HEC a me HPMC

ʻO ka Hydroxyethyl Cellulose (HEC)a meʻO ka Hydroxypropyl Methylcellulose (HPMC)he mau ʻetera cellulose non-ionic, wai-soluble i loaʻa mai ka cellulose kūlohelohe. Hoʻohana nui ʻia lākou i nā ʻoihana ʻoihana, lāʻau lapaʻau, mālama pilikino, a me nā noi meaʻai ma muli o ko lākou mau waiwai mānoanoa maikaʻi loa, hana kiʻiʻoniʻoni, hoʻopaʻa, a me ka emulsifying. ʻOiai ke kaʻana like nei lākou i kekahi mau ʻano like i ke kumu a me ka hana, ʻo ko lākou ʻokoʻa i ke ʻano kemika e hopena i nā waiwai kino a me nā noi like ʻole.

1. Kumu a me ke ʻano kemika

Nā ʻEtera Cellulose

Ua hoʻohui ʻia ʻo HEC a me HPMC ma o ka hoʻololi kemika ʻana i ka cellulose kūlohelohe, he polymer ia i haku ʻia me nā ʻāpana β-D-glucose i hoʻopili ʻia e nā pilina glycosidic β(1→4). ʻAʻole hiki ke hoʻoheheʻe ʻia ka Cellulose i ka wai, akā ma o ka hoʻololi kemika, hiki ke hoʻololi ʻia i mau derivatives wai-soluble.

ʻO ka Hydroxyethyl Cellulose (HEC)

Hoʻokumu ʻia ʻo HEC ma ka hoʻopili ʻana i ka cellulose me ka ethylene oxide, e hoʻokomo ana i nā hui hydroxyethyl (-CH2CH2OH) ma ke kaulahao polymer. Hoʻonui kēia hoʻololi i ka solubility wai a hoʻomaikaʻi i ka hiki o ka polymer ke hana i nā hopena maopopo a paʻa. Hana ʻia ka hoʻololi ʻana ma nā wahi hydroxyl (-OH) o nā ʻāpana anhydroglucose i loko o ke kaulahao cellulose.

ʻO ka Hydroxypropyl Methylcellulose (HPMC)

Hoʻohui ʻia ka HPMC ma ka hoʻohui ʻana i ka cellulose me ka methyl chloride a me ka propylene oxide, e hopena ana i ka hoʻololi ʻana o nā hui hydroxyl me nā hui methoxy (-OCH3) a me hydroxypropyl (-CH2CHOHCH3). Hiki ke hoʻololi ʻia ka lakio o ka methoxy i ka ʻike hydroxypropyl e hoʻopilikino i nā waiwai o ka polymer.

2. Nā Waiwai Kino

Ka hiki ke hoʻoheheʻe ʻia

HEC: Hoʻoheheʻe ʻia i ka wai wela a me ke anuanu, e hana ana i nā hopena moakaka a mānoanoa. ʻAʻole hiki ke hoʻoheheʻe ʻia i ka hapa nui o nā mea hoʻoheheʻe organik.

HPMC: Hoʻoheheʻe ʻia hoʻi i ka wai anuanu akā hana i kahi gel ke hoʻomehana ʻia. ʻAʻole hoʻoheheʻe ʻia i ka wai wela akā pehu a hana i nā gels hoʻohuli ʻia i ka hoʻomehana ʻana, he mea pono ia i ka lawe ʻana i ka lāʻau lapaʻau i hoʻokuʻu ʻia. Hiki ke hoʻoheheʻe ʻia kekahi mau ʻano i nā mea hoʻoheheʻe organik e like me ka ethanol a i ʻole acetone.

Mānoanoa

Hiki ke hana ʻia ʻo HEC a me HPMC i nā ʻano viscosity like ʻole. Hāʻawi pinepine nā hopena HEC i ka mōakāka kiʻekiʻe a ʻaʻole lākou e pili pono i ka mahana. ʻOi aku ka paʻa o ka viscosity HPMC ma kahi ākea pH (3-11) a he ʻano pseudoplastic maikaʻi (shear-thinning), he mea maikaʻi ia i nā uhi a me nā lāʻau lapaʻau.

Hoʻoheheʻe wela

HEC: ʻAʻole hōʻike i ka gelation wela.

HPMC: Hōʻike i ka gelation thermal. Ma hope o ka hoʻomehana ʻana, hele ka hopena polymer i kahi hoʻololi pae, e lilo ana i gel. Hoʻohana ʻia kēia i nā ʻano meaʻai a me nā lāʻau lapaʻau.

3. Nā Waiwai Hana

4. Nā noi

ʻO ka Hydroxyethyl Cellulose (HEC)

Hoʻohana nui ʻia ʻo HEC i nā noi e pono ai ka kaohi a me ka hoʻopaʻa ʻana o ka viscosity, ʻoi aku hoʻi i nā ʻōnaehana wai.

Nā Pena a me nā Uhi: Hoʻohana ʻia ma ke ʻano he mea hoʻomānoanoa a me ka mea hoʻopaʻa e pale ai i ka hoʻomoe ʻana o ka pigment a hoʻomaikaʻi i nā waiwai o ka hoʻopili ʻana.

Mālama Pilikino: Loaʻa i loko o nā shampoos, conditioners, a me nā lotions no kona mau waiwai mānoanoa a me ka hoʻololi ʻana i ka rheology.

Nā lāʻau lapaʻau: Hoʻohana ʻia ma ke ʻano he mea hoʻopaʻa a me ka mea hoʻomānoanoa i nā ʻano hana topical.

Kūkulu ʻana: I loko o ka sima a me ka mortar ma ke ʻano he mea paʻa wai a e hoʻonui i ka hana.

Nā Kemika ʻAila: Hoʻohana ʻia i ka ʻeli ʻana i nā wai no ka kaohi ʻana i ka mānoanoa a me ka pale ʻana i ka pohō wai.

ʻO ka Hydroxypropyl Methylcellulose (HPMC)

He mea kaulana ʻo HPMC no kona versatility i nā ʻōnaehana hoʻouna lāʻau hydrophilic a me ka controlled-release a ma ke ʻano he mea hoʻopaʻa a mea hana kiʻiʻoniʻoni paha.

Nā lāʻau lapaʻau: Hoʻohana nui ʻia i nā papa waha (ma ke ʻano he mea hoʻopaʻa, mea uhi, a i ʻole mea hana matrix no ka hoʻokuʻu mau ʻana), nā hopena ophthalmic, a me nā gels topical.

ʻOihana Meaʻai: Ua ʻāpono ʻia ma ke ʻano he mea hoʻohui meaʻai (E464) a hoʻohana ʻia ma ke ʻano he mea hoʻomānoanoa, emulsifier, a me ka mea hoʻopaʻa.

Hana ʻana: Hoʻohana ʻia i loko o nā mortars hui maloʻo, nā mea hoʻopili tile, a me nā plasters no ka hoʻomaikaʻi ʻana i ka paʻa ʻana o ka wai, ka hoʻopili ʻana, a me ka hana.

Nā mea hoʻonani: Hoʻohana ʻia i loko o nā kirīmi, nā gels, a me nā kulu maka.

Nā Pena: E like me HEC, hoʻohana ʻia i nā ʻano hana wai no ka kaohi ʻana i ka rheology

5. Nā ʻokoʻa koʻikoʻi

6. Palekana a me ka Biocompatibility

Ua manaʻo ʻia ʻo HEC a me HPMC he palekana a ʻaʻohe mea ʻawahia. ʻAʻole lākou e komo i loko o ke kino ke hoʻohana ʻia ma ke ʻano topical a waha paha i nā ʻano maʻamau. Loaʻa iā HPMC ke kūlana GRAS (Generally Recognized as Safe) a hoʻohana nui ʻia i nā ʻoihana lāʻau lapaʻau a me nā meaʻai ma muli o kona biocompatibility maikaʻi loa a me ka ʻae ʻia e nā lula.

HEC a me HPMC he mau mea maʻalahi, nā polymers wai-hoʻoheheʻe ʻia me nā waiwai ʻokoʻa i hana ʻia no nā pono ʻoihana a me nā lāʻau lapaʻau. ʻOiai ʻo nā mea ʻelua e hāʻawi i nā hana mānoanoa a me ka hoʻopaʻa ʻana maikaʻi loa, kū ka HPMC i nā noi lāʻau lapaʻau a me ka meaʻai ma muli o kona gelation thermal a me ka biocompatibility. ʻO HEC, ma ka ʻaoʻao ʻē aʻe, ʻoi aku ka maʻamau i nā noi wai e like me nā pena a me nā mea hoʻonani ma muli o kona maopopo a me ke kūlike i nā ʻōnaehana wai.