Kwicandelo lezemithi, i-sodium carboxymethylcellulose (CMC) kunye ne-hydroxypropyl methylcellulose (HPMC) zizinto ezimbini ezisetyenziswa kakhulu kwi-pharmaceutical excipients ezineempawu ezahlukeneyo zeekhemikhali kunye nemisebenzi.
Ulwakhiwo lweekhemikhali kunye neempawu zazo
I-CMC yi-cellulose derivative enyibilikayo emanzini efunyenwe ngokuguqula inxalenye yamaqela e-hydroxyl e-cellulose ibe ngamaqela e-carboxymethyl. Ukunyibilika kwamanzi kunye ne-viscosity ye-CMC kuxhomekeke kwinqanaba layo lokutshintsha kunye nobunzima be-molecular, kwaye idla ngokusebenza njenge-thickener kunye ne-agent yokumisa.
I-HPMC ifunyanwa ngokutshintsha inxalenye yamaqela e-hydroxyl e-cellulose ngamaqela e-methyl kunye ne-hydroxypropyl. Xa ithelekiswa ne-CMC, i-HPMC inokunyibilika okubanzi, inokunyibilika emanzini abandayo nashushu, kwaye ibonisa i-viscosity ezinzileyo kwiixabiso ezahlukeneyo ze-pH. I-HPMC idla ngokusetyenziswa njenge-film former, i-adhesive, i-thickener kunye ne-release agent elawulwayo kwi-pharmaceuticals.
Intsimi yesicelo
Iipilisi
Kwimveliso yeepilisi, i-CMC isetyenziswa kakhulu njengento ekhupha amanzi kunye nenamathelayo. Njengento ekhupha amanzi, i-CMC inokufunxa amanzi ize idumbe, ngaloo ndlela ikhuthaze ukuqhekeka kweepilisi kwaye yonyuse izinga lokukhululwa kwamayeza. Njengento edibanisayo, i-CMC inokuphucula amandla oomatshini eepilisi.
I-HPMC isetyenziswa kakhulu njengesixhobo sokukhulula iifilimu esisetyenziswa kwiipilisi. Ifilimu eyenziwe yi-HPMC inamandla abalaseleyo oomatshini kunye nokumelana nokuguguleka, nto leyo enokukhusela iyeza kwimpembelelo yokusingqongileyo kwangaphandle. Kwangaxeshanye, iipropati zokwenza ifilimu ze-HPMC zingasetyenziselwa ukulawula izinga lokukhululwa kweziyobisi. Ngokulungisa uhlobo kunye nomthamo we-HPMC, ukukhululwa okuqhubekayo okanye isiphumo sokukhululwa esilawulwayo sinokufezekiswa.
Iikhaphu
Xa kulungiswa iikhaphu, i-CMC ayisetyenziswa kakhulu, ngelixa i-HPMC isetyenziswa kakhulu, ingakumbi ekuvelisweni kweekhaphu zemifuno. Iikhaphu zemveli zemveli zenziwe nge-gelatin, kodwa ngenxa yengxaki yemithombo yezilwanyana, i-HPMC iye yaba yinto efanelekileyo yokutshintsha. Ikhaphu lekhaphu elenziwe nge-HPMC aligcini nje ngokuba ne-biocompatibility elungileyo, kodwa likwahlangabezana neemfuno zabantu abatya imifuno.
Amalungiselelo olulwelo
Ngenxa yeempawu zayo ezintle zokutyeba kunye nokuxhoma, i-CMC isetyenziswa kakhulu kumalungiselelo olwelo afana nezisombululo zomlomo, amaconsi amehlo kunye namalungiselelo angaphandle. I-CMC inokunyusa ukuxinana kwamalungiselelo olwelo, ngaloo ndlela iphucula ukuxhoma kunye nokuzinza kwamayeza kwaye ithintele ukubola kwamayeza.
Ukusetyenziswa kwe-HPMC kumalungiselelo olulwelo kugxile kakhulu kwi-thickeners kunye ne-emulsifiers. I-HPMC inokuhlala izinzile kuluhlu olubanzi lwe-pH kwaye ingahambelana neentlobo ngeentlobo zamayeza ngaphandle kokuchaphazela ukusebenza kakuhle kwamayeza. Ukongeza, iipropati zokwenza ifilimu ze-HPMC zikwasetyenziswa kumalungiselelo angaphandle, njengesiphumo sokukhusela esenziwe ifilimu kumaconsi amehlo.
Amalungiselelo okukhululwa alawulwayo
Kumalungiselelo okukhululwa alawulwayo, ukusetyenziswa kwe-HPMC kubaluleke kakhulu. I-HPMC iyakwazi ukwenza inethiwekhi yejeli, kwaye izinga lokukhululwa kwamayeza linokulawulwa ngokulungelelanisa uxinaniso kunye nolwakhiwo lwe-HPMC. Le propati isetyenziswa kakhulu kwiipilisi ezikhutshwayo ezihlala zisetyenziswa ngomlomo kunye nee-implants. Ngokwahlukileyo koko, i-CMC ayisetyenziswa kakhulu kumalungiselelo okukhululwa alawulwayo, ikakhulu ngenxa yokuba ulwakhiwo lwejeli oluyilwayo aluzinzanga njenge-HPMC.
Uzinzo kunye nokuhambelana
I-CMC ayinazinzo zingako kwii-pH ezahlukeneyo kwaye ichaphazeleka lula ziindawo ezisekelwe kwi-asidi. Ukongeza, i-CMC ayihambelani kakuhle nezithako ezithile zamayeza, nto leyo enokubangela ukuba ichiza liwe okanye lingaphumeleli.
I-HPMC ibonisa uzinzo oluhle kuluhlu olubanzi lwe-pH, ayichaphazeleki lula yi-acid-base, kwaye ihambelana kakuhle. I-HPMC ingahambelana nezithako ezininzi zamayeza ngaphandle kokuchaphazela uzinzo kunye nokusebenza kakuhle kwamayeza.
Ukhuseleko kunye nemigaqo
Zombini i-CMC kunye ne-HPMC zithathwa njengezinto ezikhuselekileyo zokuncedisa amayeza kwaye zivunyiwe ukuba zisetyenziswe kumalungiselelo amayeza yi-pharmacopoeias kunye neearhente ezilawulayo kumazwe ahlukeneyo. Nangona kunjalo, ngexesha lokusetyenziswa, i-CMC inokubangela ezinye iimpembelelo ze-allergy okanye ukungakhululeki kwesisu, ngelixa i-HPMC ingaqhelekanga ukubangela iimpembelelo ezimbi.
I-CMC kunye ne-HPMC zineengenelo zazo kwizicelo zamayeza. I-CMC ithatha indawo ebalulekileyo kumalungiselelo olwelo ngenxa yeempawu zayo ezibalaseleyo zokutyeba kunye nokuxhonywa, ngelixa i-HPMC isetyenziswa kakhulu kwiipilisi, iikhaphu kunye namalungiselelo okukhululwa alawulwayo ngenxa yeempawu zayo ezibalaseleyo zokwenza ifilimu kunye nokukhululwa okulawulwayo. Ukukhethwa kwamalungiselelo amayeza kufuneka kusekelwe kwiimpawu ezithile zamayeza kunye neemfuno zokulungiswa, kuqwalaselwa ngokupheleleyo iingenelo kunye nokungalungi kwazo zombini, kwaye kukhethwe eyona nto ifanelekileyo.
Ixesha leposi: Julayi-19-2024