1. Sodium ya Croscarmellose(CMCNa yolumikizidwa ndi mtanda): copolymer yolumikizidwa ndi mtanda ya CMCNa
Kapangidwe kake: Ufa woyera kapena wosakhala woyera. Chifukwa cha kapangidwe kake kolumikizidwa, susungunuka m'madzi; umatupa mofulumira m'madzi mpaka kuwirikiza ka 4-8 kuchuluka kwake koyambirira. Ufawo uli ndi madzi okwanira.
Kugwiritsa Ntchito: Ndi mankhwala ofala kwambiri omwe amagwiritsidwa ntchito pochiza matenda a shuga. Mankhwala ofala kwambiri omwe amagwiritsidwa ntchito pakamwa monga mapiritsi, makapisozi, ndi tinthu tating'onoting'ono.
2. Carmelose calcium (CMCCa yolumikizidwa ndi cross-linked):
Kapangidwe kake: Ufa woyera, wopanda fungo, wosasungunuka. 1% yankho pH 4.5-6. Wosasungunuka kwambiri mu ethanol ndi ether solvent, wosasungunuka m'madzi, wosasungunuka mu hydrochloric acid wosungunuka, wosungunuka pang'ono mu alkali wosungunuka. kapena ufa woyera. Chifukwa cha kapangidwe kake kolumikizidwa, susungunuka m'madzi; umatupa ukatenga madzi.
Kugwiritsa ntchito: piritsi losungunuka, chomangira, chosungunula.
3. Methylcellulose (MC):
Kapangidwe: methyl ether ya cellulose
Kapangidwe kake: Ufa woyera mpaka wachikasu woyera kapena granules. Susungunuka m'madzi otentha, madzi okhuta amchere, mowa, ether, acetone, toluene, chloroform; umasungunuka mu glacial acetic acid kapena chisakanizo chofanana cha mowa ndi chloroform. Kusungunuka m'madzi ozizira kumagwirizana ndi kuchuluka kwa kusintha, ndipo kumasungunuka kwambiri ngati kuchuluka kwa kusintha kuli 2.
Kugwiritsa ntchito: chomangira mapiritsi, matrix ya mankhwala osungunuka kapena kukonzekera kotulutsidwa kosatha, kirimu kapena gel, mankhwala oimika ndi othandizira kukhuthala, chophimba mapiritsi, chokhazikika cha emulsion.
4. Ethyl cellulose (EC):
Kapangidwe: Ethyl ether ya cellulose
Kapangidwe kake: Ufa woyera kapena wachikasu-woyera ndi tinthu tating'onoting'ono. Susungunuka m'madzi, m'mimba, glycerol ndi propylene glycol. Umasungunuka mosavuta mu chloroform ndi toluene, ndipo umapanga mpweya woyera ngati uli ndi ethanol.
Kugwiritsa Ntchito: Chonyamulira choyenera chosasungunuka m'madzi, choyenera ngati mankhwala oletsa madzi, chonyamulira chosasungunuka m'madzi, chosungira mapiritsi, zinthu zopangidwa ndi filimu, zinthu zopangidwa ndi microcapsule ndi zinthu zophimba zomwe zimatulutsidwa nthawi zonse, ndi zina zotero.
5. Hydroxyethyl Cellulose (HEC):
Kapangidwe: Etha ya hydroxyethyl ya cellulose.
Makhalidwe: Ufa woyera wachikasu pang'ono kapena wa mkaka. Wosungunuka kwathunthu m'madzi ozizira, madzi otentha, asidi wofooka, maziko ofooka, asidi wamphamvu, maziko olimba, osasungunuka m'zinthu zambiri zachilengedwe (zosungunuka mu dimethyl sulfoxide, dimethylformamide), mu diol polar organic solvents Imatha kufutukuka kapena kusungunuka pang'ono.
Kugwiritsa Ntchito: Zipangizo za polima zosungunuka m'madzi zosagwiritsa ntchito ayoni; zothira mafuta opangira maso, otology ndi kugwiritsa ntchito pakhungu; HEC mu mafuta odzola a maso ouma, magalasi olumikizirana ndi pakamwa pouma; zomwe zimagwiritsidwa ntchito mu zodzoladzola. Monga chomangirira, chopangira filimu, chokhuthala, choyimitsa komanso chokhazikika cha mankhwala ndi chakudya, imatha kuphimba tinthu ta mankhwala, kuti tinthu ta mankhwala tigwire ntchito yotulutsa pang'onopang'ono.
6. Hydroxypropyl Cellulose (HPC):
Kapangidwe: Partial polyhydroxypropyl ether ya cellulose
Katundu: HPC yosinthidwa kwambiri ndi ufa woyera kapena wachikasu pang'ono. Yosungunuka mu methanol, ethanol, propylene glycol, isopropanol, dimethyl sulfoxide ndi dimethyl formamide, mtundu wapamwamba wa viscosity susungunuka kwambiri. Yosasungunuka m'madzi otentha, koma imatha kutupa. Gelation yotentha: Yosungunuka mosavuta m'madzi pansi pa 38°C, yosungunuka ndi gelatin potenthetsera, ndikupanga kutupa kwa flocculent pa 40-45°C, komwe kumatha kubwezeretsedwanso pozizira.
Zinthu zabwino kwambiri za L-HPC: sizisungunuka m'madzi ndi zinthu zachilengedwe zosungunulira, koma zimatha kusungunuka m'madzi, ndipo kutupa kumawonjezeka ndi kuchuluka kwa zinthu zina.
Kugwiritsa Ntchito: HPC yosinthidwa kwambiri imagwiritsidwa ntchito ngati chomangira mapiritsi, chopangira granulating, chophikira filimu, ndipo ingagwiritsidwenso ntchito ngati filimu yokhala ndi microcapsulated, matrix ndi zinthu zothandizira za piritsi losungira m'mimba, chokhuthala ndi ma colloids oteteza, omwe amagwiritsidwanso ntchito kwambiri m'magawo a transdermal.
L-HPC: Amagwiritsidwa ntchito makamaka ngati piritsi losasinthika kapena chomangira chonyowa, ngati matrix ya piritsi yotulutsidwa nthawi zonse, ndi zina zotero.
7. Hypromellose (HPMC):
Kapangidwe: Methyl pang'ono ndi polyhydroxypropyl ether ya cellulose
Kapangidwe kake: Ufa woyera kapena wopanda ulusi kapena granular. Umasungunuka m'madzi ozizira, susungunuka m'madzi otentha, ndipo uli ndi kapangidwe ka kutentha. Umasungunuka mu methanol ndi ethanol solutions, chlorinated hydrocarbons, acetone, ndi zina zotero. Kusungunuka kwake mu organic solvents ndikwabwino kuposa kusungunuka m'madzi.
Kugwiritsa Ntchito: Chogulitsachi ndi madzi otsika kukhuthala omwe amagwiritsidwa ntchito ngati zinthu zokutira filimu; njira yosungunulira yachilengedwe yokhuthala kwambiri imagwiritsidwa ntchito ngati chomangira mapiritsi, ndipo chinthu chokhuthala kwambiri chingagwiritsidwe ntchito kuletsa kutulutsa kwa mankhwala osungunuka m'madzi; monga chokhuthala cha madontho a maso cha lacquer ndi misozi yopangira, komanso chonyowetsa magalasi olumikizirana.
8. Hypromellose Phthalate (HPMCP):
Kapangidwe: HPMCP ndi theka la ester ya phthalic acid ya HPMC.
Kapangidwe kake: Zidutswa za beige kapena zoyera kapena tinthu tating'onoting'ono. Sizimasungunuka m'madzi ndi asidi, sizisungunuka mu hexane, koma zimasungunuka mosavuta mu acetone:methanol, acetone:ethanol kapena methanol:chloromethane.
Kugwiritsa Ntchito: Mtundu watsopano wa zinthu zokutira zomwe zimagwira ntchito bwino kwambiri, zomwe zingagwiritsidwe ntchito ngati zokutira filimu kuti zibise fungo lapadera la mapiritsi kapena tinthu tating'onoting'ono.
9. Hypromellose Acetate Succinate (HPMCAS):
Kapangidwe: Ma ester osakaniza a acetic ndi succinic aHPMC
Kapangidwe kake: Ufa woyera kapena tinthu tating'onoting'ono toyera mpaka chikasu. Sungunuka mu sodium hydroxide ndi sodium carbonate solution, umasungunuka mosavuta mu acetone, methanol kapena ethanol:madzi, dichloromethane:ethanol mixture, susungunuka m'madzi, ethanol ndi ether.
Kugwiritsa Ntchito: Monga zinthu zopangira piritsi, zinthu zopangira zotulutsa zokhazikika komanso zinthu zopangira filimu.
10. Agari:
Kapangidwe: Agar ndi chisakanizo cha ma polysaccharide osachepera awiri, pafupifupi 60-80% agarose yopanda mbali ndi 20-40% agarose. Agarose imapangidwa ndi mayunitsi obwerezabwereza a agarobiose momwe D-galactopyranosose ndi L-galactopyranosose zimalumikizidwa motsatizana pa 1-3 ndi 1-4.
Kapangidwe kake: Agar ndi wowala, wachikasu wopepuka, wopyapyala kapena wooneka ngati scaly flake kapena ufa. Wosasungunuka m'madzi ozizira, wosungunuka m'madzi otentha. Amatupa ka 20 m'madzi ozizira.
Kugwiritsa ntchito: Monga chomangira, maziko a mafuta, maziko a suppository, emulsifier, stabilizer, chomangirira, komanso ngati nthunzi, kapisozi, madzi, jelly ndi emulsion.
Nthawi yotumizira: Epulo-26-2024