Ingabe i-hypromellose acid iyamelana nayo?

I-Hypromellose, eyaziwa nangokuthi i-hydroxypropyl methylcellulose (HPMC), ayimelani ne-asidi ngokwemvelo. Kodwa-ke, ukumelana ne-asidi kwe-hypromellose kungathuthukiswa ngokusebenzisa amasu ahlukahlukene okwakha.

I-Hypromellose iyancibilika emanzini kodwa ayincibiliki kakhulu ezinyibilikisini eziphilayo kanye nasezintweni ezingezona ezimanzi. Ngakho-ke, ezindaweni ezine-asidi, njengesisu, i-hypromellose ingancibilika noma ivuvuke ngezinga elithile, kuye ngezici ezifana nokuhlushwa kwe-asidi, i-pH, kanye nobude besikhathi sokuvezwa.

Ukuze kuthuthukiswe ukumelana ne-asidi ye-hypromellose ekwakhiweni kwemithi, kuvame ukusetshenziswa amasu okugqoka ama-enteric. Ama-enteric coating asetshenziswa kumaphilisi noma kuma-capsule ukuze awavikele endaweni ene-asidi esiswini futhi awavumele ukuthi adlule endaweni engathathi hlangothi yamathumbu amancane ngaphambi kokukhipha izithako ezisebenzayo.

Izembozo ze-enteric zivame ukwenziwa ngama-polymer amelana ne-asidi yesisu, njenge-cellulose acetate phthalate (CAP), i-hydroxypropyl methylcellulose phthalate (HPMCP), noma i-polyvinyl acetate phthalate (PVAP). Lawa ma-polymer akha isithiyo esivikelayo esizungeze ithebhulethi noma i-capsule, esivimbela ukuncibilika noma ukubola ngaphambi kwesikhathi esiswini.

Ngamafuphi, yize i-hypromellose ngokwayo ingamelani ne-asidi, ukumelana kwayo ne-asidi kungathuthukiswa ngokusebenzisa amasu okwakha njengokugqoka kwe-enteric. Lawa masu avame ukusetshenziswa ekwakhiweni kwemithi ukuqinisekisa ukulethwa okuphumelelayo kwezithako ezisebenzayo endaweni ehlosiwe yokusebenza emzimbeni.