Hydroxypropyl Methylcellulose (HPMC)ndi nonionic cellulose ether yokhala ndi mapangidwe abwino a filimu, kumamatira, kukhuthala ndi kuwongolera kumasulidwa, ndipo amagwiritsidwa ntchito kwambiri m'makampani opanga mankhwala. Monga chithandizo chamankhwala, AnxinCel®HPMC ikhoza kugwiritsidwa ntchito pamapiritsi, makapisozi, kukonzekera kosalekeza, kukonzekera maso ndi machitidwe operekera mankhwala apakhungu.
1. Physicochemical katundu wa HPMC
HPMC ndi semi-synthetic polima zakuthupi zomwe zimapezedwa ndi methylating ndi hydroxypropylating cellulose zachilengedwe, zosungunuka bwino kwambiri m'madzi komanso kuyanjana kwachilengedwe. Kusungunuka kwake sikukhudzidwa kwambiri ndi kutentha ndi pH mtengo, ndipo kumatha kutupa m'madzi kuti apange yankho la viscous, lomwe limathandizira kutulutsidwa kwa mankhwala. Malinga ndi mamasukidwe akayendedwe, HPMC akhoza kugawidwa m'magulu atatu: otsika mamasukidwe akayendedwe (5-100 mPa · s), sing'anga mamasukidwe akayendedwe (100-4000 mPa · s) ndi mkulu mamasukidwe akayendedwe (4000-100000 mPa · s), amene ali oyenera zofunika zosiyanasiyana kukonzekera.
2. Kugwiritsa ntchito HPMC pokonzekera mankhwala
2.1 Kugwiritsa ntchito pamapiritsi
HPMC angagwiritsidwe ntchito ngati chomangira, disintegrant, ❖ kuyanika zakuthupi ndi ankalamulira kumasulidwa mafupa zakuthupi mu mapiritsi.
Binder:HPMC angagwiritsidwe ntchito ngati binder mu chonyowa granulation kapena youma granulation kusintha tinthu mphamvu, piritsi kuuma ndi makina bata la mankhwala.
Disintegrant:Otsika mamasukidwe akayendedwe HPMC angagwiritsidwe ntchito ngati disintegrant kulimbikitsa piritsi azingokhala ndi kuonjezera mlingo Kutha mankhwala pambuyo kutupa chifukwa cha mayamwidwe madzi.
Zomatira:HPMC ndi chimodzi mwa zinthu zazikulu ❖ kuyanika piritsi, amene akhoza kusintha maonekedwe a mankhwala, kubisa kukoma zoipa mankhwala, ndipo angagwiritsidwe ntchito ❖ kuyanika enteric kapena filimu ❖ kuyanika ndi plasticizers.
Zinthu zotulutsidwa zoyendetsedwa: High-viscosity HPMC itha kugwiritsidwa ntchito ngati chigoba kuti achedwetse kutulutsidwa kwa mankhwala ndikukwaniritsa kumasulidwa kokhazikika kapena koyendetsedwa. Mwachitsanzo, HPMC K4M, HPMC K15M ndi HPMC K100M nthawi zambiri amagwiritsidwa ntchito pokonzekera mapiritsi otulutsidwa.
2.2 Ntchito mu kapisozi kukonzekera
HPMC itha kugwiritsidwa ntchito popanga makapisozi opanda kanthu opangidwa ndi zomera kuti alowe m'malo mwa makapisozi a gelatin, omwe ndi oyenera kwa omwe amadya zamasamba ndi anthu omwe sakhudzidwa ndi makapisozi opangidwa ndi nyama. Kuphatikiza apo, HPMC itha kugwiritsidwa ntchito podzaza makapisozi amadzimadzi kapena a semisolid kuti apititse patsogolo kukhazikika komanso kutulutsa kwamankhwala.
2.3 Kugwiritsa ntchito mankhwala ophthalmic
HPMC, monga chigawo chachikulu cha misozi yokumba, akhoza kuonjezera mamasukidwe akayendedwe a madontho diso, kutalikitsa nthawi okhala mankhwala pa ocular padziko, ndi kusintha bioavailability. Kuphatikiza apo, HPMC itha kugwiritsidwanso ntchito pokonzekera ma gels amaso, makanema amaso, ndi zina zambiri, kuti apititse patsogolo kutulutsidwa kwamankhwala amaso.
2.4 Kugwiritsa ntchito pokonzekera zoperekera mankhwala apamutu
AnxinCel®HPMC ili ndi zinthu zabwino zopanga filimu komanso kuyanjana kwachilengedwe, ndipo itha kugwiritsidwa ntchito popanga zigamba za transdermal, gels ndi zonona. Mwachitsanzo, m'machitidwe operekera mankhwala osokoneza bongo, HPMC ikhoza kugwiritsidwa ntchito ngati matrix kuti awonjezere kuchuluka kwa mankhwalawa ndikutalikitsa nthawi yochitapo kanthu.
2.5 Kugwiritsa ntchito madzi amkamwa ndi kuyimitsidwa
HPMC angagwiritsidwe ntchito monga thickener ndi stabilizer kusintha rheological katundu wa m`kamwa madzi ndi kuyimitsidwa, kuteteza particles olimba kukhazikika, ndi kusintha yunifolomu ndi bata la mankhwala.
2.6 Kugwiritsa ntchito pokonzekera pokoka mpweya
HPMC ikhoza kugwiritsidwa ntchito ngati chonyamulira cha ufa wowuma inhalers (DPIs) kuti apititse patsogolo kusungunuka kwa mankhwala ndi dispersibility, kuonjezera kuchuluka kwa mankhwala m'mapapo, motero kumapangitsanso chithandizo chamankhwala.
3. Ubwino wa HPMC pokonzekera kumasulidwa kosalekeza
HPMC ili ndi izi monga chothandizira kumasulidwa kosatha:
Kusungunuka kwamadzi bwino:Imatha kutupa m'madzi mwachangu kuti ipange chotchinga cha gel ndikuwongolera kuchuluka kwa mankhwala.
Kulumikizana kwabwino kwa biocompatibility:zopanda poizoni komanso zosakwiyitsa, zomwe sizimatengedwa ndi thupi la munthu, ndipo zimakhala ndi njira yodziwika bwino ya metabolic.
Kusinthasintha kwamphamvu:Oyenera mitundu yosiyanasiyana ya mankhwala, kuphatikizapo madzi sungunuka ndi hydrophobic mankhwala.
Njira yosavuta:Oyenera zosiyanasiyana kukonzekera njira monga mwachindunji piritsi ndi chonyowa granulation.
Monga chothandizira chofunikira chamankhwala,Mtengo wa HPMCchimagwiritsidwa ntchito m'madera ambiri monga mapiritsi, makapisozi, ophthalmic kukonzekera, topical kukonzekera, etc., makamaka pokonzekera mosalekeza-kumasulidwa. M'tsogolomu, ndi chitukuko chosalekeza cha teknoloji yokonzekera mankhwala, kuchuluka kwa ntchito kwa AnxinCel®HPMC kudzakulitsidwanso, kupatsa makampani opanga mankhwala njira zowonjezera komanso zotetezeka za excipient.
Nthawi yotumiza: Feb-08-2025