Tšebeliso ea Hydroxypropyl Methylcellulose (HPMC) e le Mothusi oa Meriana Litokisetsong.

1. Physicochemical properties of HPMC

HPMC ke semi-synthetic polymer material e fumanoang ka methylating le hydroxypropylating cellulose ea tlhaho, e nang le metsi a mangata haholo le ho lumellana ha lintho. Ho qhibiliha ha eona ha ho amehe haholo ke mocheso le pH ea boleng, 'me e ka ruruha ka metsing ho etsa tharollo ea viscous, e thusang ho lokolloa ha lithethefatsi ho laoloang. Ho ea ka viscosity, HPMC e ka aroloa ka mekhahlelo e meraro: viscosity e tlaase (5-100 mPa·s), viscosity e bohareng (100-4000 mPa · s) le viscosity e phahameng (4000-100000 mPa·s), e loketseng litlhoko tse fapaneng tsa ho itokisa.

2. Tšebeliso ea HPMC litokisetsong tsa meriana

2.1 Tšebeliso ea matlapa
HPMC e ka sebelisoa e le se tlamang, se senyang, se koahelang, le lisebelisoa tsa marapo tse laoloang matlapeng.
Binder:HPMC e ka sebelisoa e le se tlamang ka granulation e metsi kapa granulation e omeletseng ho ntlafatsa matla a likaroloana, ho thatafala ha letlapa le botsitso ba mochini oa lithethefatsi.
Disintegrant:Low-viscosity HPMC e ka sebelisoa e le disintegrant ho khothalletsa ho arohana ha letlapa le ho eketsa sekhahla sa ho qhibiliha ha lithethefatsi ka mor'a ho ruruha ka lebaka la ho monya metsi.
Lisebelisoa tsa ho roala:HPMC ke e 'ngoe ea lisebelisoa tse ka sehloohong tsa ho roala letlapa, tse ka ntlafatsang ponahalo ea lithethefatsi, tsa koahela tatso e mpe ea lithethefatsi,' me li ka sebelisoa ka ho roala enteric kapa filimi e nang le li-plasticizers.
Lisebelisoa tse laoloang: HPMC e nang le viscosity e phahameng e ka sebelisoa e le lisebelisoa tsa skeleton ho lieha ho lokolloa ha lithethefatsi le ho finyella tokollo e tsitsitseng kapa e laoloang. Mohlala, HPMC K4M, HPMC K15M le HPMC K100M hangata li sebelisoa ho lokisa matlapa a lokolotsoeng a laoloang.

2.2 Kopo ka litokisetso tsa capsule
HPMC e ka sebelisoa ho hlahisa li-capsules tse nang le sekoti tse nkiloeng ke limela ho nka sebaka sa li-gelatin capsules, tse loketseng batho ba jang meroho le batho ba sa lumellaneng le li-capsules tse nkiloeng ke liphoofolo. Ntle le moo, HPMC e ka sebelisoa ho tlatsa li-capsules tsa metsi kapa tsa semisolid ho ntlafatsa botsitso le litšobotsi tsa tokollo ea lithethefatsi.

2.3 Kopo ka litokisetso tsa mahlo
HPMC, e le karolo e ka sehloohong ea meokho ea maiketsetso, e ka eketsa viscosity ea marotholi a mahlo, ho lelefatsa nako ea ho lula ha lithethefatsi sebakeng sa mahlo, le ho ntlafatsa bioavailability. Ho feta moo, HPMC e ka boela ea sebelisoa ho lokisa li-gel tsa mahlo, lifilimi tsa mahlo, joalo-joalo, ho ntlafatsa phello e tsitsitseng ea lithethefatsi tsa mahlo.

2.4 Kopo litokisetsong tsa ho fana ka lithethefatsi tse ka sehloohong
AnxinCel®HPMC e na le thepa e ntle ea ho etsa lifilimi le biocompatibility, 'me e ka sebelisoa ho lokisa li-patches tsa transdermal, li-gel le litlolo. Mohlala, lits'ebetsong tsa phepelo ea lithethefatsi tsa transdermal, HPMC e ka sebelisoa e le lisebelisoa tsa matrix ho eketsa sekhahla sa ho kenella ha lithethefatsi le ho lelefatsa nako ea ts'ebetso.