Hydroxypropylmethylcellulose (HPMC) bụ ihe mejupụtara nke aghọọla ihe eji arụ ọrụ dị mkpa n'ọtụtụ ụlọ ọrụ n'ihi ihe ndị dị na ya nke nwere ọtụtụ ọrụ. A na-ejikarị ya eme ihe dị ka ihe mgbakwunye nri, ihe na-eme ka ọ sie ike na ihe ịchọ mma, na ọbụna ihe mejupụtara ọgwụ n'ọtụtụ ọgwụ. Ihe pụrụ iche nke HPMC bụ àgwà thixotropic ya, nke na-enye ya ohere ịgbanwe viscosity na njirimara mmiri n'okpuru ọnọdụ ụfọdụ. Na mgbakwunye, ma viscosity dị elu na obere viscosity HPMC nwere ihe onwunwe a, na-egosipụta thixotropy ọbụna n'okpuru okpomọkụ gel.
Thixotropy na-eme na HPMC mgbe ihe ngwọta na-aghọ ihe na-eme ka ọ dị mkpụmkpụ ma ọ bụrụ na e tinye nrụgide ma ọ bụ kpalie ya, nke na-eme ka ọ daa na viscosity. A pụkwara ịgbanwe omume a; mgbe ewepụrụ nrụgide ahụ ma hapụ ihe ngwọta ahụ ka ọ zuru ike, viscosity ahụ na-alaghachi nwayọ nwayọ n'ọnọdụ ya dị elu. Ihe pụrụ iche a na-eme ka HPMC bụrụ ihe bara uru n'ọtụtụ ụlọ ọrụ ebe ọ na-enye ohere maka ojiji dị nro na nhazi dị mfe.
Dịka hydrocolloid na-abụghị nke ionic, HPMC na-aza n'ime mmiri iji mepụta gel. Ogo nke ọzịza na gelling na-adabere na ibu molekul na mkpokọta nke polima, pH na okpomọkụ nke ngwọta ahụ. Oke viscosity HPMC na-enwekarị ibu molekul dị elu ma na-emepụta gel viscosity dị elu, ebe obere viscosity HPMC nwere obere ibu molekul ma na-emepụta gel viscosity dị obere. Agbanyeghị, n'agbanyeghị ọdịiche ndị a na arụmọrụ, ụdị HPMC abụọ ahụ na-egosipụta thixotropy n'ihi mgbanwe nhazi nke na-eme na ọkwa molekul.
Omume thixotropic nke HPMC bụ nsonaazụ nke nhazi nke agbụ polymer n'ihi nrụgide shear. Mgbe etinyere nrụgide shear na HPMC, agbụ polymer ahụ na-ahazi n'akụkụ nrụgide etinyere, na-ebute mbibi nke nhazi netwọk akụkụ atọ nke dị adị n'enweghị nrụgide. Nkwụsị nke netwọk ahụ na-ebute mbelata na viscosity ngwọta. Mgbe ewepụrụ nrụgide ahụ, agbụ polymer ahụ na-ahazi n'akụkụ mbụ ha, na-ewughachi netwọk ahụ ma na-eweghachi viscosity.
HPMC na-egosipụtakwa thixotropy n'okpuru okpomọkụ gelling. Okpomọkụ gel bụ okpomọkụ ebe agbụ polymer na-ejikọ iji mepụta netwọk akụkụ atọ, na-emepụta gel. Ọ dabere na mkpokọta, ibu molekul na pH nke ngwọta nke polymer. Gel nke a na-esi na ya apụta nwere viscosity dị elu ma anaghị agbanwe ngwa ngwa n'okpuru nrụgide. Agbanyeghị, n'okpuru okpomọkụ gelation, ngwọta HPMC ka dị mmiri mmiri, mana ọ ka gosipụtara omume thixotropic n'ihi ọnụnọ nke nhazi netwọk nke e guzobere akụkụ. Netwọk nke akụkụ ndị a mepụtara na-agbaji n'okpuru nrụgide, na-ebute mbelata na viscosity. Omume a bara uru n'ọtụtụ ngwa ebe ngwọta kwesịrị ịgba ọsọ ngwa ngwa mgbe a kpaliri ya.
HPMC bụ kemịkalụ dị iche iche nwere ọtụtụ ihe pụrụ iche, otu n'ime ha bụ àgwà thixotropic ya. Ma viscosity dị elu ma viscosity dị ala HPMC nwere ihe onwunwe a, na-egosipụta thixotropy ọbụna n'okpuru okpomọkụ gel. Njirimara a na-eme ka HPMC bụrụ ihe bara uru n'ọtụtụ ụlọ ọrụ ndị chọrọ ngwọta ndị na-ejikwa mmiri dị mfe iji hụ na ejiri ya mee ihe nke ọma. N'agbanyeghị ọdịiche dị n'ihe onwunwe dị n'etiti viscosity dị elu na viscosity dị ala HPMC, omume thixotropic ha na-eme n'ihi nhazi na mmebi nke nhazi netwọk nke e guzobere n'ime akụkụ. N'ihi ihe pụrụ iche ya, ndị nchọpụta na-enyocha ngwa dị iche iche nke HPMC mgbe niile, na-atụ anya ịmepụta ngwaahịa ọhụrụ ma nye ngwọta ka mma maka ndị ahịa gburugburu ụwa.
Oge ozi: Ọgọst-23-2023