Ukusetyenziswa kweHydroxypropyl Methylcellulose (HPMC) njenge-Excipient yeMithi kumaLungiselelo

1. Iimpawu ze-HPMC ze-physicochemical

I-HPMC yinto yepolymer eyenziwe ngokwe-semi-synthetic efunyenwe nge-methylating kunye ne-hydroxypropylating natural cellulose, enobunyibiliko bamanzi obuhle kakhulu kunye nokuhambelana kwezinto eziphilayo. Ukunyibilika kwayo akuchaphazeleki kakhulu bubushushu kunye nexabiso le-pH, kwaye inokuvuvukala emanzini ukuze yenze isisombululo esiqinileyo, esinceda ukukhutshwa kwamayeza okulawulwayo. Ngokwe-viscosity, i-HPMC inokwahlulwa ibe ziindidi ezintathu: i-viscosity ephantsi (5-100 mPa·s), i-viscosity ephakathi (100-4000 mPa·s) kunye ne-viscosity ephezulu (4000-100000 mPa·s), ezifanelekileyo kwiimfuno ezahlukeneyo zokulungiselela.

2. Ukusetyenziswa kwe-HPMC kumayeza

2.1 Ukusetyenziswa kwiithebhulethi
I-HPMC ingasetyenziswa njengesixhobo sokubopha, ukuqhekeka, izinto zokugquma kunye nezinto zomthambo ezikhutshwa ngokulawulwayo kwiipilisi.
Isibopheleli:I-HPMC ingasetyenziswa njengesihlanganisi kwi-granulation emanzi okanye kwi-granulation eyomileyo ukuphucula amandla eenxalenye, ubulukhuni bethebhulethi kunye nokuzinza kwamayeza ngoomatshini.
Ukwahlukana:I-HPMC engaphantsi kokuqina ingasetyenziswa njengesixhobo sokunyibilikisa iipilisi ukukhuthaza ukubola kwazo nokunyusa izinga lokunyibilikisa amayeza emva kokudumba ngenxa yokufunxwa ngamanzi.
Izinto zokwaleka:I-HPMC yenye yezona zinto ziphambili zokugquma iipilisi, ezinokuphucula inkangeleko yamayeza, zigqume incasa embi yamayeza, kwaye zingasetyenziswa ekugqumeni iipleyiti okanye ekugqumeni iifilimu ngeeplastiki.
Izinto ezikhutshwa ngokulawulwayo: I-HPMC enobukrakra obuphezulu ingasetyenziswa njengezinto ezisisiseko zokulibazisa ukukhululwa kwamayeza kunye nokufezekisa ukukhululwa okuqhubekekayo okanye okulawulwayo. Umzekelo, i-HPMC K4M, i-HPMC K15M kunye ne-HPMC K100M zihlala zisetyenziselwa ukulungiselela iipilisi ezikhutshwa ngokulawulwayo.

2.2 Ukusetyenziswa kumalungiselelo eekhaphu
I-HPMC ingasetyenziselwa ukuvelisa iikhaphu ezingenanto ezithathwe kwizityalo ukuze zithathe indawo yeekhaphu zegelatin, ezifanelekileyo kubantu abatya imifuno kunye nabantu abane-aleji kwiikhaphu ezivela kwizilwanyana. Ukongeza, i-HPMC ingasetyenziselwa ukuzalisa iikhaphu ezingamanzi okanye eziqinileyo ukuphucula uzinzo kunye neempawu zokukhululwa kwamayeza.

2.3 Ukusetyenziswa kulungiselelo lwamehlo
I-HPMC, njengeyona nto iphambili kwiinyembezi zokwenziwa, inokunyusa ukuxinana kwamathontsi eliso, yandise ixesha lokuhlala kwamayeza kumphezulu weliso, kwaye iphucule ukufumaneka kwawo. Ukongeza, i-HPMC ingasetyenziselwa ukulungiselela iijeli zamehlo, iifilimu zamehlo, njl.njl., ukuphucula isiphumo sokukhululwa okuqhubekayo kwamayeza eliso.

2.4 Ukusetyenziswa kumalungiselelo okuhambisa amayeza angaphandle
I-AnxinCel®HPMC ineempawu ezilungileyo zokwenza ifilimu kunye nokuhambelana kwezinto eziphilayo, kwaye ingasetyenziselwa ukulungisa amabala e-transdermal, iijeli kunye neekhrimu. Umzekelo, kwiinkqubo zokuhambisa amayeza e-transdermal, i-HPMC ingasetyenziswa njengesixhobo se-matrix ukwandisa izinga lokungena kwamayeza kunye nokwandisa ixesha lokusebenza.