Hydroxypropyl Methylcellulose (HPMC)ni nonionic selulose ether ifite firime nziza, ifata, ikabyimba kandi igenzurwa, kandi ikoreshwa cyane mubikorwa bya farumasi. Nkibikoresho bya farumasi, AnxinCel®HPMC irashobora gukoreshwa mubinini, capsules, imyiteguro irekura-irekuye, imyiteguro y’amaso hamwe na sisitemu yo gutanga imiti yibanze.
1. Imiterere yumubiri ya HPMC
HPMC ni igice cya sintetike ya polymer iboneka hakoreshejwe methylating na hydroxypropylating naturulose naturel, hamwe no gukurura amazi meza hamwe na biocompatibilité. Ubushobozi bwabwo ntibwatewe cyane nubushyuhe nagaciro ka pH, kandi burashobora kubyimba mumazi kugirango bibe igisubizo kiboneye, gifasha kurekura ibiyobyabwenge kugenzura. Ukurikije ububobere, HPMC irashobora kugabanywamo ibyiciro bitatu: ubukonje buke (5-100 mPa · s), ubukonje buciriritse (100-4000 mPa · s) hamwe nubukonje bwinshi (4000-100000 mPa · s), bukwiranye nibisabwa bitandukanye byo kwitegura.
2. Gukoresha HPMC mugutegura imiti
2.1 Gushyira mu bisate
HPMC irashobora gukoreshwa nkibikoresho, bidahwitse, bipfundikanya kandi bigenzurwa-bisohora skeleton yibikoresho.
Binder:HPMC irashobora gukoreshwa nkumuhuza mugusya neza cyangwa guhunika byumye kugirango utezimbere imbaraga zingirakamaro, gukomera kwa tablet hamwe nubukanishi bwibiyobyabwenge.
Gutandukana:HPMC ifite ubukonje buke irashobora gukoreshwa nkibidahwitse kugirango itume ibinini bisenyuka kandi byongere umuvuduko w’ibiyobyabwenge nyuma yo kubyimba bitewe no gufata amazi.
Ibikoresho byo gutwikira:HPMC ni kimwe mu bikoresho by'ingenzi byo gutwikira ibinini, bishobora kunoza isura y'ibiyobyabwenge, bigapfukirana uburyohe bubi bw'ibiyobyabwenge, kandi birashobora gukoreshwa mu gutwikira enterineti cyangwa gutwikisha firime hamwe na plastike.
Ibikoresho bigenzurwa-kurekura: HPMC ifite ubukana bwinshi irashobora gukoreshwa nkibikoresho bya skeleton kugirango itinde kurekura ibiyobyabwenge no kugera kurekurwa kuramba cyangwa kugenzurwa. Kurugero, HPMC K4M, HPMC K15M na HPMC K100M ikoreshwa mugutegura ibinini bigenzurwa-bisohora.
2.2 Gushyira mubikorwa bya capsule
HPMC irashobora gukoreshwa mugukora ibihingwa biva mu bimera biva mu bimera kugira ngo bisimbuze gelatine capsules, ibereye ibikomoka ku bimera ndetse n’abantu bafite allergie kuri capsules ikomoka ku nyamaswa. Byongeye kandi, HPMC irashobora gukoreshwa mukuzuza capsules yamazi cyangwa semisolide kugirango itezimbere kandi irekure imiti.
2.3 Gushyira mubikorwa byamaso
HPMC, nkigice cyingenzi cyamarira yubukorikori, irashobora kongera ubwiza bwigitonyanga cyamaso, ikongerera igihe cyo gutura ibiyobyabwenge kumaso ya ocular, kandi bigatera bioavailable. Byongeye kandi, HPMC irashobora kandi gukoreshwa mugutegura gele yijisho, firime yijisho, nibindi, kugirango habeho ingaruka zihoraho zo kurekura imiti yijisho.
2.4 Gusaba muburyo bwo gutegura ibiyobyabwenge
AnxinCel®HPMC ifite imiterere myiza yo gukora firime hamwe na biocompatibilité, kandi irashobora gukoreshwa mugutegura ibibyimba bya transdermal, geles na cream. Kurugero, muri sisitemu yo gutanga imiti ya transdermal, HPMC irashobora gukoreshwa nkibikoresho bya matrix kugirango yongere ibiyobyabwenge byinjira kandi byongere igihe cyibikorwa.
2.5 Gusaba mumazi yo munwa no guhagarikwa
HPMC irashobora gukoreshwa nkibyimbye hamwe na stabilisateur kugirango itezimbere imiterere yimiterere yimyunyu ngugu yo mu kanwa no guhagarikwa, irinde uduce twinshi gutuza, kandi tunoze uburinganire nuburinganire bwibiyobyabwenge.
2.6 Gushyira mubikorwa byo guhumeka
HPMC irashobora gukoreshwa nk'itwara ryangiza ifu yumye (DPIs) kugirango itezimbere kandi ikwirakwizwa ryibiyobyabwenge, byongere umuvuduko wibihaha byibiyobyabwenge, bityo byongere ingaruka zo kuvura.
3. Ibyiza bya HPMC mugutegura-kurekura
HPMC ifite ibimenyetso bikurikira nkibi bikomeza-kurekura:
Amazi meza yo gukemura:Irashobora kubyimba vuba mumazi kugirango ibe inzitizi ya gel kandi igabanye igipimo cyo kurekura ibiyobyabwenge.
Biocompatibilité nziza:idafite uburozi kandi budatera uburakari, ntibwinjizwa n'umubiri w'umuntu, kandi bufite inzira isobanutse.
Guhuza n'imihindagurikire y'ikirere:Bikwiranye nubwoko butandukanye bwibiyobyabwenge, harimo imiti ikurura amazi na hydrophobique.
Inzira yoroshye:Birakwiriye muburyo butandukanye bwo kwitegura nka tableti itaziguye hamwe na granulation itose.
Nkibikoresho byingenzi bya farumasi,HPMCikoreshwa cyane mubice byinshi nka tableti, capsules, imyiteguro y'amaso, imyiteguro yibanze, nibindi, cyane cyane mubitegura-kurekura. Mu bihe biri imbere, hamwe n’iterambere rihoraho ry’ikoranabuhanga ritegura imiti, urugero rwa AnxinCel®HPMC ruzagurwa kurushaho, rutange inganda z’imiti n’uburyo bunoze kandi bwizewe.
Igihe cyo kohereza: Gashyantare-08-2025