yazisa
Ii-cellulose ethers zii-polymers ezinyibilikayo emanzini eziphuma kwi-cellulose. Ezi polymers zinezicelo ezininzi kumashishini ahlukeneyo afana nokutya, amayeza, izinto zokuthambisa, kunye nokwakha ngenxa yeempawu zazo ezifana nokuqina, i-gelling, ukwenza ifilimu, kunye ne-emulsifying. Enye yezona mpawu zibalulekileyo zee-cellulose ethers bubushushu bazo be-thermal gelation (Tg), ubushushu apho i-polymer idlula khona utshintsho lwesigaba ukusuka kwi-sol ukuya kwi-gel. Le mpawu ibalulekile ekumiseleni ukusebenza kwee-cellulose ethers kwizicelo ezahlukeneyo. Kweli nqaku, sixoxa ngobushushu be-thermal gelation be-hydroxypropyl methylcellulose (HPMC), enye yee-cellulose ethers ezisetyenziswa kakhulu kushishino.
Ubushushu be-gelation ye-HPMC
I-HPMC yi-semi-synthetic cellulose ether esetyenziswa kakhulu kwiindlela ezahlukeneyo ngenxa yeempawu zayo ezikhethekileyo. I-HPMC iyanyibilika kakhulu emanzini, yenza izisombululo ezicacileyo ezixineneyo kumanqanaba aphantsi. Kumanqanaba aphezulu, i-HPMC yenza iijeli ezinokuthi ziguqulwe xa zifudunyezwa kwaye zipholile. I-heat gelation ye-HPMC yinkqubo enamanyathelo amabini equka ukwakheka kwee-micelles elandelwa kukuhlanganiswa kwee-micelles ukwenza inethiwekhi yejeli (Umfanekiso 1).
Ubushushu be-HPMC ekufudumaleni buxhomekeke kwizinto ezahlukeneyo ezifana neqondo lokutshintshwa (DS), ubunzima be-molecular, uxinzelelo, kunye ne-pH yesisombululo. Ngokubanzi, okukhona i-DS kunye nobunzima be-molecular be-HPMC buphezulu, kokukhona ubushushu be-thermal ekufudumaleni buphezulu. Uxinzelelo lwe-HPMC kwisisombululo luchaphazela ne-Tg, okukhona uxinzelelo luphezulu, kokukhona i-Tg iphezulu. I-pH yesisombululo ichaphazela ne-Tg, kunye nezisombululo ze-asidi ezibangela i-Tg ephantsi.
Ukufakwa kwe-HPMC kubushushu kuyaguquguquka kwaye kunokuchaphazeleka zizinto ezahlukeneyo zangaphandle ezifana namandla okucheba, ubushushu, kunye noxinzelelo lwetyuwa. Ukusika kuyaphula isakhiwo sejeli kwaye kwehlise i-Tg, ngelixa ukunyuka kobushushu kubangela ukuba ijeli inyibilike kwaye yehlise i-Tg. Ukongeza ityuwa kwisisombululo kukwachaphazela i-Tg, kwaye ubukho bee-cations ezifana ne-calcium kunye ne-magnesium kwandisa i-Tg.
Ukusetyenziswa kwe-Tg HPMC ezahlukeneyo
Indlela esebenza ngayo i-HPMC kwi-thermogelling inokwenziwa ngokwezicelo ezahlukeneyo. Ii-HPMC eziphantsi kwe-Tg zisetyenziswa kwizicelo ezifuna i-gelation ekhawulezileyo, njenge-dessert ekhawulezileyo, isosi kunye ne-suphu formulations. I-HPMC ene-Tg ephezulu isetyenziswa kwizicelo ezifuna i-gelation ebambezelekileyo okanye ende, njengokwenziwa kweenkqubo zokuhambisa amayeza, iipilisi zokukhululwa okuqhubekayo, kunye nokubotshwa kwamanxeba.
Kwishishini lokutya, i-HPMC isetyenziswa njengesithambisi, isiqinisi kunye ne-arhente yokugaya. I-HPMC ephantsi isetyenziswa kwiifomyula zedessert ezikhawulezayo ezifuna i-gelation ekhawulezileyo ukuze zinike ubume obufunekayo kunye nokuvakala komlomo. I-HPMC ene-Tg ephezulu isetyenziswa kwiifomyula ezisasazwa ngamafutha aphantsi apho i-gelation ebambezelekileyo okanye ende ifunekayo ukuthintela i-syneresis kunye nokugcina ulwakhiwo olusasazwayo.
Kwishishini lamayeza, i-HPMC isetyenziswa njengesixhobo sokubopha, sokuqhawula kunye nesokukhulula ixesha elide. I-HPMC ene-Tg ephezulu isetyenziswa ekwenzeni iipilisi ezikhutshwa ixesha elide, apho kufuneka i-gelation ebambezelekileyo okanye ende ukuze kukhululwe iyeza ixesha elide. I-HPMC ene-Tg ephantsi isetyenziswa ekwenzeni iipilisi eziqhekekayo ngomlomo, apho kufuneka ukuqhekeka ngokukhawuleza kunye ne-gelation ukuze kunikelwe uvakalelo lomlomo olufunekayo kunye nokulula kokuginya.
ukuququmbela
Ubushushu be-HPMC ekufudumaleni buyimpawu ephambili emisela indlela esebenza ngayo kwiindlela ezahlukeneyo zokusebenza. I-HPMC ingayilungisa i-Tg yayo ngokwezinga lokutshintshwa, ubunzima be-molecular, uxinzelelo kunye nexabiso le-pH yesisombululo ukuze ivumelane nezicelo ezahlukeneyo. I-HPMC ene-Tg ephantsi isetyenziselwa izicelo ezifuna i-gelation ekhawulezayo, ngelixa i-HPMC ene-Tg ephezulu isetyenziselwa izicelo ezifuna i-gelation ebambezelekileyo okanye ende. I-HPMC yi-cellulose ether eguquguqukayo neguquguqukayo enezicelo ezininzi ezinokubakho kwiinkampani ezahlukeneyo.
Ixesha lokuthumela: Agasti-24-2023