Hydroxypropyl Methylcellulose (HPMC)ne nonionic cellulose ether tare da mai kyau fim-forming, adhesion, thickening da sarrafawa saki Properties, kuma ana amfani da ko'ina a cikin Pharmaceutical masana'antu. A matsayin ƙarin kayan aikin magunguna, ana iya amfani da AnxinCel®HPMC a cikin allunan, capsules, shirye-shiryen ci gaba da ɗorewa, shirye-shiryen ido da tsarin isar da magunguna.
1. Physicochemical Properties na HPMC
HPMC wani Semi-Synthetic polymer abu samu ta methylating da hydroxypropylating halitta cellulose, tare da m ruwa solubility da biocompatibility. Solubility ɗinsa ba shi da tasiri ta yanayin zafi da ƙimar pH, kuma yana iya kumbura a cikin ruwa don samar da bayani mai ɗanɗano, wanda ke taimakawa sarrafa sakin magunguna. Bisa ga danko, HPMC za a iya raba uku Categories: low danko (5-100 mPa · s), matsakaici danko (100-4000 mPa · s) da kuma high danko (4000-100000 mPa · s), wanda dace da daban-daban shirye-shirye bukatun.
2. Aikace-aikacen HPMC a cikin shirye-shiryen magunguna
2.1 Aikace-aikace a cikin allunan
Ana iya amfani da HPMC azaman ɗaure, tarwatsewa, kayan shafa da kayan kwarangwal mai sarrafawa a cikin allunan.
Mai ɗaure:HPMC za a iya amfani da a matsayin mai ɗaure a rigar granulation ko bushe granulation don inganta barbashi ƙarfi, kwamfutar hannu taurin da inji kwanciyar hankali na kwayoyi.
Mai rushewa:Ana iya amfani da HPMC mai ƙarancin danko azaman mai tarwatsewa don haɓaka rarrabuwar kwamfutar hannu da haɓaka ƙimar narkar da ƙwayoyi bayan kumburi saboda shayar da ruwa.
Kayan shafa:HPMC yana daya daga cikin manyan kayan da ake amfani da su don gyaran fuska na kwamfutar hannu, wanda zai iya inganta bayyanar kwayoyi, rufe mummunan dandano na kwayoyi, kuma za'a iya amfani dashi a cikin suturar ciki ko fim din tare da filastik.
Abun da aka sarrafa-saki: Ana iya amfani da HPMC mai girman danko azaman kayan kwarangwal don jinkirta sakin magani da samun ci gaba ko sarrafawa mai sarrafawa. Misali, HPMC K4M, HPMC K15M da HPMC K100M galibi ana amfani dasu don shirya allunan da aka sarrafa sarrafawa.
2.2 Aikace-aikace a cikin shirye-shiryen capsule
Ana iya amfani da HPMC don samar da capsules mara kyau da aka samo daga shuka don maye gurbin capsules na gelatin, wanda ya dace da masu cin ganyayyaki da mutanen da ke rashin lafiyar capsules na dabba. Bugu da kari, ana iya amfani da HPMC don cika ruwa ko capsules mai ƙarfi don haɓaka kwanciyar hankali da halayen sakin magunguna.
2.3 Aikace-aikace a cikin shirye-shiryen ido
HPMC, a matsayin babban ɓangaren hawaye na wucin gadi, na iya ƙara dankon ido na ido, tsawaita lokacin zama na magunguna a saman ido, da inganta yanayin rayuwa. Bugu da kari, HPMC kuma za a iya amfani da su shirya ido gels, ido films, da dai sauransu, don inganta ci gaba da saki sakamakon ido magunguna.
2.4 Aikace-aikace a cikin shirye-shiryen isar da magunguna
AnxinCel®HPMC yana da kyawawan kaddarorin samar da fina-finai da daidaituwa, kuma ana iya amfani da su don shirya faci, gels da creams. Misali, a cikin tsarin isar da magunguna ta transdermal, ana iya amfani da HPMC azaman kayan matrix don haɓaka ƙimar shigar da miyagun ƙwayoyi da tsawaita lokacin aiki.
2.5 Aikace-aikace a cikin ruwa na baka da dakatarwa
HPMC za a iya amfani da a matsayin thickener da stabilizer don inganta rheological Properties na baka ruwa da kuma dakatar, hana m barbashi daga daidaitawa, da kuma inganta uniformity da kwanciyar hankali na kwayoyi.
2.6 Aikace-aikace a cikin shirye-shiryen inhalation
Ana iya amfani da HPMC azaman mai ɗaukar hoto don busassun foda (DPI) don haɓaka haɓakar ruwa da rarrabuwar ƙwayoyi, haɓaka ƙimar ƙwayar huhu na ƙwayoyin cuta, don haka haɓaka tasirin warkewa.
3. Abũbuwan amfãni daga HPMC a ci gaba-saki shirye-shirye
HPMC yana da halaye masu zuwa a matsayin ci gaba mai ɗorewa-saki:
Kyakkyawan narkewar ruwa:Yana iya sauri kumbura cikin ruwa don samar da shingen gel da daidaita yawan sakin miyagun ƙwayoyi.
Kyakkyawan bioacompatibility:ba mai guba ba kuma ba mai fushi ba, ba a shayar da jikin mutum ba, kuma yana da hanyar rayuwa mai tsabta.
Ƙarfin daidaitawa:Ya dace da nau'ikan magunguna daban-daban, gami da masu narkewar ruwa da magungunan hydrophobic.
Tsari mai sauƙi:Ya dace da matakai daban-daban na shirye-shiryen irin su tableting kai tsaye da rigar granulation.
A matsayin mahimmancin kayan aikin magunguna,HPMCana amfani da shi sosai a fannoni da yawa kamar allunan, capsules, shirye-shiryen ido, shirye-shirye na Topical, da sauransu, musamman a cikin shirye-shiryen ci gaba-saki. A nan gaba, tare da ci gaba da haɓaka fasahar shirye-shiryen harhada magunguna, za a ƙara faɗaɗa iyakar aikace-aikacen AnxinCel®HPMC, tare da samar da masana'antar harhada magunguna tare da ingantattun zaɓuɓɓukan haɓakawa masu aminci.
Lokacin aikawa: Fabrairu-08-2025