Kev siv HPMC hauv kev lag luam tshuaj

Hydroxypropyl methylcellulose (HPMC)yog ib qho cellulose ether uas tsis yog ionic ua los ntawm cov polymer cellulose ntuj los ntawm kev hloov kho tshuaj. Nws muaj kev yaj zoo, biocompatibility thiab cov khoom ua zaj duab xis. Vim nws muaj kev nyab xeeb siab thiab tsis muaj tshuaj lom, nws yog siv dav hauv kev lag luam tshuaj ua cov tshuaj ntsiav, cov khoom siv tso tawm tas mus li, tus neeg sawv cev txheej, cov khoom siv capsule, thiab lwm yam, thiab ua lub luag haujlwm tseem ceeb hauv kev npaj khoom khov, kev npaj kua thiab kev npaj tswj kev tso tawm.

1. Daim ntawv thov ntawm HPMC hauv cov ntsiav tshuaj

Ua ib daim ntawv khi

Thaum HPMC siv ua cov khoom sib txuas hauv cov ntsiav tshuaj, nws feem ntau ntxiv rau hauv daim ntawv ntawm cov kua dej lossis cov cawv dej, uas tuaj yeem txhim kho lub zog sib txuas ntawm cov hmoov tshuaj, yog li ua kom lub zog thiab kev sib zog ntawm cov ntsiav tshuaj zoo dua. Tib lub sijhawm, nws kuj tseem tuaj yeem txhim kho qhov fluidity thiab kev ua haujlwm ntawm cov ntsiav tshuaj, thiab xyuas kom meej qhov sib xws thiab kev ua haujlwm zoo ntawm cov tshuaj.

Raws li ib tug disintegrant

Txawm hais tias HPMC muaj qee qhov viscosity, nws muaj qhov o thiab nqus dej zoo ntawm qib viscosity qis, tuaj yeem nqus cov kua txiv hmab txiv ntoo lossis dej sai sai, thiab txhawb kev tawg ntawm cov ntsiav tshuaj tom qab nthuav dav. Yog li ntawd, HPMC qis-viscosity kuj tseem siv ua cov tshuaj disintegrant hauv kev npaj sai.

Cov khoom siv pob txha uas tswj tau

HPMC tuaj yeem tsim ib txheej gel hauv cov kua dej hauv plab kom txwv tsis pub dej thiab tshuaj sib kis. Yog li ntawd, nws yog siv dav hauv kev npaj cov ntsiav tshuaj tso tawm tas mus li, cov ntsiav tshuaj tswj kev tso tawm thiab lwm yam khoom noj khov kho hauv qhov ncauj. Nws feem ntau siv ua ke nrog lwm cov polymers hydrophilic (xws li PVP, carbomer, thiab lwm yam) los tsim ib lub cev tso tawm tshuaj ruaj khov.

2. Daim ntawv thov ntawm HPMC hauv cov txheej txheem ntsiav tshuaj

HPMC muaj cov yam ntxwv zoo ntawm kev tsim zaj duab xis thiab pob tshab thiab yog ib qho ntawm cov ntaub ntawv siv feem ntau rau kev txheej zaj duab xis ntsiav tshuaj. Piv nrog rau kev txheej qab zib ib txwm muaj lossis txheej polymer yaj hauv dej, zaj duab xis HPMC muaj cov txiaj ntsig zoo li nram no:

Kev tsim zaj duab xis sai, du thiab zoo nkauj;

Kev ua haujlwm tso tawm kho tau;

Kev tiv thaiv zoo rau cov ntsiav tshuaj, noo noo-pov thawj thiab tiv thaiv oxidation;

Siv tau ua ke nrog ntau yam plasticizers (xws li PEG, triacetin, thiab lwm yam) los kho qhov yooj ywm ntawm cov txheej zaj duab xis;

Yaj nyob rau hauv ntau yam tshuaj yaj (dej, ethanol, dej-cawv sib xyaw cov tshuaj yaj, thiab lwm yam), hloov kho tau rau ntau yam txheej txheem npaj.

HPMC txheej feem ntau yog siv los npaj cov txheej enteric, cov txheej tso tawm tas mus li thiab cov txheej tiv thaiv rau kev ua kom zoo nkauj.

3. Daim ntawv thov ntawm HPMC hauv cov tshuaj ntsiav

Cov khoom siv raw ntawm cov tshuaj ntsiav cog

HPMC yog cov cellulose derivative uas tau los ntawm cov nroj tsuag, uas tuaj yeem hloov gelatin ua cov khoom siv tseem ceeb ntawm lub plhaub capsule los ua "tsob nroj tsuag capsules". Piv nrog cov tsiaj gelatin capsules, HPMC capsules muaj cov txiaj ntsig hauv qab no:

Tsis muaj cov khoom xyaw ntawm tsiaj, tsim nyog rau cov neeg tsis noj nqaij thiab cov neeg ntawm kev ntseeg tshwj xeeb;

Kev ruaj khov siab, tsis hnov ​​​​​​mob rau qhov kub thiab txias thiab av noo hloov pauv;

Qis hygroscopicity thiab zoo dua lub zog kho tshuab, ntev lub txee lub neej ntawm cov tshuaj;

Yooj yim rau sau thiab kaw, tsim nyog rau cov khoom siv capsule filling precision.

Cov ntaub ntawv ntim khoom me me uas tswj tau tso tawm

Hauv qee qhov microcapsule tswj kev tso tawm systems, HPMC kuj tseem siv tau ua phab ntsa khoom siv, ua haujlwm ua ke nrog lwm cov polymers kom ua tiav qeeb tso tawm cov tshuaj hauv lub cev los ntawm kev kho qhov tuab thiab tus nqi yaj.

4. Daim ntawv thov ntawm HPMC hauv kev npaj kua

Hauv cov tshuaj qhov muag, cov tshuaj haus thiab cov tshuaj pleev ib ce, HPMC feem ntau siv ua cov khoom tuab, cov khoom ruaj khov thiab cov nplaum:

Cov tshuaj qhov muag: HPMC yog siv los ua cov roj nplua nyeem kom ntev lub sijhawm nyob ntawm cov tshuaj qhov muag rau ntawm qhov chaw ntawm lub qhov muag, txhim kho qhov ua tau zoo ntawm cov tshuaj, thiab txo cov tsos mob ntawm qhov muag qhuav.

Cov tshuaj kua hauv qhov ncauj: ua kom cov kua nplaum ntau ntxiv, txhim kho qhov saj, thiab tiv thaiv kom tsis txhob muaj nag los.

Cov tshuaj pleev ib ce: xws li cov gels, tshuaj pleev, tshuaj pleev, thiab lwm yam, HPMC tuaj yeem txhim kho lawv cov kev ua haujlwm txheej thiab kev nplaum ntawm daim tawv nqaij, thiab txhim kho kev paub ntawm tus neeg siv.

5. Kev nyab xeeb thiab kev pom zoo los ntawm cov koom haum tswj hwm

HPMC yog ib qho tshuaj ntxiv uas tau ntawv pov thawj los ntawm FDA thiab EU EMA, thiab ua tau raws li cov qauv ntawm ntau yam tshuaj pharmacopoeias (xws li USP, Ph. Eur., JP, thiab lwm yam). Nws muaj tshuaj lom tsawg, biocompatibility zoo, thiab tsis ua rau muaj kev tsis haum tshuaj. Nws yog ib qho tshuaj ntxiv uas paub zoo thiab siv dav hauv kev npaj noj thiab tshuaj pleev.

6. Cov qauv kev loj hlob yav tom ntej

Nrog rau kev nce qib ntawm cov tswv yim tshuaj ntsuab thiab ib puag ncig zoo thiab kev nce qib ntawm kev noj zaub, kev siv HPMC hauv cov tshuaj ntsuab thiab cov tshuaj tswj kev tso tawm tau dav dua. Kev tshawb fawb txog HPMC ua tau zoo (xws li HPMC hloov kho tshwj xeeb) hauv kev tso tawm tshuaj, kev tswj kev tso tawm ntse, thiab lwm yam kuj tseem tab tom ua haujlwm ntau ntxiv, uas yuav txhawb nqa nws daim ntawv thov hauv kev lag luam tshuaj siab.

Ua ib qho multifunctional thiab muaj kev nyab xeeb heevtshuaj ntxiv HPMCua lub luag haujlwm tseem ceeb heev hauv kev lag luam tshuaj. Txij li cov khoom siv tshuaj thiab cov khoom siv txheej txheem mus rau cov khoom siv tso tawm niaj hnub thiab cov khoom siv tshuaj ntsuab, nws daim ntawv thov tau nthuav dav tas li thiab yog ib qho ntawm cov khoom tseem ceeb ntawm kev npaj tshuaj niaj hnub.