HEC neHPMC

Hydroxyethyl Cellulose (HEC)uyeHydroxypropyl Methylcellulose (HPMC)ese ari maviri ma ether e cellulose asinganyunguduke mumvura anobva mu cellulose yechisikigo. Anoshandiswa zvakanyanya mumaindasitiri, mishonga, kutarisira munhu, uye chikafu nekuda kwehunhu hwawo hwakanaka hwekukora, kugadzira firimu, kugadzikana, uye emulsifying. Kunyange zvazvo akafanana pamavambo uye mashandiro, kusiyana kwawo muchimiro chemakemikari kunoita kuti pave nehunhu hwakasiyana hwemuviri uye mashandisirwo.

1. Mavambo uye Maumbirwo eMakemikoro

MaEther eCellulose

HEC neHPMC zvose zvinogadzirwa nekushandisa cellulose yechisikigo inochinja-chinja nemakemikari, inova polymer inoumbwa ne β-D-glucose units yakabatana ne β(1→4) glycosidic bonds. Cellulose pachayo hainyungudike mumvura, asi kuburikidza nekushandisa makemikari, inogona kushandurwa kuita zvinhu zvinonyungudika mumvura.

Hydroxyethyl Cellulose (HEC)

HEC inoumbwa nekubatanidza cellulose ne ethylene oxide, zvichiunza mapoka e hydroxyethyl (-CH2CH2OH) pamwe chete necheni ye polymer. Kuchinja uku kunowedzera kunyungudika kwemvura uye kunovandudza kugona kwe polymer kugadzira mhinduro dzakajeka uye dzakagadzikana. Kutsiva kunoitika zvakanyanya panzvimbo dze hydroxyl (-OH) dzemayuniti e anhydroglucose mucheni ye cellulose.

Hydroxypropyl Methylcellulose (HPMC)

HPMC inogadzirwa nekubatanidza cellulose nemethyl chloride nepropylene oxide, zvichikonzera kuti mapoka ehydroxyl atsiviwe nemapoka emethoxy (-OCH3) uye hydroxypropyl (-CH2CHOHCH3). Chiyero chehuwandu hwemethoxy nehydroxypropyl chinogona kuchinjwa kuti chienderane nemaitiro epolymer.

2. Zvimiro zvemuviri

Kunyunguduka

HEC: Inonyungudika mumvura inopisa neinotonhora, zvichiita mhinduro dzakajeka, dzakasimba. Hainyungudike mune zvakawanda zvinonyungudutsa zvakasikwa.

HPMC: Inonyungudikawo mumvura inotonhora asi inoita gel kana yapiswa. Hainyungudike mumvura inopisa asi inozvimba uye inoumba magel anogadziriswa painodziya, izvo zvinobatsira mukutumira mishonga inoburitswa nemutemo. Mamwe marudzi anogonawo kunyungudika muzvinhu zvinonyungudika zvakaita seethanol kana acetone.

Kusviba

HEC neHPMC zvinogona kugadzirwa mumhando dzakasiyana dze viscosity. Mhinduro dzeHEC dzinowanzo ratidza kujeka kwakanyanya uye hadzinyanyi kukanganiswa nekupisa. Viscosity yeHPMC inowanzo gadzikana zvakanyanya pa pH yakakura (3–11) uye ine maitiro akanaka epseudoplastic (kucheka-kutetepa), izvo zvinobatsira mu coatings uye mishonga.

Kupisa kweGelation

HEC: Hairatidzi kupisa kwemafuta.

HPMC: Inoratidza kupisa kwemafuta. Kana yadziiswa, mushonga wepolymer unoshanduka kuita gel. Izvi zvinoshandiswa mukugadzira chikafu nemishonga.

3. Zvimiro Zvinoshanda

4. Mashandisirwo

Hydroxyethyl Cellulose (HEC)

HEC inoshandiswa zvakanyanya mumabasa anoda kudzora viscosity uye kugadzikana, kunyanya mumasisitimu akavakirwa mumvura.

Pendi neMapendi: Zvinoshandiswa sechinosimbisa uye chinosimbisa ruvara kudzivirira kugadzika kwemavara uye kuvandudza hunhu hwekushandisa.

Kuzvitarisira: Kunowanikwa mushampoos, conditioners, uye lotions nekuda kwehunhu hwayo hwekukora uye kugadzirisa rheology.

Mishonga: Inoshandiswa semushonga wekubatanidza uye wekukora mukugadzirwa kwemishonga.

Kuvaka: Mu simende nedhaka sechinhu chinochengetedza mvura uye chinowedzera kushanda zvakanaka.

Makemikari eOiri: Anoshandiswa mukuchera mvura kuti adzore kusviba uye kudzivirira kurasikirwa nemvura.

Hydroxypropyl Methylcellulose (HPMC)

HPMC inozivikanwa nekushanda kwayo kwakasiyana-siyana muzvinhu zvinobata mvura uye zvinodzora kuburitswa kwemishonga pamwe chete nechinhu chinosunga kana kugadzira firimu.

Mishonga: Inoshandiswa zvakanyanya mumapiritsi anonwiwa (semushonga wekubatanidza, mushonga wekuvhara, kana kuti matrix for release), mhinduro dzemaziso, uye magels emumuviri.

Indasitiri Yezvekudya: Yakatenderwa sechinowedzera chikafu (E464) uye inoshandiswa sechinosimbisa, chinosanganisa, uye chinosimbisa.

Kuvaka: Kunoshandiswa mumadhaka akaoma, zvinonamira mataira, uye maplasta kuti mvura irambe ichichengetwa zvakanaka, irambe ichinamira, uye ishande zvakanaka.

Zvizoro: Zvinoshandiswa mumakirimu, majeli, uye madonhwe emaziso.

Pendi: Dzakafanana neHEC, dzinoshandiswa mukugadzira mishonga inobva mumvura yekudzivirira rheology

5. Misiyano mikuru

6. Kuchengetedzeka uye Kuenderana Kwezvinhu Zvakasiyana-siyana

HEC neHPMC zvose zvinoonekwa sezvisina chepfu uye zvisina chepfu. Hazvinyudzwe mumuviri kana zvikashandiswa pamusoro kana nemuromo muhuwandu hwakajairika. HPMC ine chinzvimbo cheGRAS (Generally Recognised as Safe) uye inoshandiswa zvakanyanya mumaindasitiri emishonga nechikafu nekuda kwekushanda kwayo zvakanaka uye kugamuchirwa kwayo nemutemo.

HEC uye HPMC vanogona kushandisa nzira dzakasiyana-siyana, mapolymer anonyungudika mumvura ane hunhu hwakasiyana hwakagadzirirwa zvinodiwa zvemaindasitiri nemishonga. Kunyange zvazvo ese ari maviri achipa mabasa akanaka ekukora nekudzikamisa, HPMC inoonekwa seyakanaka mumishonga uye chikafu nekuda kwekupisa kwayo uye kubatana kwayo nezvinhu zvipenyu. HEC, kune rumwe rutivi, inonyanya kushandiswa mumvura senge pendi nezvizoro nekuda kwekujeka kwayo uye kugara kwayo zvakanaka mumvura.