab purged nrog nitrogen kom tshem tawm cov pa oxygen ntawm lub tshuab hluav taws xob. Tom qab ntawd, qhov kub hauv lub tshuab hluav taws xob tau tswj hwm ntawm 60 ℃ thaum lub sijhawm sib xyaw sab hauv tau ua tiav.
Tom qab ntawd ntxiv 2.4kg dME thiab qhov kub hauv lub reactor tswj tau txog 60 ℃. Tom qab ntxiv dimethyl ether, ntxiv methylene chloride kom ua rau qhov sib piv ntawm methylene chloride rau NaOH hauv alkaline cellulose 1.3, ntxiv propylene oxide kom ua rau qhov sib piv ntawm propylene oxide rau khoom hauv pulp 1.97, thiab qhov kub hauv lub reactor tswj tau txij li 60 ℃ txog 80 ℃. Tom qab ntxiv chloromethane thiab propylene oxide, qhov kub hauv lub reactor tswj tau txij li 80 ℃ txog 90 ℃. Tsis tas li ntawd, qhov tshuaj tiv thaiv kav ntev li 20 feeb ntawm 90 ℃.
Cov roj ces raug ntws tawm ntawm lub reactor thiab cov hydroxypropyl methyl cellulose nyoos raug tshem tawm ntawm lub reactor. Qhov kub ntawm cov hydroxypropyl methyl cellulose nyoos yog 62 ℃. Ntsuas qhov sib sau ua ke 50% qhov loj me ntawm cov khoom me me hauv qhov hnyav sib sau ua ke raws li qhov sib piv ntawm cov hydroxypropyl methyl cellulose nyoos los ntawm qhov qhib ntawm tsib lub sieving, txhua tus muaj qhov qhib sib txawv.
Yog li ntawd, qhov nruab nrab ntawm cov khoom me me yog 6.2 hli. Cov hydroxypropyl methyl cellulose nyoos tau txais tau muab tso rau hauv lub tshuab kneader biaxial tas mus li (KRC kneader S1, L/D = 10.2, ntim sab hauv 0.12 L, tig ceev 150rpm) ntawm qhov ceev ntawm 10kg/teev, thiab tau txais cov hydroxypropyl methyl cellulose nyoos uas lwj lawm. Vim yog kev ntsuas zoo sib xws siv 5 lub ntxaij vab tshaus nrog qhov loj sib txawv, qhov nruab nrab ntawm cov khoom me me yog 1.4 hli. Ntxiv 80 ℃ dej kub rau cov hydroxypropyl methyl cellulose nyoos uas lwj lawm hauv lub tank nrog kev tswj qhov kub ntawm lub tsho. qhov ntau ntawm qhov hnyav piv ntawm cov hydroxypropyl methyl cellulose nyoos uas lwj lawm rau tag nrho cov slurry yog 0.1, thiab cov slurry tau txais. Cov slurry tau do ntawm qhov kub tas li ntawm 80 ℃ rau 60 feeb.
Tom qab ntawd, cov slurry raug muab rau qhov ceev tig ntawm 0.5 RPM thiab lub lim cua sov ua ntej (BHS Sonthofen cov khoom). Qhov kub ntawm grout yog 93 ℃. Siv lub twj tso kua mis los muab cov slurry, lub siab tso tawm ntawm lub twj tso kua mis yog 0.2mpa. Qhov loj me ntawm lub lim cua sov rotary yog 80μm, thiab thaj chaw lim yog 0.12m2. Cov slurry uas muab rau lub lim cua sov rotary raug lim los ntawm lub lim thiab hloov mus ua lub ncuav mog qab zib lim. Lub ncuav mog qab zib lim tau muab nrog 0.3mpa pa thiab 95 ℃ dej kub nrog qhov hnyav piv ntawm 10.0 rau cov khoom khov ntawm HYDROXYpropyl methyl cellulose ntxuav, uas tom qab ntawd raug lim los ntawm lub lim.
Cov dej kub raug muab los ntawm lub twj tso kua mis ntawm lub siab tso tawm ntawm 0.2mpa. Tom qab muab dej kub, cov pa dej 0.3mpa raug muab. Tom qab ntawd, tom qab ntxuav cov khoom raug tshem tawm ntawm qhov chaw lim dej los ntawm lub scraper thiab tso tawm ntawm lub tshuab ntxhua khaub ncaws. Cov kauj ruam los ntawm kev muab cov slurry mus rau kev tso tawm cov khoom ntxuav tau ua tiav tas li. Raws li ntsuas siv lub tshuab cua sov - ziab hygrometer, cov dej ntsiab lus ntawm cov khoom ntxuav uas tau tso tawm yog 52.8%. Cov khoom ntxuav uas tau tso tawm ntawm lub lim dej siab rotary tau ziab los ntawm lub tshuab ziab cua ntawm 80 ℃, thiab tsoo hauv lub tshuab Victory kom tau txais hydroxypropyl methyl cellulose.
2. Daim Ntawv Thov
HPMCCov khoom no siv ua thickener, dispersant, binder, emulsifier thiab stabilizer hauv kev lag luam textile. Kuj siv dav hauv cov khoom siv hluavtaws, petrochemical, ceramic, ntawv, tawv, tshuaj, khoom noj, tshuaj pleev ib ce thiab lwm yam lag luam.
Lub sijhawm tshaj tawm: Plaub Hlis-26-2024