Daim ntawv thov ntawm Hydroxypropyl Methylcellulose (HPMC) ua ib qho tshuaj Excipient hauv Kev Npaj

1. Physicochemical zog ntawm HPMC

HPMC yog cov khoom siv hluavtaws semi-synthetic tau los ntawm methylating thiab hydroxypropylating natural cellulose, nrog rau cov dej solubility zoo thiab biocompatibility. Nws solubility tsis tshua muaj kev cuam tshuam los ntawm qhov kub thiab txias pH, thiab nws tuaj yeem o hauv dej los tsim cov kua dej khov, uas pab tswj cov tshuaj tso tawm. Raws li cov viscosity, HPMC tuaj yeem muab faib ua peb pawg: tsawg viscosity (5-100 mPa·s), nruab nrab viscosity (100-4000 mPa·s) thiab siab viscosity (4000-100000 mPa·s), uas tsim nyog rau kev npaj sib txawv.

2. Kev siv HPMC hauv kev npaj tshuaj

2.1 Daim ntawv thov hauv cov ntsiav tshuaj
HPMC tuaj yeem siv los ua cov khoom sib txuas, cov khoom sib cais, cov khoom siv txheej thiab cov khoom siv pob txha tawm hauv cov ntsiav tshuaj.
Binder:HPMC tuaj yeem siv los ua cov ntaub qhwv hauv cov ntaub ntub dej lossis cov granulation qhuav los txhim kho particle zog, cov ntsiav tshuaj hardness thiab kev ruaj ntseg ntawm cov tshuaj.
Disintegrant:Tsawg-viscosity HPMC tuaj yeem siv los ua cov tshuaj tua kab mob los txhawb cov ntsiav tshuaj disintegration thiab ua kom cov tshuaj yaj tawm tom qab o vim kev nqus dej.
Txheej khoom:HPMC yog ib qho ntawm cov ntaub ntawv tseem ceeb rau cov ntsiav tshuaj txheej, uas tuaj yeem txhim kho cov tsos mob ntawm cov tshuaj, npog qhov tsis zoo ntawm cov tshuaj, thiab tuaj yeem siv rau hauv cov txheej txheej enteric lossis zaj duab xis txheej nrog plasticizers.
Tswj-tso cov ntaub ntawv: High-viscosity HPMC tuaj yeem siv los ua cov khoom siv pob txha kom ncua kev tso tshuaj thiab ua tiav kev tso tawm lossis tswj tau. Piv txwv li, HPMC K4M, HPMC K15M thiab HPMC K100M feem ntau siv los npaj cov ntsiav tshuaj tswj-tso.

2.2 Daim ntawv thov hauv kev npaj tshuaj ntsiav
HPMC tuaj yeem siv los tsim cov tshuaj cog qoob loo los hloov cov gelatin capsules, uas tsim nyog rau cov neeg tsis noj nqaij thiab cov neeg uas tsis haum rau tsiaj los ntawm cov tshuaj ntsiav. Tsis tas li ntawd, HPMC tuaj yeem siv rau kev ntim cov kua lossis semisolid capsules los txhim kho kev ruaj ntseg thiab tso tawm cov yam ntxwv ntawm cov tshuaj.

2.3 Daim ntawv thov hauv kev npaj kho qhov muag
HPMC, raws li lub ntsiab lus tseem ceeb ntawm cov kua muag dag, tuaj yeem ua kom cov viscosity ntawm qhov muag te, ua kom lub sijhawm nyob ntawm cov tshuaj nyob rau ntawm lub qhov muag, thiab txhim kho bioavailability. Tsis tas li ntawd, HPMC kuj tuaj yeem siv los npaj qhov muag gels, qhov muag cov yeeb yaj kiab, thiab lwm yam, txhawm rau txhim kho cov txiaj ntsig tso tawm ntawm qhov muag tshuaj.

2.4 Daim ntawv thov nyob rau hauv kev npaj xa tshuaj
AnxinCel®HPMC muaj cov cuab yeej ua yeeb yaj kiab zoo thiab biocompatibility, thiab tuaj yeem siv los npaj cov tshuaj pleev ib ce, gels thiab cream. Piv txwv li, hauv kev xa tshuaj transdermal, HPMC tuaj yeem siv los ua cov khoom siv matrix kom nce cov tshuaj nkag mus thiab ua kom ntev ntev ntawm kev ua.