Puas yog hypromellose acid tiv taus?

Hypromellose, tseem hu ua hydroxypropyl methylcellulose (HPMC), tsis yog ib yam khoom uas tiv taus kua qaub. Txawm li cas los xij, qhov kev tiv taus kua qaub ntawm hypromellose tuaj yeem txhim kho los ntawm ntau txoj kev tsim cov tshuaj.

Hypromellose yaj tau hauv dej tab sis tsis yaj tau hauv cov organic solvents thiab cov kua uas tsis yog polar. Yog li ntawd, nyob rau hauv cov chaw acidic, xws li lub plab, hypromellose yuav yaj lossis o qee yam, nyob ntawm cov yam xws li qhov concentration ntawm acid, pH, thiab lub sijhawm ntawm kev raug.

Yuav kom txhim kho qhov tsis kam ntawm cov kua qaub ntawm hypromellose hauv cov tshuaj, cov txheej txheem txheej enteric feem ntau siv. Cov txheej txheej enteric raug siv rau cov ntsiav tshuaj lossis tshuaj ntsiav kom tiv thaiv lawv ntawm qhov chaw acidic ntawm lub plab thiab cia lawv hla mus rau qhov chaw nruab nrab ntawm txoj hnyuv me ua ntej tso cov khoom xyaw nquag.

Cov txheej txheej enteric feem ntau yog ua los ntawm cov polymers uas tiv taus cov kua qaub hauv plab, xws li cellulose acetate phthalate (CAP), hydroxypropyl methylcellulose phthalate (HPMCP), lossis polyvinyl acetate phthalate (PVAP). Cov polymers no tsim ib daim thaiv tiv thaiv ib puag ncig lub ntsiav tshuaj lossis tshuaj ntsiav, tiv thaiv kev yaj ua ntej lossis kev puas tsuaj hauv plab.

Hauv kev xaus lus, txawm hais tias hypromellose nws tus kheej tsis tiv taus kua qaub, nws qhov kev tiv taus kua qaub tuaj yeem txhim kho los ntawm cov txheej txheem tsim cov tshuaj xws li enteric coating. Cov txheej txheem no feem ntau siv rau hauv cov tshuaj tsim tshuaj kom ntseeg tau tias cov khoom xyaw nquag xa mus rau qhov chaw ua haujlwm hauv lub cev.