Hydroxypropyl Methylcellulose (HPMC)is nonionic cellulose ether ine yakanaka film-forming, adhesion, thickening and controlled release properties, uye inoshandiswa zvakanyanya muindasitiri yemishonga. Semubatsiri wemishonga, AnxinCel®HPMC inogona kushandiswa mumapiritsi, capsules, gadziriro dzinogara dziripo, gadziriro dzemaziso uye masisitimu ekutumira zvinodhaka.
1. Physicochemical properties yeHPMC
HPMC is a semi-synthetic polymer material inowanikwa nemethylating uye hydroxypropylating natural cellulose, ine yakanakisa kunyungudika kwemvura uye biocompatibility. Solubility yayo haina kukanganiswa nekupisa uye pH kukosha, uye inogona kuzvimba mumvura kuti iite viscous solution, iyo inobatsira kudzora kuburitswa kwezvinodhaka. Zvinoenderana neiyo viscosity, HPMC inogona kukamurwa kuita zvikamu zvitatu: yakaderera viscosity (5-100 mPa · s), yepakati viscosity (100-4000 mPa · s) uye yakakwirira viscosity (4000-100000 mPa · s), iyo inokodzera zvakasiyana kugadzirira zvinodiwa.
2. Kushandiswa kweHPMC mukugadzirira kwemishonga
2.1 Kushandiswa mumahwendefa
HPMC inogona kushandiswa sebhainda, disintegrant, coating material uye inodzorwa-kuburitsa skeleton zvinhu mumapiritsi.
Binder:HPMC inogona kushandiswa sebhainda mukunyorova granulation kana yakaoma granulation kuvandudza particle simba, piritsi kuoma uye mechanical kugadzikana kwemishonga.
Disintegrant:Low-viscosity HPMC inogona kushandiswa se disintegrant kukurudzira kupatsanurwa kwehwendefa uye kuwedzera kuparara kwezvinodhaka mushure mekuzvimba nekuda kwekutorwa kwemvura.
Coating material:HPMC ndechimwe chezvinhu zvakakosha zvekuputira piritsi, izvo zvinogona kuvandudza kutaridzika kwezvinodhaka, kuvhara kuravira kwakashata kwemishonga, uye inogona kushandiswa mukuputira enteric kana kupfekedza firimu neplasticizers.
Kudzorwa-kuburitsa zvinhu: Yakakwira-viscosity HPMC inogona kushandiswa senge skeleton zvinhu kunonoka kuburitswa kwezvinodhaka uye kuwana kwakasimba kana kudzora kuburitswa. Semuenzaniso, HPMC K4M, HPMC K15M uye HPMC K100M inowanzoshandiswa kugadzira mahwendefa anodzorwa-anoburitswa.
2.2 Kushandiswa mukugadzirira capsule
HPMC inogona kushandiswa kugadzira chirimwa-chinotorwa hollow capsules kutsiva gelatin capsules, iyo yakakodzera kune vanodya miriwo uye vanhu vasingawirirani nemhuka-yakatorwa makapulisi. Uye zvakare, HPMC inogona kushandiswa kuzadza mvura kana semisolid capsules kuvandudza kugadzikana uye kuburitsa maitiro emishonga.
2.3 Kushandiswa mukugadzirira kwemaziso
HPMC, sechikamu chikuru chemisodzi yekugadzira, inogona kuwedzera viscosity yemadonhwe eziso, kurebesa nguva yekugara kwemishonga pameso, uye kuvandudza bioavailability. Uye zvakare, HPMC inogona zvakare kushandiswa kugadzira gel dzemaziso, mafirimu emeso, nezvimwewo, kuvandudza iyo inoenderera yekuburitsa mhedzisiro yemishonga yemaziso.
2.4 Kushandiswa kwegadziriro yekuendesa zvinodhaka
AnxinCel®HPMC ine yakanaka yekugadzira firimu zvinhu uye biocompatibility, uye inogona kushandiswa kugadzira transdermal zvigamba, gels uye makirimu. Semuenzaniso, mune transdermal drug delivery systems, HPMC inogona kushandiswa sematrix zvinhu kuwedzera chiyero chekupinda kwezvinodhaka uye kurebesa nguva yekuita.
2.5 Kushandiswa mumvura yemuromo uye kumiswa
HPMC inogona kushandiswa seyakakora uye kudzikamisa kuvandudza rheological zvimiro zvemukanwa mvura uye kuturika, kudzivirira zvimedu zvakasimba kubva pakugadzirisa, uye kuvandudza kufanana uye kugadzikana kwezvinodhaka.
2.6 Kushandisa mukugadzirira kwekufema
HPMC inogona kushandiswa semutakuri wehupfu yakaoma inhalers (DPIs) kuvandudza fluidity uye dispersibility yemishonga, kuwedzera mapapu deposition rate yemishonga, uye nokudaro kuwedzera maitiro ekurapa.
3. Zvakanakira zveHPMC mukugadzirira-kuburitswa kwakasimba
HPMC ine anotevera maitiro seanogara-kuburitswa excipient:
Kunyungudika kwemvura kwakanaka:Inogona kukurumidza kuzvimba mumvura kuumba gel barriers uye kugadzirisa chiyero chekusunungurwa kwemishonga.
Zvakanaka biocompatibility:isina-chepfu uye isingatsamwire, isingabatiki nemuviri wemunhu, uye ine nzira yakajeka yemetabolism.
Kuchinja kwakasimba:Inokodzera mhando dzakasiyana dzemishonga, kusanganisira mvura-soluble uye hydrophobic mishonga.
Maitiro akareruka:Inokodzera maitiro akasiyana-siyana ekugadzirira akadai seyakananga tableting uye wet granulation.
Sechinhu chakakosha chemishonga chinobatsira,HPMCinoshandiswa zvakanyanya muminda yakawanda yakadai semapiritsi, capsules, ophthalmic kugadzirira, kugadzirira kwepamusoro, nezvimwewo, kunyanya mukugadzirisa-kusunungurwa kwekugadzirira. Mune ramangwana, nekuenderera mberi kwekuvandudza tekinoroji yekugadzira mishonga, chiyero chekushandisa cheAnxinCel®HPMC chichawedzerwa, zvichipa indasitiri yemishonga sarudzo dzakanyanya kushanda uye dzakachengeteka.
Nguva yekutumira: Feb-08-2025