Tiyeni tikambirane za hydroxypropyl methyl celluloseHPMCndi momwe mungayezere kukhuthala kwake. Kukhuthala kumeneku kukutanthauza kukhuthala komwe kumawonekera, komwe ndi chizindikiro chofunikira cha hydroxypropyl methyl cellulose.
Njira Yoyezera Kawirikawiri ndi kuyeza kukhuthala kozungulira, kuyeza kukhuthala kwa capillary ndi kuyeza kukhuthala kogwa. Njira yodziwira hydroxypropyl methyl cellulose inali kumamatira kwa capillary.
Njira yodziwira digiri, pogwiritsa ntchito Uchs viscometer. Kawirikawiri kudziwa yankho ndi 2% yankho lamadzi, fomula ndi iyi: V=Kdt. V ndi kukhuthala mu mpa. s ndipo K ndi viscometer yosasintha.
D ndi kuchuluka kwa zinthu zomwe zimafunika kutentha kofanana ndipo T ndi nthawi yochokera pamwamba mpaka pansi kudzera mu viscometer m'masekondi ochepa. Njira imeneyi ndi yovuta kwambiri ngati pali zinthu zosasungunuka.
Mawu ndi osavuta kuyambitsa zolakwika, n'kovuta kuzindikira mtundu wa hydroxypropyl methyl cellulose. Tsopano imagwiritsidwa ntchito kwambiri poyesa kukhuthala kwa viscometer yozungulira, yomwe imagwiritsidwa ntchito kwambiri ku China.
Fomula ya NDJ-1 viscometer ndi η=Kα. η ndi kukhuthala, komanso mu mpa. s, K ndi coefficient ya viscometer, ndipo α ndi kuwerenga kwa pointer ya viscometer.
Njira yoyesera ya Hydroxypropyl methyl cellulose 2% viscosity:
1, njira iyi ndi yoyenera kudziwa kukhuthala kwa mphamvu kwa madzi osakhala a Newtonian (njira ya polymer, kuyimitsidwa, madzi osakanikirana a emulsion kapena yankho la surfactant, ndi zina zotero).
2. Zida ndi zipangizo
2.1 Choyezera cha Rotary (NdJ-1 ndi NDJ-4 ndizofunikira ndi Chinese Pharmacopoeia)
2.2 Kutentha kosalekeza kwa madzi osambira kulondola kosalekeza kwa kutentha kosalekeza 0.10C
2.3 Mlingo wa zigoli za kutentha ndi 0.20C, zomwe zimatsimikiziridwa nthawi ndi nthawi.
2.4 Ma Viscometer oyezera pafupipafupi omwe amagwiritsa ntchito njira zoyezera kukhazikika kwa pafupipafupi (monga NDJ-1 ndi NDJ-4) ayenera kusungidwa. Kulondola kwa 1%. A
8. Og ya chitsanzocho inayesedwa bwino ndikuyikidwa mu beaker youma komanso yopyapyala ya 400ml. Onjezani pafupifupi 100mL ya madzi otentha a madigiri 80-90 ndikusakaniza kwa mphindi 10 kuti isiyanitsidwe.
Mwazani mofanana, sakanizani ndi kuwonjezera madzi ozizira kufika pa 400mL. Pakadali pano, sakanizani mosalekeza kwa mphindi 30 kuti mupange yankho la 2% (W/W), ndikuliyika mufiriji kuti lizizire mpaka litapanga ayezi woonda pamwamba.
Tulutsani ndi kuyika mu thanki yotenthetsera yosasintha kuti kutentha kwapakati kukhalebe 20 ℃ 0.1 ℃.
3.1 Kukhazikitsa ndi kugwiritsa ntchito chidachi kuyenera kuchitika motsatira malangizo ogwiritsira ntchito chidachi, ndipo chozungulira ndi chozungulira choyenera ziyenera kusankhidwa malinga ndi kuchuluka kwa kukhuthala kwa chinthu choyesedwacho komanso zomwe zili mu pharmacopoeia pansi pa zomwe zili mu chinthucho.
Liwiro lozungulira.
3.2 Sinthani kutentha kwa madzi kokhazikika malinga ndi zomwe zapezeka pansi pa mankhwala aliwonse.
3.3 Chinthu choyeseracho chinayikidwa mu chidebe chomwe chidachitchula, ndipo ngodya ya deflection (a) inayesedwa motsatira lamulo pambuyo pa mphindi 30 za kutentha kosasintha. Zimitsani mota ndikuyiyambitsanso kuti mudziwenso.
Kusiyana pakati pa avareji sikuyenera kupitirira 3%, apo ayi muyeso wachitatu uyenera kupangidwa.
3.4 Werengerani mtengo wapakati wa mayeso awiriwa malinga ndi fomula kuti mupeze kukhuthala kwamphamvu kwa chinthu choyesedwa.
4. Lembani ndi kuwerengera
4.1 Lembani chitsanzo cha viscometer yozungulira, nambala ya rotor ndi liwiro lomwe lagwiritsidwa ntchito, chokhazikika cha viscometer (mtengo wa K), kutentha komwe kwayesedwa, ndi muyeso uliwonse. Mtengo.
Fomula yowerengera ya 4.2
Kukhuthala kwamphamvu (MPa”s)=Ka komwe K ndiye chokhazikika cha viscometer choyesedwa ndi madzi wamba a kukhuthala kodziwika ndipo A ndiye Ngongole ya kutembenuka
Nthawi yotumizira: Epulo-25-2024