Ho teteana ha Hydroxypropyl methyl cellulose (HPMC) bakeng sa seaparo se phutholohileng?
– karabo: Kobo e nang le letlalo le lesesaane e lokile hangata HPMC 100000cps, e telele ho feta tlhoko ea seretse, e batla bokhoni ba ho e sebelisa ba 150000cps. Ho feta moo, HPMC ke karolo ea bohlokoa ka ho fetisisa ea ho boloka metsi, e lateloa ke ho teteana. Kobo e nang le letlalo le lesesaane, ha feela ho boloka metsi ho le molemo, ho teteana ho le tlase (7-80000), hoa khoneha hape, ehlile, ho teteana ho hoholo, ho teteana ha metsi ho molemo, ha ho teteana ho feta 100 sekete, ho teteana ha ho teteana ha metsi ha ho hoholo.
Matšoao a mantlha a tekheniki a hydroxypropyl methyl cellulose (HPMC) ke afe?
Karabo: Bongata ba Hydroxypropyl le ho teteana, basebelisi ba bangata ba tsotella matšoao ana a mabeli. Bongata ba Hydroxypropyl bo phahame, ho boloka metsi ka kakaretso ho molemo. Ho teteana, ho boloka metsi, kamano (empa e seng ho feletseng) le hona ho molemo, 'me ho teteana, seretse sa samente ho molemo ho sebelisa tse ling.
Hydroxypropyl methyl cellulose (HPMC) ke thepa efe e ka sehloohong e tala?
Karabo: hydroxypropyl methyl cellulose (HPMC) thepa e tala e ka sehloohong: k'hothone e hloekisitsoeng, chloromethane, propylene oxide, thepa e tala e meng, alkali ea matlapa, asiti, toluene, joala ba isopropyl le tse ling.
HPMC ka seaparo sa skim ha e sebelisoa, karolo e ka sehloohong ke efe, hore na ke lik'hemik'hale?
Karabo: HPMC ho Skim coat, ho tenya, metsi le kaho ea likarolo tse tharo. Ho tenya: cellulose e ka tenya ho fihlela e emisoa, e le hore tharollo e lule e lekana holimo le tlase e le karolo ea ho thibela phallo ea metsi. Ho boloka metsi: etsa hore Skim coat e ome butle, calcium e bohlooho e thusang ketsong ea karabelo ea metsi. Kaho: selulose ea cellulose, e ka etsa hore Skim coat e na le kaho e ntle. HPMC ha e kenelle liketsong life kapa life tsa lik'hemik'hale, empa e bapala karolo ea tšehetso feela. Skim coat le metsi, leboteng, ke karabelo ea lik'hemik'hale, ka lebaka la tlhahiso ea lintho tse ncha, lebota la Skim coat le theoha leboteng, le sila ho ba phofo, ebe le sebelisoa, ha le molemo, hobane le entse ntho e ncha (calcium carbonate). Likarolo tse ka sehloohong tsa phofo ea khalsiamo e putsoa ke: Ca(OH)2, CaO le motsoako o monyane oa CaCO3, CaO+H2O=Ca(OH)2 – Ca(OH)2+CO2=CaCO3↓+H2O khalsiamo e putsoa metsing le moeeng tlas'a ketso ea CO2, ho thehoa ha calcium carbonate, le metsi a HPMC feela, karabelo e thusang ea khalsiamo e putsoa e betere, ea eona ha ea ka ea kenya letsoho karabelong efe kapa efe.
HPMC ke ether ea cellulose e seng ea ionic, joale e seng ea ionic ke eng?
K: Ka kakaretso, li-non-ion ke lintho tse sa ioning ka metsing. Ionization ke ho arohana ha electrolyte ho ba li-ion tse tjhajileng tse tsamaeang ka bolokolohi ka har'a solvent e itseng, joalo ka metsi kapa joala. Mohlala, letsoai leo re le jang letsatsi le letsatsi - sodium chloride (NaCl) e qhibiliha ka metsing 'me ea ioning ho hlahisa li-ion tsa sodium tse tsamaeang ka bolokolohi (Na+) ka charge e ntle le li-ion tsa chloride (Cl) ka charge e mpe. Ke hore, HPMC ka metsing ha e arohane le li-ion tse tjhajileng, empa e teng e le limolek'hule.
Mocheso oa gelation oa hydroxypropyl methyl cellulose o amana le eng?
Karabo: Thempereichara ea gel ea HPMC e amana le litaba tsa methoxyl. Ha litaba tsa methoxyl li le tlase, mocheso oa gel o ba holimo.
Phofo ea seaparo se se nang mafura le HPMC ha ho na kamano?
Karabo: Phofo ea lerotholi la skim coat haholo-holo le boleng ba calcium ea molora li na le kamano e kholo haholo, 'me HPMC ha e na kamano e kholo haholo. Khalsiamo e tlase ea calcium e putsoa le karolo e sa lokelang ea CaO le Ca(OH)2 ka calcium e putsoa li tla baka ho oa ha phofo. Haeba ho na le kamano le HPMC, joale ho bolokoa ha metsi a fokolang a HPMC le hona ho tla baka tahlehelo ea phofo.
Phapang ke efe pakeng tsa hydroxypropyl methyl cellulose e qhibilihang ka metsing a batang le e qhibilihang ka ho chesang ea hydroxypropyl methyl cellulose ts'ebetsong ea tlhahiso?
– Karabo: Mofuta oa tharollo ea hang-hang ea metsi a batang a HPMC ke ka mor'a kalafo ea bokaholimo ba glyoxal, e kenngoa ka metsing a batang e hasanngoa kapele, empa ha e qhibilihe hantle, viscosity e ea phahama, ea qhibiliha. Mofuta o qhibilihang ka thermosol ha o so phekoloe bokaholimo ka glyoxal. Bongata ba glyoxal bo boholo, ho hasana ho potlakile, empa viscosity e lieha, bongata bo bonyenyane, ho fapana le hoo.
Ke eng e nkhang hamonate ka hydroxypropyl methyl cellulose (HPMC)?
– Karabo: HPMC e hlahisoang ka mokhoa oa ho qhibilihisa e entsoe ka toluene le isopropyl alcohol. Haeba ho hlatsoa ho se monate haholo, ho tla ba le tatso e setseng.
Tšebeliso e fapaneng, mokhoa oa ho khetha hydroxypropyl methyl cellulose (HPMC) e loketseng?
– karabo: teneha ka ho sebelisa phofo ea bana: tlhoko e tlase, viscosity 100000, ho lokile, ho bohlokoa ho sireletsa metsi hore a be haufi le eona. Ho sebelisa seretse: litlhoko tse phahameng, litlhoko tse phahameng tsa viscosity, 150000 hore e be betere. Ho sebelisa sekhomaretsi: tlhoko ea lihlahisoa tsa hang-hang, viscosity e phahameng.
Lebitso le leng la hydroxypropyl methyl cellulose ke lefe?
– KARABO: Hydroxypropyl MethylCellulose, E khutsufalitsoeng e le HPMC kapa MHPC, kapa Hydroxypropyl Methyl Cellulose; Cellulose hydroxypropyl methyl ether; Hypromellose, Cellulose, 2-hydroxypropyl methyl Cellulose ether.
HPMC ts'ebelisong ea seaparo se se nang letlalo, ke hobane'ng ha bubble ea seaparo se se nang letlalo e le teng?
Karabo: HPMC ka letlalo le teteaneng, ho teteana, metsi le kaho ea likarolo tse tharo. Ha e kenelle karabelong efe kapa efe. Lisosa tsa lipululana: 1, metsi a mangata haholo. 2, karolo e ka tlase ha e ome, e ka holimo ho lera la ho hohla, hape e bonolo ho e ntsha matheba.
Lebota la ka hare le la kantle. Foromo ea seaparo se se nang letlalo?
– karabo: lebota la kahare Kobo e phutholohileng: calcium 800KG calcium e putsoa 150KG (starch ether, botala bo hloekileng, peng runtu, citric acid, polyacrylamide e ka eketsoa ka nepo)
Lebota la kantle seaparo se se nang mafura: samente 350KG calcium 500KG lehlabathe la quartz 150KG phofo ea latex 8-12kg ether ea cellulose 3KG ether ea starch 0.5kg faeba ea lehong 2KG
Phapang ke efe pakeng tsa HPMC le MC?
– Karabo: MC ke methyl cellulose, e entsoeng ka cellulose ether ka letoto la dikarabelo tse nang le methane chloride e le moemedi ya etherifying ka mora hore k'hothone e hlwekisitsweng e phekolwe ka alkali. Ka kakaretso, tekanyo ya phetolo ke 1.6~2.0, mme ho qhibiliha ho fapana ho ya ka tekanyo ya phetolo. Ke ya nonionic cellulose ether.
(1) Ho boloka metsi ha methyl cellulose ho itshetlehile ka bongata ba yona ba ho eketsa, ho teteana, ho teteana ha dikarolwana le sekgahla sa ho qhalana. Ka kakaretso ho eketsa bongata bo boholo, ho teteana ho honyenyane, ho teteana, sekgahla sa ho teteana ha metsi se hodimo. Har'a tsona, bongata ba tlatsetso bo na le tshusumetso e kgolo hodima ho teteana ha metsi, mme ho teteana ha ho lekane le ho teteana ha metsi. Sekgahla sa ho qhaqha se itshetlehile haholo-holo ka tekanyo ya phetoho ya bokahodimo le ho teteana ha dikarolwana tsa cellulose. Ho di-ether tse mmalwa tsa cellulose tse ka hodimo, sekgahla sa ho teteana ha metsi sa methyl cellulose le hydroxypropyl methyl cellulose se hodimo.
(2) Methyl cellulose e qhibiliha metsing a batang, e leng ntho e thata ho e qhibilihisa metsing a chesang. Tharollo ea eona ea metsi e tsitsitse haholo ka har'a pH=3~12. E lumellana hantle le starch, gum ea guanidine le li-surfactants tse ngata. Gelation e etsahala ha mocheso o fihla mochesong oa gelation.
(3) Phetoho ea mocheso e tla ama ka botebo sekhahla sa ho boloka metsi sa methyl cellulose. Ka kakaretso, ha mocheso o phahame, ho boloka metsi ho mpefala. Haeba mocheso oa seretse o feta 40℃, ho boloka metsi ha methyl cellulose ho tla mpefala haholo, e leng se amang ka botebo ho hahuoa ha seretse.
(4) Methyl cellulose e na le tshusumetso e totobetseng hodima ho hahuwa le ho kgomarela ha seretse. “Ho kgomarela” mona ho bolela kgomarela e utlwiwang ke mosebetsi pakeng tsa sesebediswa le substrate ya lebota, e leng ho hanyetsa ho kgomarela ha seretse. Kgomarela e kgolo, kganyetso ya ho kgomarela ha seretse e kgolo, matla a hlokahalang ke basebetsi nakong ya tshebediso le ona a maholo, mme kaho ya seretse e fokola. Dihlahisweng tsa ether tsa cellulose, kgomarela ya methyl cellulose e maemong a itekanetseng.
HPMC hydroxypropyl methyl cellulose, e hloekisoa ka k'hothone kamora kalafo ea alkali, ka propylene oxide le chloromethane e le moemeli oa etherifying, ka letoto la liketso 'me e entsoe ka ether e tsoakiloeng ea cellulose e seng ea ionic. Tekanyo ea ho nkeloa sebaka ka kakaretso ke 1.2 ~ 2.0. Thepa ea eona e fapana ho latela karolo ea methoxy le hydroxypropyl.
(1) Hydroxypropyl methyl cellulose e qhibiliha habonolo metsing a batang, e leng ntho e thata ho e qhibilihisa metsing a chesang. Leha ho le jwalo, mocheso wa yona wa gelation metsing a chesang o phahame ho feta wa methyl cellulose. Ho qhibiliha ha methyl cellulose metsing a batang le hona ho ntlafetse haholo.
(2) Viscosity ea hydroxypropyl methyl cellulose e amana le boima ba eona ba limolek'hule, 'me ha boima ba limolek'hule bo le holimo, viscosity e ba holimo. Mocheso le oona o ama viscosity. Viscosity ea fokotseha ha mocheso o ntse o eketseha. Empa viscosity ea eona phello ea mocheso o phahameng e tlase ho feta ea methyl cellulose. Tharollo e tsitsitse ha e bolokoa mochesong oa kamore.
(3) Hydroxypropyl methyl cellulose e tsitsitse ho ea ho asiti le motheo, 'me tharollo ea eona ea metsi e tsitsitse haholo ho tloha ho pH=2 ~ 12. Caustic soda le metsi a lime ha li na phello e kholo litšobotsing tsa eona, empa alkali e ka potlakisa sekhahla sa ho qhibiliha ha eona le ho ntlafatsa viscosity. Hydroxypropyl methyl cellulose e tsitsitse ho ea ho letsoai le akaretsang, empa ha mahloriso a tharollo ea letsoai a le holimo, viscosity ea tharollo ea hydroxypropyl methyl cellulose e atisa ho eketseha.
(4) Ho boloka metsi ha hydroxypropyl methyl cellulose ho itshetlehile ka tekanyo le ho teteana ha yona, mme sekgahla sa ho boloka metsi sa hydroxypropyl methyl cellulose se hodimo ho feta sa methyl cellulose ka tekanyo e tshwanang.
(5) Hydroxypropyl methyl cellulose e ka kopanngoa le metsoako ea polymer e qhibilihang ka metsing hore e be tharollo e ts'oanang, e nang le viscosity e phahameng. Tse kang polyvinyl alcohol, starch ether, sekhomaretsi sa meroho le tse ling.
(6) Ho khomarela ha hydroxypropyl methyl cellulose kahong ea seretse ho phahame ho feta ha methyl cellulose.
(7) Hydroxypropyl methyl cellulose e na le khanyetso e betere ea lienzyme ho feta methyl cellulose, 'me monyetla oa ho senyeha ha lienzyme ea tharollo ea eona o tlase ho feta oa methyl cellulose.
Ke eng e lokelang ho elwa hloko ts'ebelisong e sebetsang mabapi le kamano pakeng tsa viscosity le mocheso oa HPMC?
Karabo: Viscosity ea HPMC e lekana ka tsela e fapaneng le mocheso, ke hore, viscosity ea eketseha ha mocheso o fokotseha. Ha re bua ka viscosity ea sehlahisoa, re bua ka viscosity ea 2% ea sehlahisoa metsing ka likhato tse 20 tsa Celsius.
Ha ho sebelisoa ka mokhoa o sebetsang, libakeng tse nang le phapang e kholo ea mocheso pakeng tsa lehlabula le mariha, ho lokela ho hlokomeloa hore ho khothaletsoa ho sebelisa viscosity e tlase mariha, e leng se thusang haholo kahong. Ho seng joalo, ha mocheso o le tlase, viscosity ea cellulose e tla eketseha, 'me ha e hohla, maikutlo a tla ba boima.
Viscosity e mahareng: 75000-100000 e sebelisoa haholo bakeng sa putty
Lebaka: Ho boloka metsi hantle
Viscosity e phahameng: HPMC 150000-200000 e sebelisoa haholo bakeng sa seretse sa polystyrene sa ho thibela li-particle le thepa ea phofo ea sekhomaretsi sa ho thibela li-beads.
Lebaka: ho teteana ho hoholo, seretse ha se bonolo ho se theola, phallo ea metsi e leketlile, e ntlafatsa kaho.
Empa ka kakaretso, ha viscosity e phahame, ho boloka metsi ho ba betere, kahoo lifeme tse ngata tsa seretse se omileng, ha ho nahanoa ka litšenyehelo, li sebelisa viscosity e mahareng ea HPMC cellulose (75000-100000) ho nkela cellulose e mahareng le e tlase ea HPMC (20000-40000) sebaka ho fokotsa bongata ba tlatsetso.
Nako ea poso: Pherekhong-10-2022