I-Hydroxypropyl methyl cellulose HPMC, eyaziwa ngokuba yi-hydroxypromellose, yi-powder okanye i-granule ye-cellulose emhlophe ukuya kwemhlophe ene-cold water solubility kunye ne-hot water inselubility efana ne-methyl cellulose. Iqela le-hydroxypropyl kunye neqela le-methyl zi-ether bond kunye ne-anhydrous glucose ring ye-cellulose edibeneyo, luhlobo lwe-non-ionic cellulose mixed ether. Yi-semi-synthetic, i-intact, viscoelastic polymer esetyenziswa rhoqo njenge-lubricant kwi-ophthalmology, okanye njenge-excipient okanye i-excipient kumayeza omlomo.
1. Inkqubo yemveliso
I-pulp ye-Kraft enomxholo we-αcellulose oyi-97%, i-viscosity yangaphakathi ye-720mL /g kunye nobude obuphakathi befayibha eyi-2.6mm yacwiliswa kwisisombululo se-NaOH esingama-49% kwi-40℃ kangangemizuzwana engama-50. Emva koko i-pulp yakhutshwa ukuze kususwe isisombululo se-NaOH esingama-49% esingaphezulu ukuze kufunyanwe i-alkali cellulose. Umlinganiselo wobunzima be-(49% NaOH aqueous solution) ukuya kwi-(solid component ye-pulp) kwinyathelo lokufunxa yayiyi-200. Umlinganiselo wobunzima be-NaOH kwi-alkali cellulose ukuya kwi-solid kwi-pulp yi-1.49. I-alkali cellulose efunyenweyo ngaloo ndlela (20kg) ifakwa kwi-jacked pressure reactor ene-internal agitation, emva koko i-vacuum cleaner kwaye ihlanjululwe nge-nitrogen ukuze isuse ioksijini ngokwaneleyo kwi-reactor. Emva koko, ubushushu kwi-reactor balawulwa kwi-60℃ ngelixa kusenziwa i-internal stirging.
Emva koko kongezwa i-2.4kg dME kwaye ubushushu kwi-reactor bulawulwa ukuya kwi-60℃. Emva kokongezwa kwe-dimethyl ether, kongezwa i-methylene chloride ukwenza umlinganiselo we-molar we-methylene chloride ukuya kwi-NaOH kwi-alkaline cellulose 1.3, kongezwa i-propylene oxide ukwenza umlinganiselo wobunzima be-propylene oxide ukuya kwi-solid kwi-pulp 1.97, kwaye ubushushu kwi-reactor bulawulwa ukusuka kwi-60℃ ukuya kwi-80℃. Emva kokongeza i-chloromethane kunye ne-propylene oxide, ubushushu kwi-reactor bulawulwa ukusuka kwi-80℃ ukuya kwi-90℃. Ukongeza, impendulo yahlala imizuzu engama-20 kwi-90℃.
Emva koko igesi iyakhutshwa kwi-reactor kwaye i-crude hydroxypropyl methyl cellulose isuswe kwi-reactor. Ubushushu be-crude hydroxypropyl methyl cellulose yayiyi-62℃. Linganisa ubungakanani be-cumulative 50% particles kwi-cumulative weight based particle size distribution ngokusekelwe kumlinganiselo we-crude hydroxypropyl methyl cellulose kwiimbobo ze-five sieving, nganye inobukhulu obahlukileyo bokuvula.
Ngenxa yoko, ubungakanani obuqhelekileyo be-particle yamasuntswana arhabaxa yayiyi-6.2mm. I-crude hydroxypropyl methyl cellulose efunyenweyo yangeniswa kwi-continuous biaxial kneader (i-KRC kneader S1, L/D = 10.2, i-internal volume 0.12 L, i-rotation speed 150rpm) ngesantya se-10kg/hr, kwaye kwafunyanwa i-crude hydroxypropyl methyl cellulose ebolileyo. Ngenxa yokulinganisa okufanayo kusetyenziswa izikrini ezi-5 ezinobukhulu obahlukeneyo bokuvula, ubungakanani obuqhelekileyo be-particle yayiyi-1.4mm. Ukongeza amanzi ashushu angama-80℃ kwi-crude hydroxypropyl methyl cellulose ebolileyo etankini ngolawulo lobushushu bejacket. ubungakanani bomlinganiselo wobunzima be-crude hydroxypropyl methyl cellulose ebolileyo kwisixa siphela se-slurry yi-0.1, kwaye i-slurry ifunyenwe. I-slurry ivuselelwe kubushushu obungaguqukiyo be-80℃ imizuzu engama-60.
Emva koko, i-slurry inikwa isantya esijikelezayo se-0.5 RPM kunye nesihluzi soxinzelelo olujikelezayo esifudunyezwayo (iimveliso ze-BHS Sonthofen). Ubushushu be-grout yi-93℃. Sebenzisa ipompo ukubonelela nge-slurry, uxinzelelo lokukhupha ipompo yi-0.2mpa. Ubungakanani bokuvula kwesihluzi soxinzelelo olujikelezayo yi-80μm, kwaye indawo yesihluzi yi-0.12m2. I-slurry enikwa kwisihluzi soxinzelelo olujikelezayo ihluzwa ngesihluzi kwaye iguqulwe ibe yikhekhe lesihluzi. Ikhekhe lesihluzi eliphumayo linikwa umphunga we-0.3mpa kunye namanzi ashushu angama-95℃ anomlinganiselo wobunzima we-10.0 kwinxalenye eqinileyo ye-HYDROXYpropyl methyl cellulose ehlanjiweyo, emva koko ihluzwa ngesihluzi.
Amanzi ashushu anikezelwa ngempompo ngoxinzelelo lokukhupha oluyi-0.2mpa. Emva kokuba amanzi ashushu enikezelwe, kunikezelwa ngomphunga ongu-0.3mpa. Emva koko, emva kokuba iimveliso zokuhlamba zisuswa kumphezulu wesihluzo ngesikrwela kwaye zikhutshwe kumatshini wokuhlamba. Amanyathelo ukusuka ekunikezeni i-slurry ukuya ekukhupheni iimveliso ezihlanjiweyo enziwa rhoqo. Njengoko kulinganiswa kusetyenziswa i-hygrometer yokushisa-yokomisa, umxholo wamanzi wemveliso ehlanjiweyo ekhutshwe ngaloo ndlela yayiyi-52.8%. Iimveliso ezihlanjiweyo ezikhutshwe kwisihluzo soxinzelelo olujikelezayo zomiswa ngesixhobo sokomisa umoya kwi-80℃, zaza zatyunyuzwa kwi-Victory mill ukuze kufunyanwe i-hydroxypropyl methyl cellulose.
2. Isicelo
I-HPMCLe mveliso isetyenziswa njengesithambisi-manzi, isinyibilikisi-manzi, isihlanganisi-manzi, isinyibilikisi-manzi kunye nesiqinisi kwishishini lempahla. Ikwasetyenziswa kakhulu kwi-resin yokwenziwa, i-petrochemical, i-ceramic, iphepha, isikhumba, amayeza, ukutya, izinto zokuthambisa kunye neminye imimandla.
Ixesha leposi: Epreli-26-2024