1. Sodium Croscarmellose(CMCNa-isku xiran): kopolymer isku xiran oo CMCNa ah
Sifooyinka: Budada cad ama cad. Sababtoo ah qaab-dhismeedka isku-xidhan, kuma milmi karo biyaha; si degdeg ah ayuu ugu bararaa biyaha ilaa 4-8 jeer muggiisii asalka ahaa. Budadu waxay leedahay dareere wanaagsan.
Adeegsiga: Waa daawada ugu badan ee loo isticmaalo nadiifinta. Daawada loogu talagalay kiniiniyada afka laga qaato, kaabsulka, iyo granules-ka.
2. Kaalshiyam Carmellose (CMCCa-isku xiran):
Sifooyinka: Budo cad, aan ur lahayn, hygroscopic. 1% xal pH 4.5-6. Ku dhawaad aan ku milmin ethanol iyo dareeraha ether, aan ku milmin biyaha, aan ku milmin aashitada hydrochloric-ka ee khafiifka ah, oo si yar ugu milmi karta alkali khafiif ah ama budada cad. Sababtoo ah qaab-dhismeedka isku-xidhka ah, kuma milmi karo biyaha; wuu bararaa marka uu nuugo biyaha.
Codsiga: Kiniiniga kala firdhiya, xidhmo, dareere.
3. Methylcellulose (MC):
Qaab-dhismeedka: methyl ether ee cellulose
Sifooyinka: Budada cad ama budada cad ilaa jaalle. Aan ku milmin biyaha kulul, xalka cusbada buuxa, khamriga, ether, acetone, toluene, chloroform; ku milmi kara aashitada glacial acetic ama isku darka isku midka ah ee khamriga iyo chloroform. Milmida biyaha qabow waxay la xiriirtaa heerka beddelka, waana mid aad u milmi karta marka heerka beddelka uu yahay 2.
Codsiga: xabagta kiniinka, shaxda wakiilka kala-baxa kiniinka ama diyaarinta sii-deynta joogtada ah, kareem ama jel, wakiilka joojinta iyo wakiilka dhumucda, dahaarka kiniinka, xasiliyaha emulsion-ka.
4. Ethyl cellulose (EC):
Qaab-dhismeedka: Ethyl ether ee cellulose
Sifooyinka: Budada cad ama jaalle-cad iyo granules. Kuma milmi karo biyaha, dareeraha caloosha iyo mindhicirka, glycerol iyo propylene glycol. Si fudud ayuu ugu milmi karaa chloroform iyo toluene, wuxuuna sameeyaa soo-saar cad haddii ethanol la helo.
Adeegsiga: Qalab side biyo-la'aan ah oo ku habboon, oo ku habboon sida matrix daawo oo xasaasiyad ku leh biyaha, side biyo-la'aan ah, xabag kiniin, walxo filim, walxo microcapsule ah iyo walxo dahaar sii-deyn ah oo joogto ah, iwm.
5. Hydroxyethyl Cellulose (HEC):
Qaab-dhismeedka: Qayb ka mid ah hydroxyethyl ether ee cellulose.
Sifooyinka: Budada jaalaha ah ee khafiifka ah ama caanaha leh. Si buuxda ugu milma biyaha qabow, biyaha kulul, aashitada daciifka ah, saldhig daciif ah, aashitada xooggan, saldhig xooggan, aan ku milmi karin inta badan dareerayaasha dabiiciga ah (ku milma dimethyl sulfoxide, dimethylformamide), dareerayaasha dabiiciga ah ee diol polar. Waxay ballaarin karaan ama qayb ahaan u milmi karaan.
Adeegsiga: Alaabada polymer-ka ee aan biyaha ku milmin ee aan ionic ahayn; dhumuc-sameeyayaasha loogu talagalay diyaarinta indhaha, daaweynta indhaha iyo isticmaalka maqaarka; HEC ee saliidaha indhaha qalalan, muraayadaha indhaha iyo afka qalalan; loo isticmaalo qurxinta. Sida xidhmo, wakiil sameeya filim, wakiil dhumuc-sameeye, wakiil joojiya iyo xasiliya daawooyinka iyo cuntada, waxay ku duubi kartaa walxaha daawada, si walxaha daawada ay u ciyaaraan door si tartiib tartiib ah u sii daaya.
6. Hydroxypropyl Cellulose (HPC):
Qaab-dhismeedka: Qayb ka mid ah polyhydroxypropyl ether ee cellulose
Sifooyinka: HPC-ga oo aad loo beddelay waa budo cad ama huruud yar. Waxaa lagu milmi karaa methanol, ethanol, propylene glycol, isopropanol, dimethyl sulfoxide iyo dimethyl formamide, nooca viscosity-ga sare ma milmi karo. Kuma milmi karo biyaha kulul, laakiin wuu barari karaa. Gelitaanka kulaylka: si fudud ayuu ugu milmi karaa biyaha ka hooseeya 38°C, waxaa lagu shiiday kuleyl, wuxuuna sameeyaa barar dabacsan oo ah 40-45°C, kaas oo lagu soo celin karo qaboojinta.
Astaamaha cajiibka ah ee L-HPC: aan ku milmin biyaha iyo dareerayaasha dabiiciga ah, laakiin ku milmi kara biyaha, iyo hantida bararka ayaa kordha marka ay kordhaan walxaha beddelka ah
Codsiga: HPC-ga oo si heer sare ah loo beddelay waxaa loo isticmaalaa sidii xabag kiniin ah, wakiil granulating ah, walxo dahaarka filimka ah, waxaana sidoo kale loo isticmaali karaa sida walxo filim ah oo yar yar, walxo matrix ah iyo walxo kaabayaal ah oo kiniinka xajinta caloosha ah, dhumuc-dhejin iyo colloids-ka ilaalinta, oo sidoo kale si caadi ah loogu isticmaalo balastarrada maqaarka.
L-HPC: Inta badan waxaa loo isticmaalaa sidii kiniin kala firdhiya ama xidhe loogu talagalay granulation-ka qoyan, sida matrix kiniin ah oo sii daaya oo joogto ah, iwm.
7. Hypromellose (HPMC):
Qaab-dhismeedka: Qayb ahaan methyl iyo qayb ahaan polyhydroxypropyl ether oo cellulose ah
Sifooyinka: Budada cad ama cad ee fiilooyinka leh ama granular. Waa mid ku milma biyaha qabow, kuma milma biyaha kulul, waxayna leedahay sifooyin jeleynta kulaylka. Waa mid ku milma methanol iyo ethanol, hydrocarbons chlorine ah, acetone, iwm. Ku milma dareeraha dabiiciga ah ayaa ka wanaagsan biyaha ku milma.
Adeegsiga: Badeecadani waa xal biyood oo jilicsan oo loo isticmaalo sidii walxo dahaar filim ah; xal dareere dabiici ah oo jilicsan oo jilicsan ayaa loo isticmaalaa sidii xabag kiniin ah, badeecada nuugista sare lehna waxaa loo isticmaali karaa in lagu xannibo matrix-ka sii daaya ee daawooyinka biyaha ku milma; sida dhibcooyinka indhaha oo dhumuc weyn u leh lacquer-ka iyo ilmada macmalka ah, iyo wakiilka qoynta ee muraayadaha taabashada.
8. Hypromellose Phthalate (HPMCP):
Qaab-dhismeedka: HPMCP waa ester-ka nus-ka ah ee aashitada phthalic ee HPMC.
Sifooyinka: Buluug ama jajab cad ama granules. Ku milmi karin biyaha iyo xalka aashitada, ku milmi karin hexane, laakiin si fudud ugu milmi kara isku darka acetone: methanol, acetone: ethanol ama methanol: chloromethane.
Adeegsiga: Nooc cusub oo ah walxo dahaadh ah oo leh waxqabad aad u wanaagsan, kaas oo loo isticmaali karo dahaadh filim si loo qariyo urta gaarka ah ee kiniiniyada ama granules.
9. Hypromellose Acetate Succinate (HPMCAS):
Qaab-dhismeedka: Esters isku dhafan oo acetic iyo succinic ahHPMC
Sifooyinka: Budada cad ama granules cad ilaa huruud. Ku milma sodium hydroxide iyo sodium carbonate, si fudud ugu milma acetone, methanol ama ethanol: biyo, dichloromethane: ethanol isku darka, aan ku milmi karin biyaha, ethanol iyo ether.
Codsiga: Sida kiniin dahaarka enteric, qalab dahaarka sii daynta joogtada ah iyo qalab dahaarka filimka.
10. Agaar:
Qaab-dhismeedka: Agar waa isku-darka ugu yaraan laba polysaccharides, qiyaastii 60-80% agarose dhexdhexaad ah iyo 20-40% agarose. Agarose wuxuu ka kooban yahay unugyo soo noqnoqda oo agarobiose ah oo D-galactopyranosis iyo L-galactopyranosis si isku mid ah ugu xiran yihiin 1-3 iyo 1-4.
Sifooyinka: Agar waa dhululubo laba jibbaaran oo hufan, huruud khafiif ah, xariijin khafiif ah ama jajab qolof leh ama walax budo ah. Kuma milmi karo biyo qabow, kuna milmi karo biyo karkaraya. Waxay ku barari kartaa 20 jeer biyo qabow.
Codsiga: Sida wakiilka xidhitaanka, saldhigga cadarka, saldhigga suppository, emulsifier, stabilizer, wakiilka joojinta, sidoo kale sida poultice, kaabsal, sharoobada, jelly iyo emulsion.
Waqtiga boostada: Abriil-26-2024