1. Croscarmellose sodium(cross-linked CMCNa): ib qho copolymer cross-linked ntawm CMCNa
Cov Khoom: Hmoov dawb los yog dawb tawm. Vim yog cov qauv sib txuas, nws tsis yaj hauv dej; nws o sai sai hauv dej mus txog 4-8 npaug ntawm nws qhov ntim thawj. Cov hmoov muaj cov kua dej zoo.
Daim Ntawv Thov: Nws yog qhov feem ntau siv super disintegrant. Disintegrant rau cov ntsiav tshuaj qhov ncauj, capsules, granules.
2. Carmellose calcium (cross-linked CMCCa):
Cov Khoom: Dawb, hmoov tsis muaj ntxhiab, hygroscopic. 1% kua pH 4.5-6. Yuav luag tsis yaj hauv ethanol thiab ether solvent, tsis yaj hauv dej, tsis yaj hauv dilute hydrochloric acid, me ntsis yaj hauv dilute alkali. lossis off-white hmoov. Vim yog cov qauv sib txuas, nws tsis yaj hauv dej; nws o thaum nws nqus dej.
Daim ntawv thov: ntsiav tshuaj disintegrant, binder, diluent.
3. Methylcellulose (MC):
Qauv: methyl ether ntawm cellulose
Cov Khoom: Dawb mus rau daj dawb hmoov los yog granules. Insoluble nyob rau hauv dej kub, saturated ntsev kua, cawv, ether, acetone, toluene, chloroform; soluble nyob rau hauv glacial acetic acid los yog sib npaug zos sib xyaw ntawm cawv thiab chloroform. Qhov solubility nyob rau hauv dej txias yog txuam nrog rau qib ntawm kev hloov pauv, thiab nws yog feem ntau soluble thaum qib ntawm kev hloov pauv yog 2.
Daim ntawv thov: cov khoom siv khi rau ntsiav tshuaj, cov khoom siv sib xyaw ua ke ntawm cov ntsiav tshuaj lossis kev npaj tso tawm tas mus li, tshuaj pleev lossis gel, tus neeg sawv cev ncua thiab tus neeg sawv cev tuab, txheej ntsiav tshuaj, emulsion stabilizer.
4. Ethyl cellulose (EC):
Qauv: Ethyl ether ntawm cellulose
Cov Khoom: Hmoov dawb los yog daj-dawb thiab granules. Insoluble nyob rau hauv dej, kua gastrointestinal, glycerol thiab propylene glycol. Nws yog yooj yim soluble nyob rau hauv chloroform thiab toluene, thiab tsim ib tug dawb precipitate nyob rau hauv cov ntaub ntawv ntawm ethanol.
Daim Ntawv Thov: Ib qho khoom siv zoo tshaj plaws uas tsis yaj hauv dej, tsim nyog ua cov tshuaj matrix uas rhiab heev rau dej, cov khoom siv uas tsis yaj hauv dej, cov ntawv nplaum ntsiav tshuaj, cov khoom siv zaj duab xis, cov khoom siv microcapsule thiab cov khoom siv txheej txheem tso tawm tas mus li, thiab lwm yam.
5. Hydroxyethyl Cellulose (HEC):
Qauv: Ib feem hydroxyethyl ether ntawm cellulose.
Cov Khoom: Hmoov daj daj los yog dawb mis nyuj. Yaj tag nrho hauv dej txias, dej kub, kua qaub tsis muaj zog, lub hauv paus tsis muaj zog, kua qaub muaj zog, lub hauv paus muaj zog, tsis yaj hauv feem ntau cov kuab tshuaj organic (yaj hauv dimethyl sulfoxide, dimethylformamide), hauv cov kuab tshuaj organic diol polar. Yuav nthuav dav lossis yaj ib nrab.
Daim Ntawv Thov: Cov khoom siv polymer uas yaj tau hauv dej uas tsis yog ionic; cov khoom ua kom tuab rau kev npaj tshuaj qhov muag, otology thiab kev siv rau sab nraud; HEC hauv cov roj nplua nyeem rau qhov muag qhuav, cov iav sib cuag thiab qhov ncauj qhuav; siv rau hauv cov tshuaj pleev ib ce. Ua tus neeg khi, tus neeg sawv cev ua zaj duab xis, tus neeg sawv cev ua kom tuab, tus neeg sawv cev ncua thiab tus neeg sawv cev ruaj khov rau cov tshuaj thiab zaub mov, nws tuaj yeem ntim cov tshuaj me me, yog li cov tshuaj me me tuaj yeem ua lub luag haujlwm qeeb.
6. Hydroxypropyl Cellulose (HPC):
Qauv: Ib feem polyhydroxypropyl ether ntawm cellulose
Cov Khoom: HPC uas muaj ntau yam hloov pauv yog hmoov dawb lossis daj me ntsis. Yaj hauv methanol, ethanol, propylene glycol, isopropanol, dimethyl sulfoxide thiab dimethyl formamide, qhov siab dua viscosity version tsis yaj. Insoluble hauv dej kub, tab sis tuaj yeem o. Thermal gelation: yooj yim soluble hauv dej qis dua 38 ° C, gelatinized los ntawm cua sov, thiab tsim flocculent o ntawm 40-45 ° C, uas tuaj yeem rov qab los ntawm kev txias.
L-HPC cov yam ntxwv zoo tshaj plaws: tsis yaj hauv dej thiab cov kuab tshuaj organic, tab sis o tuaj yeem hauv dej, thiab cov khoom o tuaj yeem nce ntxiv nrog kev nce ntawm cov khoom hloov pauv
Daim Ntawv Thov: HPC uas muaj ntau yam hloov pauv yog siv los ua cov ntawv nplaum rau ntsiav tshuaj, cov neeg sawv cev granulating, cov khoom siv txheej zaj duab xis, thiab kuj tseem siv tau ua cov khoom siv zaj duab xis microencapsulated, cov khoom siv matrix thiab cov khoom siv pabcuam ntawm cov ntsiav tshuaj khaws cia plab, cov khoom siv tuab thiab cov khoom siv tiv thaiv, kuj siv feem ntau hauv cov thaj ua rau transdermal.
L-HPC: Feem ntau siv ua cov tshuaj yaj lossis cov khoom siv rau cov granulation ntub, ua cov ntsiav tshuaj matrix uas tso tawm tas mus li, thiab lwm yam.
7. Hypromellose (HPMC):
Qauv: Ib feem methyl thiab ib feem polyhydroxypropyl ether ntawm cellulose
Cov Khoom: Dawb los yog dawb tawm-dawb fibrous los yog granular hmoov. Nws yog soluble nyob rau hauv dej txias, insoluble nyob rau hauv dej kub, thiab muaj thermal gelation zog. Nws yog soluble nyob rau hauv methanol thiab ethanol cov kua, chlorinated hydrocarbons, acetone, thiab lwm yam. Nws yog solubility nyob rau hauv cov organic solvents yog zoo dua li dej-soluble.
Daim Ntawv Thov: Cov khoom no yog cov kua dej uas tsis muaj viscosity siv ua cov khoom siv txheej zaj duab xis; cov kua organic solvent uas muaj viscosity siab siv ua cov ntawv nplaum ntsiav tshuaj, thiab cov khoom uas muaj viscosity siab siv tau los thaiv cov tshuaj uas yaj tau hauv dej; ua cov tshuaj pleev qhov muag uas ua rau cov kua muag thiab cov kua muag dag, thiab cov neeg sawv cev ntub rau cov iav sib cuag.
8. Hypromellose Phthalate (HPMCP):
Qauv: HPMCP yog phthalic acid ib nrab ester ntawm HPMC.
Cov Khoom: Cov plaub ya ri dawb los yog cov hmoov av. Insoluble hauv dej thiab kua qaub, insoluble hauv hexane, tab sis yooj yim soluble hauv acetone: methanol, acetone: ethanol lossis methanol: chloromethane sib tov.
Daim Ntawv Thov: Ib hom tshiab ntawm cov khoom siv txheej nrog kev ua tau zoo heev, uas tuaj yeem siv ua zaj duab xis txheej kom npog qhov tsw ntawm cov ntsiav tshuaj lossis granules.
9. Hypromellose Acetate Succinate (HPMCAS):
Cov qauv: Sib xyaw acetic thiab succinic esters ntawmHPMC
Cov Khoom: Dawb rau daj dawb hmoov lossis granules. Soluble nyob rau hauv sodium hydroxide thiab sodium carbonate kua, yooj yim soluble nyob rau hauv acetone, methanol lossis ethanol: dej, dichloromethane: ethanol sib tov, insoluble nyob rau hauv dej, ethanol thiab ether.
Daim Ntawv Thov: Ua cov khoom siv ntsiav tshuaj enteric coating, cov khoom siv tso tawm cov khoom siv thiab cov khoom siv txheej zaj duab xis.
10. Agar:
Cov Qauv: Agar yog qhov sib xyaw ua ke ntawm tsawg kawg yog ob lub polysaccharides, kwv yees li 60-80% agarose nruab nrab thiab 20-40% agarose. Agarose yog tsim los ntawm agarobiose repetitive units uas D-galactopyranosose thiab L-galactopyranosose txuas nrog ntawm 1-3 thiab 1-4.
Cov Khoom: Agar yog pob tshab, lub tog raj kheej plaub fab daj daj, daim kab nyias nyias lossis cov nplais lossis cov hmoov. Tsis yaj hauv dej txias, yaj hauv dej npau. Swells 20 zaug hauv dej txias.
Daim Ntawv Thov: Ua tus neeg sawv cev khi, tshuaj pleev puag, suppository puag, emulsifier, stabilizer, suspending agent, kuj yog poultice, capsule, syrup, jelly thiab emulsion.
Lub sijhawm tshaj tawm: Plaub Hlis-26-2024