1. I-Crosscarmellose sodium(i-CMCNa exhumene ne-cross-linked): i-copolymer exhumene ne-cross-linked ye-CMCNa
Izakhiwo: Impuphu emhlophe noma engemhlophe nhlobo. Ngenxa yesakhiwo esixhumene, ayincibiliki emanzini; ivuvukala ngokushesha emanzini kuze kube ngumthamo wayo wokuqala ophindwe ka-4-8. Impuphu inomswakama omuhle.
Ukusetshenziswa: Yiyona evame ukusetshenziswa kakhulu i-super disintegrant. I-Disintegrant yamaphilisi omlomo, ama-capsule, ama-granules.
2. I-Carmelose calcium (i-CMCCa exhumene ne-cross-linked):
Izakhiwo: Impuphu emhlophe, engenaphunga, i-hygroscopic. Isixazululo esingu-1% pH 4.5-6. Cishe ayincibiliki ku-ethanol kanye ne-ether solvent, ayincibiliki emanzini, ayincibiliki ku-hydrochloric acid encibilikisiwe, incibilika kancane ku-alkali encibilikisiwe. noma kumpuphu omhlophe ongacwebezeli. Ngenxa yesakhiwo esixhumene, ayincibiliki emanzini; iyavuvukala uma imunca amanzi.
Isicelo: ithebhulethi ehlukanisiwe, i-binder, i-diluent.
3. I-Methylcellulose (MC):
Isakhiwo: i-methyl ether ye-cellulose
Izakhiwo: Impuphu emhlophe noma ama-granule amhlophe kuya kophuzi. Ayincibiliki emanzini ashisayo, isixazululo sikasawoti esigcwele, i-alcohol, i-ether, i-acetone, i-toluene, i-chloroform; incibilika ku-glacial acetic acid noma ingxube elinganayo yotshwala ne-chloroform. Ukuncibilika emanzini abandayo kuhlobene nezinga lokushintsha, futhi incibilika kakhulu uma izinga lokushintsha lingu-2.
Ukusetshenziswa: i-tablet binder, i-matrix ye-tablet disintegrating agent noma ukulungiswa okuqhubekayo, ukhilimu noma ijeli, i-suspension agent kanye ne-thickening agent, i-tablet coating, i-emulsion stabilizer.
4. I-Ethyl cellulose (EC):
Isakhiwo: I-ethyl ether ye-cellulose
Izakhiwo: Impuphu emhlophe noma ephuzi-mhlophe kanye nama-granule. Ayincibiliki emanzini, uketshezi lwesisu, i-glycerol kanye ne-propylene glycol. Incibilika kalula ku-chloroform kanye ne-toluene, futhi yakha i-white precipitate uma kwenzeka i-ethanol.
Ukusetshenziswa: Into efanelekile yokuthwala engancibiliki emanzini, efanelekile njenge-matrix yemithi ezwela amanzi, into ethwala engancibiliki emanzini, i-tablet binder, into yefilimu, into ye-microcapsule kanye nezinto zokumboza ezikhishwa njalo, njll.
5. I-Hydroxyethyl Cellulose (HEC):
Isakhiwo: I-ether ye-hydroxyethyl engaphelele ye-cellulose.
Izakhiwo: Impuphu ephuzi kancane noma emhlophe njengobisi. Incibilika ngokuphelele emanzini abandayo, emanzini ashisayo, i-asidi ebuthakathaka, isisekelo esibuthakathaka, i-asidi eqinile, isisekelo esiqinile, engancibiliki ezincibilikisini eziningi zezinto eziphilayo (encibilika ku-dimethyl sulfoxide, i-dimethylformamide), ezincibilikisini zezinto eziphilayo ze-diol polar Inganwebeka noma incibilike kancane.
Izicelo: Izinto ze-polymer ezingezona i-ionic ezincibilika emanzini; izithambisi zokulungiselela amehlo, i-otology kanye nokusetshenziswa kwangaphandle; i-HEC ezintweni zokugcoba amehlo omile, ama-contact lens kanye nomlomo owomile; isetshenziswa ezimonyweni. Njenge-binder, i-ejenti yokwakha ifilimu, i-ejenti yokuqina, i-ejenti yokumisa kanye ne-stabilizer yemithi nokudla, ingahlanganisa izinhlayiya zemithi, ukuze izinhlayiya zemithi zidlale indima yokukhulula kancane.
6. I-Hydroxypropyl Cellulose (HPC):
Isakhiwo: I-ether ye-polyhydroxypropyl engaphelele ye-cellulose
Izakhiwo: I-HPC efakwe esikhundleni esiphezulu imhlophe noma iphuzi kancane. Incibilika ku-methanol, i-ethanol, i-propylene glycol, i-isopropanol, i-dimethyl sulfoxide kanye ne-dimethyl formamide, inguqulo ephezulu ye-viscosity ayincibiliki kakhulu. Ayincibiliki emanzini ashisayo, kodwa ingavuvukala. I-gelation eshisayo: incibilika kalula emanzini angaphansi kuka-38°C, i-gelatinized ngokushisa, futhi yakha ukuvuvukala kwe-flocculent ku-40-45°C, okungabuyiselwa ngokupholisa.
Izici ezivelele ze-L-HPC: ezingancibiliki emanzini nasezincibilikisini eziphilayo, kodwa ziyavuvukala emanzini, futhi isici sokuvuvukala siyanda ngokwanda kwezinto ezithatha indawo.
Ukusetshenziswa: I-HPC efakwe esikhundleni esiphezulu isetshenziswa njenge-tablet binder, i-granulating agent, izinto zokumboza ifilimu, futhi ingasetshenziswa njengezinto zefilimu ezincane ezifakwe emaphaketheni, izinto ze-matrix kanye nezinto ezisizayo zethebhulethi yokugcina isisu, i-thickener kanye ne-Protective colloids, ezivame ukusetshenziswa kuma-patches e-transdermal.
I-L-HPC: Isetshenziswa kakhulu njenge-tablet disintegrant noma i-binder ye-wet granulation, njenge-matrix yethebhulethi ekhishwa njalo, njll.
7. I-Hypromellose (HPMC):
Isakhiwo: I-methyl engaphelele kanye ne-polyhydroxypropyl ether ye-cellulose
Izakhiwo: Impuphu emhlophe noma engeyona emhlophe noma e-granular. Iyancibilika emanzini abandayo, ayincibiliki emanzini ashisayo, futhi inezakhiwo ze-thermal gelation. Iyancibilika ezixazululweni ze-methanol ne-ethanol, ama-hydrocarbon ane-chlorine, i-acetone, njll. Ukuncibilika kwayo ezixazululweni zezinto eziphilayo kungcono kunokuncibilika emanzini.
Ukusetshenziswa: Lo mkhiqizo uyisisombululo samanzi esinomfutho ophansi esisetshenziswa njengento yokumboza ifilimu; isisombululo se-organic solvent esinomfutho ophakeme sisetshenziswa njenge-tablet binder, kanti umkhiqizo onomfutho ophakeme ungasetshenziswa ukuvimba i-matrix yokukhululwa kwemithi encibilikayo emanzini; njengesithambisi samaconsi amehlo se-lacquer kanye ne-artificial drumb, kanye ne-wetting agent yama-contact lens.
8. I-Hypromellose Phthalate (HPMCP):
Isakhiwo: I-HPMCP iyi-phthalic acid half ester ye-HPMC.
Izakhiwo: Ama-flakes noma ama-granule anombala o-beige noma amhlophe. Angancibiliki emanzini nasesisombululo se-asidi, awancibiliki ku-hexane, kodwa ancibilika kalula engxubeni ye-acetone:methanol, i-acetone:ethanol noma i-methanol:chloromethane.
Ukusetshenziswa: Uhlobo olusha lwezinto zokumboza ezisebenza kahle kakhulu, ezingasetshenziswa njengembozo yefilimu ukufihla iphunga elingavamile lamaphilisi noma ama-granule.
9. I-Hypromellose Acetate Succinate (i-HPMCAS):
Isakhiwo: Ama-ester axubile e-acetic kanye nama-succinicI-HPMC
Izakhiwo: Impuphu emhlophe noma ama-granule amhlophe kuya kophuzi. Incibilika kusisombululo se-sodium hydroxide kanye ne-sodium carbonate, incibilika kalula ku-acetone, i-methanol noma i-ethanol: amanzi, ingxube ye-dichloromethane: ethanol, ayincibiliki emanzini, i-ethanol kanye ne-ether.
Isicelo: Njengezinto zokugqoka ze-enteric zethebhulethi, izinto zokugqoka ezikhishwa njalo kanye nezinto zokugqoka zefilimu.
10. I-Agar:
Isakhiwo: I-Agar iyinhlanganisela yama-polysaccharide okungenani amabili, cishe i-agarose engathathi hlangothi engu-60-80% kanye ne-agarose engu-20-40%. I-Agarose yakhiwe ngamayunithi aphindaphindayo e-agarobiose lapho i-D-galactopyranosose kanye ne-L-galactopyranosose zixhunyaniswa khona ngokushintshana ku-1-3 kanye no-1-4.
Izakhiwo: I-Agar inombala okhanyayo, iyisilinda esiyisikwele esiphuzi esikhanyayo, umucu omncane noma i-scaly flake noma into efana nempuphu. Ayincibiliki emanzini abandayo, incibilika emanzini abilayo. Ivuvukala izikhathi ezingu-20 emanzini abandayo.
Ukusetshenziswa: Njenge-ejenti yokubopha, isisekelo samafutha, isisekelo se-suppository, i-emulsifier, i-stabilizer, i-ejenti yokumisa, futhi njenge-poultice, i-capsule, isiraphu, i-jelly kanye ne-emulsion.
Isikhathi sokuthunyelwe: Ephreli-26-2024