Kushandiswa kweHPMC muindasitiri yemishonga

Hydroxypropyl methylcellulose (HPMC)i non-ionic cellulose ether yakagadzirwa ne natural polymer cellulose ne chemical modification. Ine qualibility yakanaka, biocompatibility uye firimu-forming properties. Nekuda kwekuchengetedzwa kwayo kwakanyanya uye chepfu shoma, inoshandiswa zvakanyanya muindasitiri yemishonga semubatsiri wepiritsi, zvinhu zvinosunungura nguva dzose, coating agent, capsule material, nezvimwewo, uye inoita basa rakakosha mukugadzirira kwakasimba, kugadzira mvura uye kugadzira zvinhu zvinodzora.

1. Kushandiswa kweHPMC mumapiritsi

Sechisungo

Kana HPMC ichishandiswa sechinobatanidza mumapiritsi, inowanzowedzerwa muchimiro chemvura kana mvura ine doro, izvo zvinogona kuvandudza simba rekubatanidza pakati pehupfu hwemishonga, nokudaro zvichiwedzera kuomarara uye kuramba kudzvanywa kwemapiritsi. Panguva imwe chete, inogonawo kuvandudza kuyerera uye kushanda kwemapiritsi, uye kuve nechokwadi chekuti mapiritsi akafanana uye ane mhando yekuumbwa.

Semunhu akaparadzana

Kunyangwe HPMC ine viscosity yakati, ine kuzvimba kwakanaka uye inonyudza mvura pamazinga akaderera e viscosity, inogona kunyudza muto wemudumbu kana mvura nekukurumidza, uye inokurudzira kuparara kwepiritsi mushure mekukura. Nokudaro, HPMC ine viscosity yakaderera inowanzoshandiswawo semushonga wekubvisa hutachiona mukugadzirira kwekukurumidzira kuburitsa hutachiona.

Zvinhu zvemapfupa zvinoburitswa zvinodzorwa

HPMC inogona kugadzira gel layer mumvura yemudumbu kuti ideredze kupararira kwemvura nemishonga. Nokudaro, inoshandiswa zvakanyanya mukugadzira mapiritsi anoburitswa kwenguva refu, mapiritsi anoburitswa nemuromo uye mamwe magadzirirwo akaoma. Inowanzo shandiswa pamwe chete nemamwe mapolymer anonyungudutsa mvura (akadai sePVP, carbomer, nezvimwewo) kuti igadzire hurongwa hwakasimba hwekuburitsa mishonga.

2. Kushandiswa kweHPMC mupurasitiki yekuputira

HPMC ine hunhu hwakanaka hwekugadzira firimu uye kujeka kwayo uye ndeimwe yezvinhu zvinowanzoshandiswa pakuputira firimu repiritsi. Kana ichienzaniswa nepurasitiki inoputira shuga yechinyakare kana purasitiki inonyungudika mumvura, firimu reHPMC rine zvakanakira zvinotevera:

Kugadzirwa kwefirimu nekukurumidza, kwakatsetseka uye kwakanaka;

Kugadziriswa kwekuburitsa mashandiro;

Dziviriro yakanaka pamapiritsi, haipindi hunyoro uye inodzivirira oxidation;

Inogona kushandiswa pamwe chete nemapurasitiki akasiyana-siyana (akadai sePEG, triacetin, nezvimwewo) kugadzirisa kuchinjika kwechikamu chefirimu;

Inonyungudika mumhando dzakasiyana-siyana dzezvinonyungudutsa (mvura, ethanol, zvinonyungudutsa zvakasanganiswa nemvura nedoro, nezvimwewo), inogona kushandiswa mukugadzirira kwakasiyana-siyana.

Kuputira kweHPMC kunowanzo shandiswa kugadzirira kuputira kwemukati, kuputira kunoburitsa zvinhu kwenguva refu uye kuputira kwekudzivirira kuti chitarisiko chionekwe zvakanaka.

3. Kushandiswa kweHPMC mumakapisi

Zvigadzirwa zvemuti zve capsule

HPMC chinhu chinobva mu cellulose chinobva mumiti, chinogona kutsiva gelatin sechinhu chikuru chekugadzira "capsules" yemuti. Kana tichienzanisa nemacapsules emhuka, macapsules eHPMC ane mabhenefiti anotevera:

Hapana zvinhu zvinoshandiswa pamhuka, zvakakodzera vanhu vanodya miriwo chete nevanhu vezvitendero zvakasiyana;

Kugadzikana kwakanyanya, kusanzwa kuchinja kwekushisa nehunyoro;

Kuderedza hygroscopicity uye simba remuchina riri nani, zvichiita kuti mishonga irambe iripo kwenguva refu;

Zviri nyore kuzadza nekuvhara, zvakakodzera michina yekuzadza kapisiyumu yakanyatsogadzirwa.

Zvinhu zvekurongedza zve microcapsule zvinodzorwa

Mune mamwe masisitimu ekuburitsa ma microcapsule anodzorwa, HPMC inogona kushandiswawo semadziro, ichishanda pamwe chete nemamwe ma polymers kuti mishonga ibude zvishoma nezvishoma mumuviri nekugadzirisa ukobvu uye mwero wekunyungudika.

4. Kushandiswa kweHPMC muzvigadzirwa zvemvura

Mumadonhwe emaziso, mishonga inonwiwa uye mishonga yemushonga, HPMC inowanzoshandiswa semushonga unosimbisa, unosimbisa uye unonamira:

Madonhwe emaziso: HPMC inoshandiswa semafuta ekuwedzera nguva yekugara kwemadonhwe emaziso pamusoro pekona, kuwedzera kushanda kwemushonga, uye kuderedza zviratidzo zvemaziso akaoma.

Mishonga inonwiwa nemuromo: inowedzera kunaka kwemushonga, inovandudza kuravira kwawo, uye inodzivirira kunaya kwemvura.

Kugadzirwa kweganda: zvakaita semagel, mafuta ekuzora, makirimu, nezvimwewo, HPMC inogona kuvandudza mashandiro avo ekuputira uye kunamira kweganda, uye kuwedzera ruzivo rwemushandisi.

5. Kuchengetedzwa uye mvumo yemutemo

HPMC mushonga unoshandiswa pakurapa wakabvumidzwa neFDA neEU EMA, uye unosangana nezvinodiwa zvemishonga yakasiyana-siyana (yakadai seUSP, Ph. Eur., JP, nezvimwewo). Haina chepfu yakawanda, haishande zvakanaka mumuviri, uye haikonzeri allergic reactions. Mushonga uyu wakachengeteka uye unoshandiswa zvakanyanya mukubika nekubika.

6. Mafambiro ebudiriro yeramangwana

Nekufambira mberi kwepfungwa dzemishonga dzinochengetedza nharaunda uye dzisingakuvadzi nharaunda uye kuwedzera kwekudya miriwo chete, mikana yekushandisa HPMC mumakapisi emiti uye mishonga inodzorwa yakawedzera. Tsvagiridzo pamusoro peHPMC inoshanda zvakanyanya (yakadai seHPMC yakagadziridzwa) mukuburitswa kwemishonga zvakanangana, kuburitswa kwemishonga inodzorwa nepfungwa, nezvimwewo iri kuramba ichishanda, izvo zvichasimudzira kushandiswa kwayo mumunda wemishonga yepamusoro.

Sebasa rinoshanda zvakasiyana-siyana uye rakachengeteka zvikurumushonga unobatsira HPMCine basa rakakosha zvikuru muindasitiri yemishonga. Kubva pazvinhu zvechinyakare zvinoshandiswa pakurapa nemishonga kusvika kuzvinhu zvemazuva ano zvinodzora mishonga uye zvinhu zvemakenduru emiti, kushandiswa kwayo kuri kuramba kuchikura uye chimwe chezvinhu zvakakosha pakugadzira mishonga yemazuva ano.