Ukusetshenziswa kwe-HPMC embonini yezemithi

I-Hydroxypropyl methylcellulose (HPMC)iyi-non-ionic cellulose ether eyenziwe nge-polymer cellulose yemvelo ngokuguqulwa kwamakhemikhali. Ine-solubility enhle, i-biocompatibility kanye nezakhiwo zokwakha ifilimu. Ngenxa yokuphepha kwayo okuphezulu kanye nobuthi obuphansi, isetshenziswa kabanzi embonini yezemithi njengesithako sethebhulethi, izinto ezikhishwa njalo, i-ejenti yokumboza, izinto ze-capsule, njll., futhi idlala indima ebalulekile ekulungiseleleni okuqinile, ekulungiseleleni uketshezi kanye nasekulungiseleleni okukhishwayo okulawulwayo.

1. Ukusetshenziswa kwe-HPMC kumaphilisi

Njengesibophezeli

Uma i-HPMC isetshenziswa njenge-binder kumaphilisi, ivame ukungezwa ngesimo sesisombululo samanzi noma isixazululo samanzi esinotshwala, esingathuthukisa ngempumelelo amandla okubopha phakathi kwezimpushana zemithi, ngaleyo ndlela sithuthukise ukuqina nokumelana kokucindezela kwamaphilisi. Ngesikhathi esifanayo, ingathuthukisa nokusebenza koketshezi kanye nokufakwa kwamaphilisi, futhi iqinisekise ukufana kanye nekhwalithi yokubumba kwamalungiselelo.

Njengomuntu ohlukanisile

Nakuba i-HPMC inobuthi obuthile, inokuvuvukala okuhle kanye nokumuncwa kwamanzi emazingeni aphansi obuthi, ingamunca ngokushesha ujusi wesisu noma amanzi, futhi ikhuthaze ukubola kwethebhulethi ngemva kokukhula. Ngakho-ke, ubuthi obuphansi be-HPMC buvame ukusetshenziswa njengesithako ekulungiseleleni ukukhululwa okusheshayo.

Izinto zesikelethi ezikhishwa ngokulawulwa

I-HPMC ingakha ungqimba lwejeli oketshezini lwesisu ukuze inciphise izinga lokusabalala kwamanzi nemithi. Ngakho-ke, isetshenziswa kabanzi ekulungiseleleni amaphilisi akhishwa njalo, amaphilisi akhishwa ngokulawulwa kanye nezinye izinto eziqinile zomlomo. Ivame ukusetshenziswa ngokuhlanganiswa namanye ama-polymer aphilizayo (njenge-PVP, i-carbomer, njll.) ukwakha uhlelo oluzinzile lokukhishwa kwemithi.

2. Ukusetshenziswa kwe-HPMC ekumbozweni kwethebhulethi

I-HPMC inezakhiwo ezinhle zokwakha ifilimu kanye nokucaca kwayo futhi ingenye yezinto ezisetshenziswa kakhulu ekumbozeni ifilimu yamathebhulethi. Uma kuqhathaniswa nokugqoka ushukela kwendabuko noma ukugqoka i-polymer encibilikayo emanzini, ifilimu ye-HPMC inezinzuzo ezilandelayo:

Ukwakheka kwefilimu okusheshayo, okubushelelezi futhi okuhle;

Ukusebenza kokukhululwa okulungisekayo;

Isivikelo esihle samaphilisi, ukumelana nomswakama kanye nokulwa ne-oxidation;

Ingasetshenziswa kanye nezinhlobo ezahlukene ze-plasticizers (njenge-PEG, i-triacetin, njll.) ukulungisa ukuguquguquka kwesendlalelo sefilimu;

Incibilika ezinhlotsheni ezahlukene zezincibilikisi (amanzi, i-ethanol, izincibilikisi ezixubile zamanzi notshwala, njll.), ezivumelana nezinqubo ezahlukene zokulungiselela.

Isimbozo se-HPMC sivame ukusetshenziselwa ukulungisa isimbozo se-enteric, isimbozo esikhishwa njalo kanye nesimbozo esivikelayo ukuze kuhlotshiswe ukubukeka.

3. Ukusetshenziswa kwe-HPMC kuma-capsule

Izinto zokusetshenziswa ze-capsule yesitshalo

I-HPMC iyi-cellulose derivative etholakala ezitshalweni, engathatha indawo ye-gelatin njengento eyinhloko eluhlaza yegobolondo le-capsule ukwenza "ama-capsule ezitshalo". Uma kuqhathaniswa nama-capsule e-gelatin ezilwane, ama-capsule e-HPMC anezinzuzo ezilandelayo:

Azikho izithako zezilwane, ezifanele abantu abadla imifino kanye nabantu bezinkolo ezithile;

Ukuqina okuphezulu, ukungazweli ekushintsheni kwezinga lokushisa kanye nomswakama;

Ukwehla kwe-hygroscopicity kanye namandla angcono okusebenza, okwandisa isikhathi sokuphila kwemithi;

Kulula ukugcwalisa nokuvala, kufanelekile imishini yokugcwalisa i-capsule enembile kakhulu.

Izinto zokupakisha ze-microcapsule yokukhululwa elawulwayo

Kwezinye izinhlelo zokukhulula ezilawulwa yi-microcapsule, i-HPMC ingasetshenziswa futhi njengento yodonga, isebenza ndawonye namanye ama-polymer ukuze kufezwe ukukhishwa kwemithi kancane emzimbeni ngokulungisa ukujiya kanye nesilinganiso sokuncibilika.

4. Ukusetshenziswa kwe-HPMC kumalungiselelo oketshezi

Emaconsini amehlo, izixazululo zomlomo kanye nemithi yokwelapha, i-HPMC ivame ukusetshenziswa njengesithambisi, isiqinisi kanye nesinamathelisi:

Amaconsi Eso: I-HPMC isetshenziswa njengesithambisi sokwandisa isikhathi sokuhlala kwamaconsi eliso ebusweni be-cornea, ukuthuthukisa ukusebenza kahle komuthi, nokuqeda izimpawu zamehlo omile.

Imithi yoketshezi ephuzwayo: yandisa ukujiya kwesisombululo, ithuthukise ukunambitheka, futhi ivimbele imvula.

Ukulungiswa kwesikhumba: njengamajeli, amafutha okugcoba, okhilimu, njll., i-HPMC ingathuthukisa ukusebenza kwayo kokumboza kanye nokunamathela kwesikhumba, futhi ithuthukise ulwazi lomsebenzisi.

5. Ukuphepha kanye nokuvunyelwa komthetho

I-HPMC iyi-excipient yemithi eqinisekiswe yi-FDA kanye ne-EU EMA, futhi ihlangabezana nezindinganiso ze-pharmacopoeias ezahlukahlukene (njenge-USP, Ph. Eur., JP, njll.). Inobuthi obuphansi, ihambisana kahle nezinto eziphilayo, futhi ayibangeli ukusabela kokungezwani komzimba. Iyisithako esiphephile esaziwayo futhi sisetshenziswa kabanzi ekulungiseleleni ngomlomo nangaphandle.

6. Izitayela zentuthuko yesikhathi esizayo

Ngokuthuthuka kwemibono yezokwelapha eluhlaza neyobungani nemvelo kanye nokwanda kokungadli imifino, amathuba okusetshenziswa kwe-HPMC kuma-capsule ezitshalo kanye namalungiselelo okukhululwa okulawulwayo abanzi kakhulu. Ucwaningo nge-HPMC esebenza kahle kakhulu (njenge-HPMC eguquliwe ekhethekile) ekukhishweni kwemithi okuqondiwe, ukukhululwa okulawulwayo okulawulwayo okuhlakaniphile, njll. nalo luya luba lusebenza kakhulu, okuzothuthukisa ukusetshenziswa kwalo emkhakheni wemithi ephezulu.

Njenge-multifunctional futhi ephephile kakhuluisithako semithi I-HPMCidlala indima ebaluleke kakhulu embonini yezemithi. Kusukela ezintweni ezisizayo zendabuko kanye nezinto zokumboza kuya ezithwalini zokukhulula ezilawulwayo zesimanje kanye nezinto ze-capsule yezitshalo, ukusetshenziswa kwayo kukhula njalo futhi kungenye yezingxenye ezibalulekile zokulungiselela imithi yesimanje.