Shin sinadarin hypromellose yana da juriya ga cututtuka?

Hypromellose, wanda kuma aka sani da hydroxypropyl methylcellulose (HPMC), ba shi da juriya ga acid. Duk da haka, ana iya ƙara juriyar acid na hypromellose ta hanyar dabarun tsara abubuwa daban-daban.

Hypromellose yana narkewa a cikin ruwa amma ba ya narkewa a cikin sinadarai masu narkewa na halitta da ruwaye marasa polar. Saboda haka, a cikin yanayi mai acidic, kamar ciki, hypromellose na iya narkewa ko kumbura har zuwa wani mataki, ya danganta da abubuwan da suka shafi yawan acid, pH, da tsawon lokacin da aka ɗauka.

Domin inganta juriyar acid na hypromellose a cikin magungunan magani, ana amfani da dabarun rufewa na enteric sau da yawa. Ana shafa murfin enteric a kan allunan ko capsules don kare su daga yanayin acidic na ciki da kuma ba su damar shiga cikin yanayin da ya fi tsaka tsaki na ƙaramin hanji kafin a saki sinadaran da ke aiki.

Ana yin murfin ciki ne da polymers waɗanda ke jure wa acid na ciki, kamar cellulose acetate phthalate (CAP), hydroxypropyl methylcellulose phthalate (HPMCP), ko polyvinyl acetate phthalate (PVAP). Waɗannan polymers suna samar da shinge mai kariya a kusa da kwamfutar hannu ko capsule, wanda ke hana narkewa ko lalacewa da wuri a cikin ciki.

A taƙaice, duk da cewa hypromellose kanta ba ta jure wa acid ba, ana iya ƙara juriyar acid ɗinta ta hanyar dabarun hadawa kamar shafa mai a cikin jiki. Waɗannan dabarun ana amfani da su sosai a cikin magungunan magani don tabbatar da isar da sinadaran aiki yadda ya kamata zuwa wurin da aka nufa a jiki.