Hydroxypropyl methyl cellulose HPMC, inozivikanwawo sehydroxypromellose, ipurasitiki chena kubva kuchena kuenda kuchena ye cellulose ether kana granule ine mvura inotonhora inonyunguduka uye mvura inopisa isinganyunguduke yakafanana nemethyl cellulose. Hydroxypropyl group ne methyl group i ether bond uye anhydrous glucose ring ye cellulose yakabatana, imhando ye non-ionic cellulose mixed ether. Ipolymer ye semi-synthetic, inactive, viscoelastic inowanzoshandiswa semafuta mu ophthalmology, kana se excipient kana excipient mumishonga inonwiwa.
1. Maitiro ekugadzira
Kraft pulp ine αcellulose ye97%, viscosity yemukati ye720mL /g uye avhareji yehurefu hwefiber ye2.6mm yakanyikwa mu49% NaOH solution pa40℃ kwemasekonzi makumi mashanu. Zvadaro pulp yakaburitswa kuti ibvise 49% NaOH solution yakawandisa kuti iwane alkali cellulose. Chiyero chehuremu hwe (49% NaOH aqueous solution) ku (solid component ye pulp) muchikamu chekuisa mu impregnation chaive 200. Chiyero chehuremu hweNaOH mu alkali cellulose kune solid mu pulp i1.49. Alkali cellulose yakawanikwa (20kg) inoiswa mu jacketed pressure reactor ine internal agitation, yozobviswa vacuum uye yocheneswa ne nitrogen kuti ibvise oxygen zvakakwana kubva mu reactor. Zvadaro, tembiricha mu reactor yakadzorwa pa60℃ uku internal stirging ichiitwa.
Zvadaro 2.4kg dME yakawedzerwa uye tembiricha mu reactor yakadzorwa kusvika 60℃. Mushure mekuwedzerwa dimethyl ether, methylene chloride yakawedzerwa kuti pave ne molar ratio yemethylene chloride kuNaOH mu alkaline cellulose 1.3, propylene oxide yakawedzerwa kuti pave ne weight ratio yepropylene oxide kune solid mu pulp 1.97, uye tembiricha mu reactor yakadzorwa kubva 60℃ kusvika 80℃. Mushure mekuwedzera chloromethane ne propylene oxide, tembiricha mu reactor yakadzorwa kubva 80℃ kusvika 90℃. Pamusoro pezvo, reaction yakatora maminetsi makumi maviri pa90℃.
Gasi rinozobuda mu reactor uye crude hydroxypropyl methyl cellulose inobviswa mu reactor. Tembiricha yecrude hydroxypropyl methyl cellulose yaive 62℃. Yera cumulative 50% particle size mukugoverwa kwe cumulative weight based particle size zvichibva pachiyero checrude hydroxypropyl methyl cellulose kuburikidza nemaburi e five sieving, imwe neimwe iine saizi yakasiyana yekuvhura.
Nekuda kweizvozvo, avhareji yehukuru hwezvimedu zve coarse particles yaive 6.2mm. Crude hydroxypropyl methyl cellulose yakawanikwa yakaiswa mu continuous biaxial kneader (KRC kneader S1, L/D = 10.2, internal volume 0.12 L, rotation speed 150rpm) nekumhanya kwe10kg/hr, uye decomposed crude hydroxypropyl methyl cellulose yakawanikwa. Nekuda kwekuyerwa kwakafanana uchishandisa ma screens mashanu ane saizi dzakasiyana dzekuvhura, avhareji yehukuru hwezvimedu yaive 1.4mm. Kuwedzera mvura inopisa ye80℃ kune decomposed crude hydroxypropyl methyl cellulose mutangi nekudzora tembiricha yejaketi. huwandu hwehuremu hwe decomposed crude hydroxypropyl methyl cellulose kune huwandu hwese hwe slurry i0.1, uye slurry inowanikwa. Slurry yakamutswa patembiricha isingachinji ye80℃ kwemaminitsi makumi matanhatu.
Zvadaro, slurry inopihwa kusvika pakumhanya kwe0.5 RPM uye firita rinotenderera rinopisa (BHS Sonthofen products). Tembiricha yegrout i93℃. Shandisa pombi kupa slurry, pressure yekuburitsa pombi i0.2mpa. Saizi yekuvhura kwefirita rinotenderera rinosvika 80μm, uye nzvimbo yefirita i0.12m2. Slurry inopihwa kufirita rinotenderera rinoseferwa kuburikidza nefirita uye rinoshandurwa kuita firita keke. Keke rinobuda rinopihwa 0.3mpa steam uye 95℃ hot water ine huremu hwe10.0 kune chikamu chakasimba cheHYDROXYpropyl methyl cellulose yakagezwa, iyo inozoseferwa kuburikidza nefirita.
Mvura inopisa inopihwa kuburikidza nepombi ine simba rekuburitsa mvura ye0.2mpa. Mushure mekunge mvura inopisa yapihwa, utsi hwe0.3mpa hunopihwa. Zvadaro, mushure mekunge zvinhu zvekusuka zvinobviswa pamusoro pefirita ne scraper zvoburitswa mumuchina wekusuka. Matanho kubva pakupa slurry kusvika pakuburitsa zvinhu zvakasukwa zvinoitwa nguva dzose. Sekuyerwa uchishandisa heat-drying hygrometer, huwandu hwemvura hwechinhu chakasukwa hwaive 52.8%. Zvinhu zvakasukwa zvakaburitswa kubva mu rotary pressure filter zvakaomeswa nemuchina wekuomesa mhepo pa80℃, zvopwanywa muVictory mill kuti zviwane hydroxypropyl methyl cellulose.
2.Kushandiswa
HPMCChigadzirwa ichi chinoshandiswa sechinosimbisa, chinoparadzira, chinosunga, chinosanganisa uye chinosimbisa muindasitiri yemachira. Chinoshandiswawo zvakanyanya mukugadzira resin, petrochemical, ceramic, bepa, dehwe, mishonga, chikafu, zvizoro nedzimwe nzvimbo.
Nguva yekutumira: Kubvumbi-26-2024