IHydroxypropyl Methylcellulose (HPMC)iyi-nonionic cellulose ether enezakhiwo ezinhle zefilimu, ukunamathela, ukujiya nokulawulwa kokukhululwa, futhi isetshenziswa kabanzi embonini yezemithi. Njengomsizi wezokwelapha, i-AnxinCel®HPMC ingasetshenziswa kumaphilisi, amaphilisi, amalungiselelo okukhululwa okuqhubekayo, amalungiselelo e-ophthalmic kanye nezinhlelo zokulethwa kwezidakamizwa zezihloko.
1. Izakhiwo ze-Physicochemical ze-HPMC
I-HPMC i-semi-synthetic polymer material etholwe nge-methylating kanye ne-hydroxypropylating cellulose yemvelo, enokuncibilika okuhle kakhulu kwamanzi kanye nokuvumelana kwe-biocompatibility. Ukunyibilika kwayo akuthintwa kancane izinga lokushisa kanye nenani le-pH, futhi ingakhukhumala emanzini ukuze yakhe isixazululo se-viscous, esiza ukukhululwa okulawulwayo kwezidakamizwa. Ngokusho kwe-viscosity, i-HPMC ingahlukaniswa ngezigaba ezintathu: i-viscosity ephansi (5-100 mPa·s), i-viscosity ephakathi (100-4000 mPa·s) kanye ne-viscosity ephezulu (4000-100000 mPa·s), ezifanele izidingo ezahlukene zokulungiselela.
2. Ukusetshenziswa kwe-HPMC emalungiselelweni emithi
2.1 Isicelo kumaphilisi
I-HPMC ingasetshenziswa njengesibophezelo, i-disintegrant, i-coating material kanye nokukhishwa okulawulwayo kwempahla yamathambo kumathebulethi.
Isibopho:I-HPMC ingasetshenziswa njengesibophezelo kugranulation emanzi noma imbudumbudu eyomile ukuze kuthuthukiswe amandla ezinhlayiyana, ubulukhuni bethebhulethi kanye nokuzinza kwemishini yezidakamizwa.
I-Disintegrant:I-HPMC ene-viscosity ephansi ingasetshenziswa njenge-disintegrant ukukhuthaza ukuhlakazeka kwethebhulethi futhi kukhuphule izinga lokuqedwa kwezidakamizwa ngemva kokuvuvukala ngenxa yokumuncwa kwamanzi.
Izinto zokumboza:I-HPMC ingenye yezinto eziyinhloko zokugqoka ithebhulethi, engathuthukisa ukubukeka kwezidakamizwa, ivale ukunambitheka okubi kwezidakamizwa, futhi ingasetshenziswa ekuhlanganiseni kwe-enteric noma ifilimu ehlanganiswe nama-plasticizers.
Izinto ezikhishwayo ezilawulwayo: I-HPMC ene-viscosity ephezulu ingasetshenziswa njengohlaka lwamathambo ukuze kubambezeleke ukukhishwa kwezidakamizwa futhi kuzuzwe ukukhululwa okuqhubekayo noma okulawulwayo. Isibonelo, i-HPMC K4M, HPMC K15M kanye ne-HPMC K100M zivame ukusetshenziselwa ukulungisa amaphilisi okukhishwa okulawulwayo.
2.2 Ukusetshenziswa emalungiselelweni we-capsule
I-HPMC ingasetshenziselwa ukukhiqiza amaphilisi angenalutho athathwe esitshalweni ukuze athathele indawo yamakhepsuli e-gelatin, alungele abantu abadla imifino kanye nabantu abangazwani namakhepsuli athathwe ezilwaneni. Ngaphezu kwalokho, i-HPMC ingasetshenziselwa ukugcwalisa uketshezi noma amaphilisi e-semisolid ukuze kuthuthukiswe ukuzinza kanye nezici zokukhululwa kwezidakamizwa.
2.3 Ukufaka isicelo elungiselelweni le-ophthalmic
I-HPMC, njengengxenye eyinhloko yezinyembezi zokwenziwa, ingakhuphula i-viscosity yamaconsi iso, yandise isikhathi sokuhlala kwezidakamizwa endaweni ye-ocular, futhi ithuthukise i-bioavailability. Ngaphezu kwalokho, i-HPMC ingase futhi isetshenziselwe ukulungisa amajeli wamehlo, amafilimu wamehlo, njll., ukuthuthukisa umphumela wokukhululwa okuqhubekayo wezidakamizwa zamehlo.
2.4 Ukufaka isicelo emalungiselelweni okulethwa kwezidakamizwa
I-AnxinCel®HPMC inezinto ezinhle zokwenza ifilimu kanye nokuvumelana kwe-biocompatibility, futhi ingasetshenziswa ukulungisa amapheshana e-transdermal, amajeli kanye nokhilimu. Isibonelo, ezinhlelweni zokulethwa kwezidakamizwa eziguquguqukayo, i-HPMC ingasetshenziswa njengento ye-matrix ukuze kukhuliswe izinga lokungena emthini futhi andise ubude besikhathi sokusebenza.
2.5 Ukufakwa kuketshezi lomlomo nokumiswa
I-HPMC ingasetshenziswa njenge-thickener kanye ne-stabilizer ukuthuthukisa izakhiwo ze-rheological zoketshezi lomlomo nokumiswa, ukuvimbela izinhlayiya eziqinile ekuxazululeni, futhi kuthuthukiswe ukufana nokuzinza kwezidakamizwa.
2.6 Ukusebenzisa amalungiselelo okuhogela
I-HPMC ingasetshenziswa njengesithwali se-powder inhalers (DPIs) eyomile ukuze kuthuthukiswe uketshezi kanye nokuhlakazeka kwezidakamizwa, ukwandisa izinga lokubeka amaphaphu ezidakamizwa, futhi ngaleyo ndlela kuthuthukise umphumela wokwelapha.
3. Izinzuzo ze-HPMC kumalungiselelo okukhishwa okuqhubekayo
I-HPMC inezici ezilandelayo njenge-excipient-release-release:
Ukuncibilika kahle kwamanzi:Ingakhukhumala ngokushesha emanzini ukuze yakhe umgoqo wejeli futhi ilawule izinga lokukhululwa kwezidakamizwa.
I-biocompatibility enhle:engenabuthi futhi engacasuli, ayimuncwa umzimba womuntu, futhi inendlela ecacile ye-metabolic.
Ukuzivumelanisa nezimo okuqinile:Ifanele izinhlobo ezahlukene zezidakamizwa, kuhlanganise nezidakamizwa ezincibilikayo emanzini kanye ne-hydrophobic.
Inqubo elula:Ifanele izinqubo ezihlukahlukene zokulungiselela ezifana nethebhulethi eqondile kanye ne-granulation emanzi.
Njengomsizi obalulekile wemithi,I-HPMCisetshenziswa kabanzi emikhakheni eminingi efana namathebulethi, amaphilisi, amalungiselelo e-ophthalmic, amalungiselelo e-topical, njll., ikakhulukazi emalungiselelweni okukhishwa okuqhubekayo. Ngokuzayo, ngokuthuthukiswa okuqhubekayo kobuchwepheshe bokulungiselela imithi, ububanzi bokufaka isicelo be-AnxinCel®HPMC buzophinde bunwetshwe, kuhlinzekwe imboni yezokwelapha ngezinketho ezisebenza kahle neziphephile zokuthola usizo.
Isikhathi sokuthumela: Feb-08-2025