I te haere tonu o te ahumahi me te whakapainga o te hangarau, mā te whakaurunga me te whakapai ake i ngā mīhini rehu moata o tāwāhi, kua tino whanake te hangarau rehu me te whakapiri miihini i tōku whenua i ngā tau tata nei. He rerekē te moata rehu miihini i te moata noa, e hiahia ana ki te mahi pupuri wai teitei, te rere tika me te mahi ārai-totoka. I te nuinga o te wā, ka tāpirihia te hydroxypropyl methylcellulose ki te moata, ko te cellulose Ether (HPMC) te mea e whakamahia whānuitia ana. Ko ngā mahi matua o te hydroxypropyl methylcellulose HPMC i roto i te moata ko: te whakamātotoru me te whakakīkī, te whakatikatika i te rheology, me te kaha pupuri wai pai rawa atu. Heoi, kāore e taea te wareware i ngā ngoikoretanga o te HPMC. He pānga hopu-hau te HPMC, ka nui ake ngā hapa o roto, ka tino whakaiti i ngā āhuatanga miihini o te moata. I rangahau a Shandong Chenbang Fine Chemical Co., Ltd. i te awe o te HPMC ki te tere pupuri wai, te mātotoru, te ihirangi hau me ngā āhuatanga miihini o te moata mai i te taha makaro, ā, i ako i te awe o te hydroxypropyl methylcellulose HPMC ki te hanganga L o te moata mai i te taha moroiti.
1. Whakamātautau
1.1 Ngā rauemi mata
Sima: sima P.0 42.5 e wātea ana i te hokohoko, ko tōna kaha piko me te kaha pēhi 28d he 6.9 me te 48.2 MPa; onepu: onepu awa pai o Chengde, 40-100 mata; cellulose ether: i hangaia e Shandong Chenbang Fine Chemical Co., Ltd. Hydroxypropyl methylcellulose ether, paura mā, matotoru ingoa 40, 100, 150, 200 Pa-s; wai: wai puna ma.
1.2 Tikanga whakamātautau
E ai ki te JGJ/T 105-2011 "Ngā Ture Hanga mō te Rehu Ā-Mīhini me te Pāreti", ko te matotoru o te moata he 80-120 mm, ā, ko te tere pupuri wai he nui ake i te 90%. I roto i tēnei whakamātautau, i whakatakotoria te ōwehenga raima-onepu ki te 1:5, i whakahaeretia te matotoru ki te (93+2) mm, ā, i whakaranua te cellulose ether ki waho, ā, ko te nui o te ranunga i ahu mai i te papatipu sima. Ko ngā āhuatanga taketake o te moata pēnei i te mātotoru mākū, te nui o te hau, te pupuri wai, me te matotoru ka whakamatautauria me te aro ki te JGJ 70-2009 "Ngā Tikanga Whakamātautau mō ngā Āhuatanga Taketake o te Moata Hanga", ā, ka whakamatautauria, ka tatauhia hoki te nui o te hau kia rite ki te tikanga mātotoru. Ko ngā whakamātautau whakarite, te kaha piko me te kaha pēhi o ngā tauira i mahia kia rite ki te GB/T 17671-1999 "Ngā Tikanga mō te Whakamātautau i te Kaha o te Onepu Moata Sima (Tikanga ISO)". I inehia te diameter o ngā torongū mā te ine i te mercury porosimetry. Ko te tauira o te mita pūwero konukōrei ko AUTOPORE 9500, ā, ko te whānuitanga ine he 5.5 nm-360 μm. E 4 ngā huinga whakamātautau katoa i mahia. Ko te ōwehenga sima-onepu he 1:5, ko te matotoru o te HPMC he 100 Pa-s, ā, ko te inenga he 0, 0.1%, 0.2%, 0.3% (ko ngā tau ko A, B, C, D ia).
2. Ngā hua me te tātari
2.1 Te pānga o te HPMC ki te tere pupuri wai o te moata sima
Ko te pupuri wai e pā ana ki te kaha o te moata ki te pupuri wai. I roto i te moata rehuhia e te mīhini, mā te tāpiri i te cellulose ether ka taea te pupuri i te wai, te whakaiti i te tere o te toto, me te whakatutuki i ngā whakaritenga o te makuku katoa o ngā rauemi sima. Te pānga o te HPMC ki te pupuri wai o te moata.
I te pikinga ake o te ihirangi HPMC, ka piki haere te tere pupuri wai o te moata. He rite tonu ngā pihi o te hydroxypropyl methylcellulose ether me ngā matotoru o te 100, 150 me te 200 Pa.s. Ina 0.05%-0.15% te ihirangi, ka piki haere te tere pupuri wai, ā, ina 0.15% te ihirangi, ka nui ake te tere pupuri wai i te 93%. Ina neke atu te nui o ngā kirikiri i te 0.20%, ka papatahi te ia o te pikinga o te tere pupuri wai, e tohu ana kei te tata te nui o te HPMC ki te mākū. He rārangi tika te pihi awe o te nui o te HPMC me te matotoru o te 40 Pa.s ki te tere pupuri wai. Ina nui ake te nui i te 0.15%, he iti iho te tere pupuri wai o te moata i ērā o ngā momo HPMC e toru me te nui o te matotoru. Ko te tikanga pupuri wai o te cellulose ether e whakaponohia whānuitia ana ko: ko te rōpū hydroxyl i runga i te ngota cellulose ether me te ngota hāora i runga i te here ether ka hono ki te ngota wai hei hanga i te here hauwai, kia noho ai te wai kore utu hei wai here, ā, ka whai pānga pupuri wai pai; E whakaponohia ana hoki ko te whakawhitiwhiti i waenga i ngā ngota wai me ngā mekameka ngota cellulose ether ka taea e ngā ngota wai te tomo ki roto i ngā mekameka macromolecular cellulose ether, ā, ka pāngia e ngā kaha here kaha, ā, ka whakapai ake i te pupuri wai o te paru sima. Mā te pupuri wai pai ka taea te pupuri i te moata kia ōrite, kāore e ngāwari ki te wehewehe, ā, ka whiwhi i te mahi whakaranu pai, me te whakaiti i te kakahu miihini me te whakanui ake i te roa o te ora o te mīhini rehu moata.
2.2 Te pānga o te hydroxypropyl methylcellulose HPMC ki te mātotoru me te nui o te hau i roto i te moata sima
Ina he 0-0.20% te nui o te HPMC, ka heke tere te mātotoru o te moata me te pikinga ake o te nui o te HPMC, mai i te 2050 kg/m3 ki te 1650kg/m3 pea, he iti iho i te 20% pea; ina neke atu te nui o te HPMC i te 0.20%, ka heke te mātotoru. i te marino. Ki te whakataurite i ngā momo HPMC e 4 me ngā matotoru rerekē, ka teitei ake te matotoru, ka iti ake te mātotoru o te moata; ko ngā ānau matotoru o ngā moata me ngā matotoru whakauru o te 150 me te 200 Pa.s HPMC e taupatupatu ana, e tohu ana i te piki haere tonu o te matotoru o te HPMC, kāore te Mātotoru e heke.
He rerekē te ture whakarerekētanga o te ihirangi hau o te moata ki te whakarerekētanga o te mātotoru o te moata. Ina he 0-0.20% te ihirangi o te hydroxypropyl methylcellulose HPMC, me te pikinga o te ihirangi HPMC, ka tata te pikinga o te ihirangi hau o te moata; ka nui ake te ihirangi o te HPMC. I muri i te 0.20%, kāore e tino rerekē te ihirangi hau, e tohu ana kei te tata te pānga hopu-hau o te moata ki te mākū. He nui ake te pānga hopu-hau o te HPMC me te matotoru o te 150 me te 200 Pa.s i tō te HPMC me te matotoru o te 40 me te 100 Pa.s.
Ko te pānga o te cellulose ether ki te hau ka whakatauhia e tōna hanganga ngota. He rōpū hydrophilic (hydroxyl, ether) me ngā rōpū hydrophobic (methyl, glucose ring) te cellulose ether, ā, he surfactant. , he mahi mata, nō reira he pānga ki te hau. I tetahi taha, ka taea e te hau whakauru te mahi hei peera pōro i roto i te moata, te whakapai ake i te mahi a te moata, te whakanui ake i te rōrahi, me te whakanui ake i te putanga, he mea pai ki te kaihanga. Engari i tetahi atu taha, ka whakanui ake te pānga ki te hau i te ihirangi hau o te moata me te porosity i muri i te whakapakeketanga, ka hua ake te pikinga o ngā pore kino me te whakaiti nui i ngā āhuatanga miihini. Ahakoa he pānga ki te hau te HPMC, kāore e taea te whakakapi i te kaihoko ki te hau. Hei tāpiri, ina whakamahia te HPMC me te kaihoko ki te hau i te wā kotahi, ka kore pea te kaihoko ki te hau e mahi.
2.3 Te pānga o te HPMC ki ngā āhuatanga ā-pūkaha o te moata sima
Ina 0.05% noa iho te nui o te HPMC, ka tino heke te kaha piko o te moata, arā, tata ki te 25% te iti iho i te tauira kau kore HPMC hydroxypropyl methylcellulose, ā, ka taea anake te kaha pēhi ki te 65% o te tauira kau -80%. Ina neke atu te nui o te HPMC i te 0.20%, kāore e kitea te hekenga o te kaha piko me te kaha pēhi o te moata. He iti noa te pānga o te matotoru o te HPMC ki ngā āhuatanga hangarau o te moata. He maha ngā mirumiru hau iti e puta mai ana i te HPMC, ā, ko te pānga hopu-hau ki te moata ka whakanui ake i te porosity o roto me ngā pore kino o te moata, ka hua ake he hekenga nui o te kaha pēhi me te kaha piko. Ko tētahi atu take mō te hekenga o te kaha o te moata ko te pānga pupuri wai o te cellulose ether, e pupuri ana i te wai i roto i te moata kua whakapakeketia, ā, ko te ōwehenga here-wai nui ka arahi ki te hekenga o te kaha o te poraka whakamātautau. Mō te moata hanga miihini, ahakoa ka taea e te cellulose ether te whakanui ake i te tere pupuri wai o te moata me te whakapai ake i tōna kaha mahi, ki te nui rawa te horopeta, ka pā kino ki ngā āhuatanga miihini o te moata, nō reira me paunatia te whanaungatanga i waenganui i te rua.
I te pikinga ake o te ihirangi o te hydroxypropyl methylcellulose HPMC, i whakaatu te ōwehenga takai o te moata i te ia pikinga whānui, he whanaungatanga rārangi te nuinga. Nā te mea ka whakaurua mai e te cellulose ether he maha o ngā mirumiru hau, ka nui ake ngā hapa i roto i te moata, ā, ka heke tere te kaha pēhi o te moata arataki rōhi, ahakoa ka heke anō te kaha piko ki tētahi taumata; engari ka taea e te cellulose ether te whakapai ake i te ngāwari o te moata, he pai ki te kaha piko, ka puhoi ai te tere heke. Ina whakaarohia whānuitia, ko te pānga whakakotahi o ngā mea e rua ka hua ake te pikinga o te ōwehenga takai.
2.4 Te pānga o te HPMC ki te diameter L o te moata
Mai i te pihi tohatoha rahi o ngā pūwero, ngā raraunga tohatoha rahi o ngā pūwero me ngā tawhā tatauranga o ngā tauira AD, ka kitea he nui te awe o te HPMC ki te hanganga pūwero o te moata sima:
(1) Whai muri i te tāpiri i te HPMC, ka nui haere te rahi o ngā pūwero o te moata sima. I te pihi tohatoha rahi o ngā pūwero, ka neke te horahanga o te ahua ki te taha matau, ā, ka nui haere te uara pūwero e rite ana ki te uara tihi. Whai muri i te tāpiri i te HPMC, ka nui ake te whānui waenga o ngā pūwero o te moata sima i tērā o te tauira kau, ā, ka piki ake te whānui waenga o ngā pūwero o te tauira me te horopeta 0.3% mā te 2 ngā whakarea o te rahi ki te whakataurite ki te tauira kau.
(2) Wehea ngā pūwero i roto i te raima kia whā ngā momo, arā, ngā pūwero kino kore (≤20 nm), ngā pūwero iti iho te kino (20-100 nm), ngā pūwero kino (100-200 nm) me ngā pūwero maha kino (≥200 nm). Ka kitea i te Ripanga 1 ka tino heke te maha o ngā pūwero kino kore, ngā pūwero iti iho rānei te kino i muri i te tāpiri i te HPMC, ā, ka piki ake te maha o ngā pūwero kino kore, ngā pūwero kino ake rānei. Ko ngā pūwero kino kore, ngā pūwero iti iho rānei te kino o ngā tauira kāore i konatunatua ki te HPMC he tata ki te 49.4%. I muri i te tāpiri i te HPMC, ka tino heke te maha o ngā pūwero kino kore, ngā pūwero iti iho rānei te kino. Hei tauira, ko te horopeta o te 0.1%, ka heke te maha o ngā pūwero kino kore, ngā pūwero iti iho rānei te kino mā te tata ki te 45%. %, ka piki ake te maha o ngā pūwero kino nui atu i te 10um mā te tata ki te 9 ngā wā.
(3) Kāore te whānui waenga o ngā pore, te whānui toharite o ngā pore, te rōrahi motuhake o ngā pore me te horahanga mata motuhake e whai i tētahi ture whakarerekētanga tino pakari me te pikinga o te ihirangi HPMC hydroxypropyl methylcellulose, e pā ana pea ki te kōwhiringa tauira i roto i te whakamātautau werohanga mercury. e pā ana ki te horahanga nui. Engari i te nuinga o te wā, ko te whānui waenga o ngā pore, te whānui toharite o ngā pore me te rōrahi motuhake o te tauira i konatunatua ki te HPMC ka piki ake ki te tauira kau, i te mea ka heke te horahanga mata motuhake.
Wā tuku: Paenga-whāwhā-03-2023