Ngwa nke HPMC na ụlọ ọrụ ọgwụ

Hydroxypropyl methylcellulose (HPMC)bụ cellulose ether nke na-abụghị ionic nke e ji polymer cellulose mee site na mgbanwe kemịkalụ. O nwere ezigbo ike ịgbaze, njikọta bio na ihe ndị na-emepụta ihe nkiri. N'ihi nchekwa dị elu ya na obere nsí, a na-ejikarị ya eme ihe n'ụlọ ọrụ ọgwụ dị ka ihe na-enye mbadamba ihe, ihe na-adịgide adịgide, ihe mkpuchi, ihe mkpuchi kapsụl, wdg, ma na-arụ ọrụ dị mkpa na nkwadebe siri ike, nkwadebe mmiri mmiri na nkwadebe mwepụta a na-achịkwa.

1. Itinye HPMC n'ime mbadamba

Dị ka ihe njide

Mgbe ejiri HPMC mee ihe dị ka ihe na-ejikọ na mbadamba, a na-agbakwụnye ya n'ụdị mmiri mmiri ma ọ bụ mmiri mmanya, nke nwere ike ime ka ike njikọ dị n'etiti ntụ ọgwụ dịkwuo mma, si otú a na-eme ka ike na mgbochi nrụgide nke mbadamba dịkwuo elu. N'otu oge ahụ, ọ nwekwara ike ime ka arụmọrụ mbadamba na arụmọrụ mbadamba dịkwuo mma, ma hụ na nkwadebe ndị ahụ dị n'otu na ịdị mma nke ihe e ji akpụ ihe.

Dị ka onye na-agbawa agbawa

Ọ bụ ezie na HPMC nwere ụfọdụ viscosity, ọ na-enwe ezigbo ọzịza na mmiri na-amịkọrọ na obere viscosity, ọ nwere ike ịmịkọrọ mmiri ma ọ bụ mmiri afọ ngwa ngwa, ma kwalite mmebi mbadamba mgbe ọ gbasaara. Ya mere, a na-ejikarị HPMC dị obere viscosity eme ihe dị ka ihe na-emebi ihe na nkwadebe ndị na-ewepụta ngwa ngwa.

Ihe ọkpụkpụ a na-achịkwa nke a na-ewepụta

HPMC nwere ike ịmepụta oyi akwa gel n'ime mmiri afọ iji belata ọsọ mgbasa nke mmiri na ọgwụ. Ya mere, a na-ejikarị ya eme ihe n'ịkwadebe mbadamba ndị na-adịgide adịgide, mbadamba ndị a na-achịkwa na nkwadebe siri ike ndị ọzọ a na-aṅụ. A na-ejikarị ya eme ihe na njikọta ya na polymer ndị ọzọ na-emepụta hydrophilic (dịka PVP, carbomer, wdg) iji mepụta usoro ọkpụkpụ nke na-ewepụta ọgwụ siri ike.

2. Ngwa nke HPMC na mkpuchi mbadamba

HPMC nwere ezigbo ihe eji emepụta ihe nkiri na nghọta doro anya, ọ bụkwa otu n'ime ihe ndị a na-ejikarị eme ihe maka mkpuchi ihe nkiri mbadamba. Ma e jiri ya tụnyere mkpuchi shuga ọdịnala ma ọ bụ mkpuchi polymer nke mmiri na-agbaze, ihe nkiri HPMC nwere uru ndị a:

Nhazi ihe nkiri ngwa ngwa, dị ire ụtọ ma mara mma;

Arụmọrụ ntọhapụ a na-agbanwe agbanwe;

Ezigbo nchekwa maka mbadamba, mmiri na-egbochi ma na-egbochi oxidation;

Enwere ike iji ya na ọtụtụ ihe eji eme plastik (dịka PEG, triacetin, wdg) iji gbanwee mgbanwe nke oyi akwa ihe nkiri ahụ;

A na-agbaze n'ọtụtụ ihe mgbaze (mmiri, ethanol, ihe mgbaze agwakọtara na mmanya, wdg), a na-agbanwe agbanwe maka usoro nkwadebe dị iche iche.

A na-ejikarị mkpuchi HPMC eme ihe iji kwadebe mkpuchi enteric, mkpuchi na-adịgide adịgide na mkpuchi nchebe maka ịma mma.

3. Itinye HPMC n'ime kapsụl

Ihe eji emepụta kapsụl osisi

HPMC bụ ihe sitere na cellulose nke sitere na osisi, nke nwere ike dochie gelatin dị ka ihe bụ isi e ji mee kapsụl mee "kapsụl osisi". Ma e jiri ya tụnyere kapsụl gelatin anụmanụ, kapsụl HPMC nwere uru ndị a:

Enweghị ihe e ji anụmanụ mee, nke dabara adaba maka ndị anaghị eri anụ na ndị nwere okpukpe ụfọdụ;

Nkwụsi ike dị elu, enweghị mmetụta maka mgbanwe okpomọkụ na iru mmiri;

Mbelata hygroscopicity na ike igwe ka mma, na-agbatị ndụ nchekwa nke ọgwụ;

Mfe ijupụta na imechi, ọ dị mma maka ngwa njupụta kapsụl dị elu.

Ihe mkpuchi microcapsule a na-achịkwa

N'ụfọdụ sistemụ mwepụta microcapsule a na-achịkwa, enwere ike iji HPMC mee ihe dị ka ihe mgbidi, na-arụkọ ọrụ ọnụ na polymer ndị ọzọ iji nweta mwepụta ọgwụ n'ahụ nwayọ site na ịgbanwe ọkpụrụkpụ na ọnụego mgbasa.

4. Itinye HPMC n'ọrụ n'ime nkwadebe mmiri mmiri

N'ime mmiri anya, ihe ngwọta ọnụ na nkwadebe dị n'elu, a na-ejikarị HPMC eme ihe dị ka ihe na-eme ka ihe sie ike, ihe na-eme ka ihe sie ike na ihe na-arapara:

Ọgwụ anya: A na-eji HPMC eme ihe dị ka mmanụ iji mee ka oge mmiri anya na-adịru n'elu cornea dịkwuo mma, melite irè nke ọgwụ ahụ, ma belata ihe mgbaàmà anya kpọrọ nkụ.

Ọgwụ mmiri ọnụ: mee ka mmiri ahụ dị nro, mee ka uto ya ka mma, ma gbochie mmiri ozuzo.

Nkwadebe ndị dị n'elu: dịka gels, ude mmanụ, ude, wdg., HPMC nwere ike ime ka arụmọrụ mkpuchi ha na nrapado akpụkpọ ahụ ka mma, ma mee ka ahụmịhe onye ọrụ ka mma.

5. Nkwado nchekwa na iwu

HPMC bụ ihe na-enye ọgwụ nke FDA na EU EMA kwadoro, ọ na-emezukwa ụkpụrụ nke ọgwụ dị iche iche (dịka USP, Ph. Eur., JP, wdg). Ọ nwere obere nsí, ezigbo biocompatibility, ọ naghịkwa akpata mmeghachi omume nfụkasị ahụ. Ọ bụ ihe na-enye ọgwụ nchekwa a maara nke ọma, a na-ejikwa ya nke ọma n'ọgwụ a na-aṅụ na nke a na-ete n'elu.

6. Usoro mmepe n'ọdịnihu

Site na mmụba nke echiche ọgwụ ndụ ndụ na gburugburu ebe obibi na mmụba nke enweghị nri, atụmanya ojiji nke HPMC na kapsụl osisi na nkwadebe mwepụta a na-achịkwa achịkwa sara mbara. Nnyocha gbasara HPMC dị elu (dịka HPMC pụrụ iche agbanwere) na mwepụta ọgwụ ezubere iche, mwepụta a na-achịkwa nke ọma, wdg. na-aghọkwa ihe na-arụ ọrụ nke ọma, nke ga-akwalite ojiji ya n'ọhịa nke ọgwụ ndị dị elu.

Dị ka multifunctional na nke dị oke nchebeihe na-enye ọgwụ HPMCna-arụ ọrụ dị oke mkpa n'ụlọ ọrụ ọgwụ. Site na ihe ndị na-enye aka na ihe mkpuchi ọdịnala ruo na ihe ndị na-ebupụta ntọhapụ ọgbara ọhụrụ na ihe ndị e ji osisi mee, ojiji ya na-agbasa mgbe niile ma bụrụkwa otu n'ime ihe ndị dị mkpa maka nkwadebe ọgwụ ọgbara ọhụrụ.