Mothusi oa Meriana
Hydroxypropyl methylcellulose (HPMC) e tšoeu kapa e le milky white, ha e na monko, ha e latsoehe, phofo ea fibrous kapa granule, tahlehelo ea boima ba 'mele ha e omisoa ha e fete 10%, e qhibiliha metsing a batang empa e se metsi a chesang, butle-butle metsing a chesang, ho ruruha, peptization le ho theha viscous colloidal solution, e fetohang tharollo ha e pholile, 'me e fetoha gel ha e futhumala.HPMC ha e qhibilihe ka har'a ethanol, chloroform le ether.E qhibiliha ka har'a motsoako o motsoako oa methanol le methyl chloride.E boetse e qhibiliha ka har'a motsoako o tsoakiloeng oa acetone, methyl chloride le isopropanol le metsoako e meng ea tlhaho.Tharollo ea eona ea metsi e ka mamella letsoai (tharollo ea eona ea colloidal ha e senngoe ke letsoai), 'me pH ea 1% ea tharollo ea metsi ke 6-8.Foromo ea molek'hule ea HPMC ke C8H15O8-( C10H18O6) -C815O, 'me boima ba molek'hule bo ka bang 86,000.
HPMC e na le ho qhibiliha ho hoholo ha metsi metsing a batang.E ka qhibiliha ka tharollo e hlakileng ka ho hlohlelletsa hanyenyane metsing a batang.Ho fapana le hoo, ha e le hantle ha e qhibilihe metsing a chesang a ka holimo ho 60 ℃ 'me e ka ruruha feela.Ke ether e seng ea ionic cellulose.Tharollo ea eona ha e na tefiso ea ionic, ha e sebelisane le letsoai la tšepe kapa metsoako ea ionic, 'me ha e sebetsane le lisebelisoa tse ling tse tala nakong ea ho lokisetsa;e na le thepa e matla e khahlanong le allergic, 'me ka ho eketseha ha tekanyo ea ho nkela sebaka mohahong oa limolek'hule, eona E hanyetsana le ho kula le ho tsitsisa haholoanyane;e boetse e na le inert metabolism.Joaloka motsoako oa meriana, ha e na metabolized kapa ho kenngoa.Ka hona, ha e fane ka lik'hilojule merianeng le lijong.Ha e na lik'halori tse tlase, ha e na letsoai, 'me ha e na letsoai ho bakuli ba nang le lefu la tsoekere.Lithethefatsi le lijo tse fapaneng li na le ts'ebetso e ikhethang;e batla e tsitsitse ho li-acids le alkalis, empa haeba boleng ba PH bo feta 2 ~ 11 mme bo angoa ke mocheso o phahameng kapa o na le nako e telele ea ho boloka, viscosity ea eona e tla fokotseha;tharollo ea eona ea metsi e ka fana ka ts'ebetso ea Surface, e bonts'a tsitsipano e leka-lekaneng holim'a metsi le tsitsipano ea sefahleho;e na le emulsification e sebetsang tsamaisong ea mekhahlelo e 'meli, e ka sebelisoa e le stabilizer e sebetsang hantle le colloid e sireletsang;tharollo ea eona ea metsi e na le thepa e babatsehang ea ho etsa filimi, ke letlapa le pilisi Ntho e ntle ea ho roala.Seaparo sa filimi se entsoeng ke sona se na le melemo ea ho se be le mebala le ho ba thata.Ho eketsa glycerin ho ka boela ha ntlafatsa polasetiki ea eona.
Lihlahisoa tsa QualiCell HPMC li ka ntlafala ka thepa e latelang ho Pharmaceutical Excipient:
HPMC ha e se e qhibiliha ka metsing, 'me e qhibiliha ka har'a mokelikeli, HPMC e etsa filimi e bonaletsang e nang le matla a phahameng a tsitsipano.
·E matlafatsa matla a tlamang.
·Hydrophilic matrix e sebelisitsoeng hammoho le HPMC hydrates ho etsa lera la gel, ho laola mokhoa oa ho lokolloa ha lithethefatsi.
| Kereiti ea khothaletso: | Kopa TDS |
| HPMC 60AX5 | tlanya mona |
| HPMC 60AX15 | tlanya mona |