Hydroxypropyl Methylcellulose (HPMC)waa ether nonionic cellulose ah oo leh filim-samayn wanaagsan, dhejis, dhumuc iyo kontaroolo siideynta guryaha, waxaana si weyn loogu isticmaalaa warshadaha dawooyinka. Kaabsoosha daawada, AnxinCel®HPMC waxaa loo isticmaali karaa kaniiniyada, kaabsaloyinka, diyaarinta sii-deynta joogtada ah, diyaarinta indhaha iyo hababka gudbinta daawada jirka la mariyo.
1. sifooyinka physicochemical ee HPMC
HPMC waa maaddo polymer semi-synthetic ah oo lagu helo methylating iyo hydroxypropylating cellulose dabiiciga ah, oo leh milmayn biyo aad u fiican iyo nooleyaal. Milicsanaanteeda ayaa saameyn yar ku yeelanaysa heerkulka iyo qiimaha pH, waxayna ku barari kartaa biyaha si ay u sameeyaan xal viscous ah, kaas oo ka caawiya sii deynta la xakameeyey ee daroogada. Marka loo eego viscosity-ka, HPMC waxa loo qaybin karaa saddex qaybood: mawqif hoose (5-100 mPa·s), viscosity dhexdhexaad ah (100-4000 mPa·s) iyo viscosity sare (4000-100000 mPa·s), kuwaas oo ku habboon shuruudaha diyaarinta ee kala duwan.
2. Codsiga HPMC ee diyaarinta dawooyinka
2.1 Codsiga kiniinka
HPMC waxa loo isticmaali karaa sida xidhe, kala daadsan, shay dahaadh ah iyo walxo la xakameeyey oo la soo daayay oo kiniinno ah.
Xargaha:HPMC waxa loo isticmaali karaa sida xidhe ee granulation qoyan ama granulation qalalan si loo hagaajiyo xoogga walxaha, adkaanta kiniinka iyo xasiloonida farsamada ee daroogada.
Kala daadsan:Viscosity-hooseeya HPMC waxa loo isticmaali karaa kala furfurid ahaan si kor loogu qaado kala daadsanaanta kiniinka iyo kordhinta heerka kala dirida daroogada ka dib bararka ay sabab u tahay nuugista biyaha.
Qalabka dahaarka:HPMC waa mid ka mid ah qalabka ugu muhiimsan ee daahan kaniiniga, kaas oo hagaajin kara muuqaalka mukhaadaraadka, dabooli kara dhadhanka xun ee daroogooyinka, waxaana loo isticmaali karaa dahaarka gudaha ama dahaarka filimada leh balaastikada.
Walxaha siidaynta la kontoroolo: HPMC-viskosity-sare waxaa loo isticmaali karaa sidii walxo qalfoof ah si loo daahiyo sii deynta daroogada laguna gaaro sii deyn joogto ah ama la xakameeyey. Tusaale ahaan, HPMC K4M, HPMC K15M iyo HPMC K100M ayaa inta badan loo isticmaalaa diyaarinta kiniinada la xakameeyey.
2.2 Codsiga diyaarinta kaabsal
HPMC waxa loo isticmaali karaa in lagu soo saaro kaabsal godan oo laga keenay geedo si loogu beddelo kaabsalka jelatin, kuwaas oo ku habboon khudaarleyda iyo dadka xasaasiyadda ka qaba kaabsoosha xoolaha ka soo jeeda. Intaa waxaa dheer, HPMC waxaa loo isticmaali karaa buuxinta dareeraha ama kaabsalka semisolid si loo hagaajiyo xasilloonida iyo sii deynta sifooyinka daroogada.
2.3 Codsiga diyaarinta indhaha
HPMC, oo ah qaybta ugu muhiimsan ee ilmada macmalka ah, waxay kordhin kartaa viscosity ee dhibcaha indhaha, waxay dheerayn kartaa wakhtiga degenaanshaha daroogada ee dusha indhaha, waxayna hagaajinaysaa bioavailability. Intaa waxaa dheer, HPMC sidoo kale waxaa loo isticmaali karaa in lagu diyaariyo jellaha indhaha, filimada indhaha, iwm, si loo hagaajiyo saameynta sii daynta joogtada ah ee daawooyinka indhaha.
2.4 Codsiga diyaarinta gaarsiinta daawada jirka la mariyo
AnxinCel®HPMC waxay leedahay sifooyin samaynta aflaanta oo wanaagsan iyo noole la jaanqaadi kara, waxaana loo isticmaali karaa in lagu diyaariyo balastar, jeel iyo kareemyo. Tusaale ahaan, nidaamyada gudbinta dawooyinka transdermal, HPMC waxaa loo isticmaali karaa walxo matrix ah si loo kordhiyo heerka gelitaanka daroogada oo loo kordhiyo muddada ficilka.
2.5 Codsiga dareeraha afka iyo ka joojinta
HPMC waxa loo isticmaali karaa sidii dhumuc iyo xasiliye si loo hagaajiyo sifooyinka rheological ee dareeraha afka iyo hakinta, ka hortagga walxaha adag in ay dejiyaan, iyo hagaajinta isku midka ah iyo xasiloonida daroogada.
2.6 Codsiga diyaarinta neefsashada
HPMC waxaa loo isticmaali karaa sida side budada qalalan ee neef-qaadayaasha (DPI) si loo hagaajiyo dareeraha iyo kala firdhinta daawooyinka, kordhinta heerka kaydinta sambabada ee daawooyinka, oo sidaas awgeed kor loogu qaado saameynta daaweynta.
3. Faa'iidooyinka HPMC ee diyaarinta sii-deynta joogtada ah
HPMC waxay leedahay sifooyin soo socda oo ah sii dayn joogto ah:
Biyo wanaagsan:Waxay si dhakhso ah u barari kartaa biyaha si ay u sameyso xannibaad jel oo ay nidaamiso heerka sii deynta daroogada.
Laqabsiga noole ee wanaagsan:aan sun ahayn oo aan xanaaqin, oo aan la nuugin jidhka bini'aadamka, oo leh dariiq dheef-shiid kiimikaad oo cad.
Laqabsiga xooggan:Ku habboon noocyada kala duwan ee dawooyinka, oo ay ku jiraan dawooyinka biyaha-milla iyo hydrophobic.
Habka fudud:Ku habboon hababka diyaarinta ee kala duwan sida kiniiniga tooska ah iyo granulation qoyan.
Sida qayb muhiim ah oo ka mid ah dawooyinka,HPMCwaxaa si weyn loogu isticmaalaa meelo badan sida kiniiniyada, kaabsal, diyaarinta indhaha, diyaarinta jirka, iwm, gaar ahaan diyaarinta sii-daynta joogtada ah. Mustaqbalka, iyadoo horumarinta joogtada ah ee tignoolajiyada diyaarinta dawooyinka, baaxadda codsiga ee AnxinCel®HPMC waa la sii ballaarin doonaa, iyadoo siinaya warshadaha dawooyinka xulashooyin waxtar leh oo hufan oo ammaan ah.
Waqtiga boostada: Feb-08-2025