IHydroxypropyl Methylcellulose (HPMC)i-ether ye-cellulose ye-nonionic enefilimu efanelekileyo yokwenza ifilimu, i-adhesion, i-thiening kunye ne-controlled release release properties, kwaye isetyenziswa ngokubanzi kumashishini amayeza. Njengomxhasi wamachiza, i-AnxinCel®HPMC ingasetyenziswa kwiipilisi, ii-capsules, amalungiselelo okukhululwa okuqhubekayo, amalungiselelo e-ophthalmic kunye neenkqubo zokuhanjiswa kweziyobisi.
1. Iimpawu zePhysicochemical ze-HPMC
I-HPMC yimathiriyeli ye-semi-synthetic polymer efunyenwe nge-methylating kunye ne-hydroxypropylating cellulose yendalo, kunye nokunyibilika okugqwesileyo kwamanzi kunye ne-biocompatibility. Ukunyibilika kwayo akuchatshazelwa kancinci ngubushushu kunye nexabiso le-pH, kwaye inokudumba emanzini ukwenza isisombululo se-viscous, esinceda ukukhutshwa okulawulwayo kwamachiza. Ngokutsho kwe-viscosity, i-HPMC inokwahlulwa ibe ngamacandelo amathathu: i-viscosity ephantsi (5-100 mPa · s), i-viscosity ephakathi (100-4000 mPa · s) kunye ne-viscosity ephezulu (4000-100000 mPa · s), ezifanelekileyo kwiimfuno ezahlukeneyo zokulungiselela.
2. Ukusetyenziswa kwe-HPMC kumalungiselelo amayeza
2.1 Ukusetyenziswa kwiipilisi
I-HPMC ingasetyenziswa njenge-binder, i-disintegrant, i-coating material kunye ne-controlled-release skeleton material in tablets.
Isibophelelo:I-HPMC ingasetyenziswa njengesibophelelo kwigranulation emanzi okanye igranulation eyomileyo ukuphucula amandla amasuntswana, ubulukhuni bethebhulethi kunye nokuzinza koomatshini bamachiza.
Disintegrant:I-HPMC ene-viscosity ephantsi ingasetyenziswa njenge-disintegrant ukukhuthaza ukuchithwa kwethebhulethi kunye nokunyusa izinga lokuchithwa kweziyobisi emva kokudumba ngenxa yokufunxa kwamanzi.
Izinto zokugquma:I-HPMC yenye yezinto eziphambili zokugquma ithebhulethi, enokuphucula imbonakalo yamachiza, igqume incasa embi yeziyobisi, kwaye ingasetyenziselwa ukugquma kwe-enteric okanye ifilimu yokugquma ngeplastiki.
Izinto ezikhutshwayo ezilawulwayo: I-HPMC ye-viscosity ephezulu ingasetyenziselwa njengesixhobo samathambo ukulibazisa ukukhutshwa kweziyobisi kunye nokufezekisa ukukhululwa okuzinzileyo okanye okulawulwayo. Umzekelo, i-HPMC K4M, HPMC K15M kunye ne-HPMC K100M zihlala zisetyenziselwa ukulungiselela iipilisi ezilawulwayo ezikhutshwayo.
2.2 Ukusetyenziswa kumalungiselelo e-capsule
I-HPMC ingasetyenziselwa ukuvelisa ii-capsules ezingenanto eziphuma kwisityalo endaweni ye-gelatin capsules, ezilungele abantu abatya imifuno kunye nabantu abangadibaniyo ne-capsules ephuma kwizilwanyana. Ukongeza, i-HPMC ingasetyenziselwa ukugcwalisa ulwelo okanye i-capsules ye-semisolid ukuphucula uzinzo kunye nokukhululwa kweempawu zamachiza.
2.3 Ukusetyenziswa kumalungiselelo e-ophthalmic
I-HPMC, njengenxalenye ephambili yeenyembezi ezenziweyo, inokunyusa i-viscosity yamaconsi esweni, ukwandisa ixesha lokuhlala kweziyobisi kwindawo ye-ocular, kunye nokuphucula i-bioavailability. Ukongeza, i-HPMC ingasetyenziselwa ukulungisa iijeli zamehlo, iifilimu zamehlo, njl., Ukuphucula umphumo oqhubekayo wokukhululwa kweziyobisi zamehlo.
2.4 Ukusetyenziswa kumalungiselelo okuhanjiswa kweziyobisi kwizihloko
I-AnxinCel®HPMC ineempawu ezilungileyo zokwenza ifilimu kunye ne-biocompatibility, kwaye ingasetyenziselwa ukulungisa ama-patches e-transdermal, i-gel kunye ne-creams. Umzekelo, kwiinkqubo zokuhanjiswa kweziyobisi eziguquguqukayo, i-HPMC ingasetyenziswa njengesixhobo se-matrix ukunyusa izinga lokungena kwechiza kunye nokwandisa ixesha lesenzo.
2.5 Ukusetyenziswa kulwelo lomlomo kunye nokunqunyanyiswa
I-HPMC ingasetyenziswa njenge-thickener kunye nokuzinzisa ukuphucula iimpawu ze-rheological zolwelo lomlomo kunye nokunqunyanyiswa, ukuthintela amasuntswana aqinileyo ekuzinzeni, kunye nokuphucula ukufana kunye nokuzinza kweziyobisi.
2.6 Ukusetyenziswa kumalungiselelo okuphefumla
I-HPMC ingasetyenziselwa njengomphathi we-powder inhalers (DPIs) eyomileyo ukuze kuphuculwe i-fluidity kunye ne-dispersibility yamachiza, ukwandisa izinga lokubeka imiphunga yeziyobisi, kwaye ngaloo ndlela kuphuculwe umphumo wonyango.
3. Izinto eziluncedo ze-HPMC kumalungiselelo okukhutshwa okuzinzileyo
I-HPMC inezi mpawu zilandelayo njenge-excipient-release excipient:
Ukunyibilika kakuhle kwamanzi:Inokudumba ngokukhawuleza emanzini ukwenza umqobo wejeli kwaye ilawule izinga lokukhutshwa kwechiza.
Ukuhambelana kakuhle kwebhayoloji:i-non-toxic and non-arriting, engafuntshwanga ngumzimba womntu, kwaye inendlela ecacileyo ye-metabolic.
Ukuziqhelanisa ngamandla:Ifanelekile kwiindidi ezahlukeneyo zamachiza, kubandakanywa iziyobisi ezinyibilikayo emanzini kunye ne-hydrophobic.
Inkqubo elula:Ifanelekile kwiinkqubo ezahlukeneyo zokulungiselela ezifana nethebhulethi ngokuthe ngqo kunye ne-granulation emanzi.
Njengomncedi obalulekileyo kumayeza,HPMCisetyenziswa ngokubanzi kwiinkalo ezininzi ezifana neepilisi, ii-capsules, amalungiselelo e-ophthalmic, amalungiselelo e-topical, njl., ngakumbi kumalungiselelo okukhululwa okuqhubekayo. Kwixesha elizayo, ngophuhliso oluqhubekayo lweteknoloji yokulungiselela amayeza, umda wesicelo se-AnxinCel®HPMC uya kwandiswa ngakumbi, ukubonelela imboni yamachiza ngeendlela ezisebenzayo nezikhuselekileyo zokuncedisa.
Ixesha lokuposa: Feb-08-2025