Ngwa nke Hydroxypropyl Methylcellulose (HPMC) dị ka ihe mgbakwunye ọgwụ na nkwadebe.

1. Njirimara physicochemical nke HPMC

HPMC bụ ihe polymer synthetic nke ọkara nke enwetara site na methylating na hydroxypropylating cellulose eke, nwere ezigbo mmiri solubility na biocompatibility. Ọdịmma ya adịghị emetụta okpomọkụ na uru pH, ọ pụkwara ịza na mmiri iji mepụta ngwọta viscous, nke na-enyere aka ntọhapụ nke ọgwụ ọjọọ. Dị ka viscosity si kwuo, HPMC nwere ike kewaa ụzọ atọ: obere viscosity (5-100 mPa·s), viscosity ọkara (100-4000 mPa·s) na nnukwu viscosity (4000-100000 mPa·s), nke dabara maka ihe dị iche iche nkwadebe chọrọ.

2. Ngwa nke HPMC na nkwadebe ọgwụ

2.1 Ngwa na mbadamba
Enwere ike iji HPMC dị ka ihe nkedo, mgbasa, ihe mkpuchi na ihe a na-ejikwa skeleton na mbadamba.
Ihe nkedo:HPMC nwere ike ji mee ihe dị ka ihe nkedo na mmiri granulation ma ọ bụ akọrọ granulation ka mma urughuru ike, mbadamba ike ike na n'ibu kwụsie ike nke ọgwụ ọjọọ.
Nkewa:Enwere ike iji HPMC nwere viscosity dị ala dị ka ihe na-agbasa iji kwalite mgbasa mbadamba nkume na ịbawanye ọnụego mgbasa ọgwụ ọgwụ mgbe ọzịza gasịrị n'ihi mmịnye mmiri.
Ihe mkpuchi:HPMC bụ otu n'ime ihe ndị bụ isi maka mkpuchi mbadamba nkume, nke nwere ike ime ka ọdịdị nke ọgwụ dịkwuo mma, kpuchie uto ọjọọ nke ọgwụ ọjọọ, a pụkwara iji ya na mkpuchi enteric ma ọ bụ mkpuchi ihe nkiri na plasticizers.
Ihe ntọhapụ a na-achịkwa: Enwere ike iji HPMC nwere viscosity dị elu dị ka ihe ọkpụkpụ iji gbuo oge ntọhapụ ọgwụ wee nweta ntọhapụ ma ọ bụ na-achịkwa. Dịka ọmụmaatụ, a na-ejikarị HPMC K4M, HPMC K15M na HPMC K100M akwadebe mbadamba ihe na-achịkwa.

2.2 Ngwa na nkwadebe capsule
Enwere ike iji HPMC mepụta capsules oghere nke sitere na osisi iji dochie capsules gelatin, nke dabara maka ndị anaghị eri anụ na ndị na-enwe nfụkasị na capsules sitere na anụmanụ. Na mgbakwunye, enwere ike iji HPMC mejupụta mmiri mmiri ma ọ bụ capsules semisolid iji melite nkwụsi ike na ntọhapụ nke ọgwụ.

2.3 Ngwa na nkwadebe ophthalmic
HPMC, dị ka isi akụrụngwa nke artificial anya mmiri, nwere ike dịkwuo viscosity nke anya tụlee, ogologo oge obibi nke ọgwụ ọjọọ n'elu ocular elu, na melite bioavailability. Na mgbakwunye, HPMC nwekwara ike iji kwadebe gels anya, ihe nkiri anya, wdg, iji meziwanye mmetụta ntọhapụ nke ọgwụ anya.

2.4 Ngwa na nkwadebe nnyefe ọgwụ
AnxinCel®HPMC nwere ezigbo ihe na-emepụta ihe nkiri na ihe ndakọrịta, enwere ike iji ya dozie patches transdermal, gels na creams. Dịka ọmụmaatụ, na usoro nnyefe ọgwụ transdermal, HPMC nwere ike iji dị ka ihe matriks iji mee ka ọnụ ọgụgụ ntinye ọgwụ dị ogologo ma gbatịa ogologo oge.