Ka anyị kwuo maka hydroxypropyl methyl celluloseHPMCna otu esi atụ nha nha ya. Ọdịdị nha anya ebe a na-ezo aka na ọdịdị anya doro anya, nke bụ ntụaka dị mkpa maka hydroxypropyl methyl cellulose.
Ọkọlọtọ. Ụzọ ndị a na-ejikarị atụ ihe bụ nha viscosity ntụgharị, nha viscosity capillary na nha viscosity ọdịda. Ụzọ e si ekpebi hydroxypropyl methyl cellulose bụ njikọta capillary.
Ụzọ e si ekpebi ogo, site na iji Uchs viscometer. Ọtụtụ mgbe, mkpebi nke ngwọta ahụ bụ 2% mmiri mmiri, usoro ahụ bụ: V = Kdt. V bụ viscosity dị na mpa. s na K bụ viscosometer na-agbanwe agbanwe.
D bụ njupụta na okpomọkụ na-agbanwe agbanwe, T bụkwa oge site n'elu ruo ala site na viscometer n'ime sekọnd. Ụzọ a na-esi arụ ọrụ na-esiri ike karị, ma ọ bụrụ na enwere ihe na-anaghị agbaze.
Okwu dị mfe ịkpata mmejọ, ọ na-esiri ike ịchọpụta ụdị hydroxypropyl methyl cellulose. Ugbu a, a na-ejikarị ya atụ nha nke rotary viscometer, nke a na-ejikarị eme ihe na China.
Usoro nke viscometer NDJ-1 bụ η=Kα. η bụ viscosity, nakwa na mpa. s, K bụ coefficient nke viscometer, na α bụ ọgụgụ nke ihe ntụaka viscometer.
Usoro nnwale viscosity 2% nke hydroxypropyl methyl cellulose:
1, usoro a dabara adaba maka ikpebi viscosity dị ike nke mmiri na-abụghị Newtonian (mgwọta polymer, nkwusioru, mmiri mgbasa emulsion ma ọ bụ ngwọta surfactant, wdg).
2. Ngwa na ngwa ọrụ
2.1 Rotary viscometer (Ndị China Pharmacopoeia chọrọ NdJ-1 na NDJ-4)
2.2 Okpomọkụ na-adịgide adịgide nke mmiri ịsa ahụ na-adịgide adịgide nke ọma 0.10C
2.3 Ogo akara okpomọkụ bụ 0.20C, nke a na-enyocha mgbe niile.
2.4 A ga-echekwa ihe nlele ugboro ugboro nke na-eji usoro nkwụsi ike ugboro ugboro (dịka NDJ-1 na NDJ-4). Izi ezi nke 1%. A
8. A tụbara ihe nlele 0g nke ọma ma tinye ya n'ime beaker kpọrọ nkụ nke dị mita 400 n'ogologo. Tinye ihe dị ka 100mL nke mmiri ọkụ nke ogo 80-90 ma gwakọta ya ruo nkeji iri iji kewaa ya.
Gbasaa ya otu otu, gwakọta ya ma tinye mmiri oyi na 400mL. Ka ọ dịgodị, na-agwakọta ya mgbe niile ruo nkeji iri atọ iji mee ihe ngwọta 2% (W/W), ma tinye ya n'ime friji maka ịsa ahụ ice ka ọ jụọ oyi ruo mgbe ọ ga-adị obere ice n'elu ya.
Wepụta ma tinye ya n'ime tankị okpomọkụ na-agbanwe agbanwe iji mee ka okpomọkụ etiti dị na 20 ℃ 0.1 ℃.
3.1 A ga-arụ ọrụ na ntinye nke ngwa ahụ dịka ntuziaka ọrụ nke ngwa ahụ si dị, a ga-ahọrọkwa rotor na rotor kwesịrị ekwesị dịka oke viscosity nke ngwaahịa a nwalere na ndokwa nke pharmacopoeia n'okpuru ederede nke ngwaahịa ahụ.
Ọsọ ntụgharị.
3.2 Gbanwee okpomọkụ mmiri na-agbanwe agbanwe dịka mkpebi dị n'okpuru ihe ọgwụ ọ bụla si dị.
3.3 E tinyere ngwaahịa nnwale ahụ n'ime akpa nke ngwaọrụ ahụ kwuru, a tụkwara Angle nke na-agbanwe agbanwe (a) dịka iwu si dị mgbe nkeji iri atọ nke okpomọkụ na-adịgide adịgide gasịrị. Gbanyụọ moto ahụ ma malitegharịa ya ọzọ maka mkpebi ọzọ.
Ihe dị iche n'etiti uru nkezi ekwesịghị ịgafe pasentị atọ, ma ọ bụghị ya, a ga-eme nha nke atọ.
3.4 Gbakọọ uru nkezi nke ule abụọ ahụ dịka usoro si dị iji nweta viscosity nke ngwaahịa a nwalere.
4. Dekọọ ma gbakọọ
4.1 Dekọọ ụdị viscometer rotary, ọnụọgụ rotor na ọsọ ejiri, viscometer constant (uru K), okpomọkụ a tụrụ, na nha ọ bụla. Uru.
Usoro ngụkọ nke 4.2
Viskọs dị ike (MPa”s) = Ka ebe K bụ ihe na-agbanwe agbanwe viskọmta nke a tụrụ site na mmiri mmiri nkịtị nke viskọs a maara nke ọma na A bụ akụkụ ntụgharị
Oge ozi: Eprel-25-2024